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学科主题临床医学
Quantitative chimerism: an independent acute leukemia prognosis indicator following allogeneic hematopoietic SCT
Qin, X-Y1,2; Li, G-X1,2; Qin, Y-Z1,2; Wang, Y.1,2; Wang, F-R1,2; Liu, D-H1,2; Xu, L-P1,2; Chen, H.1,2; Han, W.1,2; Wang, J-Z1,2; Zhang, X-H1,2; Li, J-L1,2; Li, L-D1,2; Liu, K-Y1,2; Huang, X-J1,2,3
刊名BONE MARROW TRANSPLANTATION
2014-10-01
DOI10.1038/bmt.2014.158
49期:10页:1269-1277
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; INCREASING MIXED CHIMERISM ; POLYMERASE-CHAIN-REACTION ; ACUTE MYELOID-LEUKEMIA ; SINGLE NUCLEOTIDE POLYMORPHISMS ; COLONY-STIMULATING FACTOR ; GRAFT-VERSUS-LEUKEMIA ; MINIMAL RESIDUAL DISEASE
英文摘要

This study evaluates the prognostic significance of quantitative chimerism to monitor minimal residual disease and predict relapse in acute leukemia (AL) patients following allogeneic hematopoietic SCT (HSCT). The quantitative chimerism levels of 129 AL patients were measured using RQ-PCR based on 29 sequence polymorphisms. Receiver-operating characteristic curve indicated that the optimal cutoff point to predict an inevitable relapse was 1.0%, which results in 100.0% sensitivity and 79.6% specificity. The relapse rate of patients with chimerism > 1.0% at 2 years was 55.0%, whereas that for patients with chimerism < 1.0% was 0%(P = 0.000). Quantitative chimerism > 1.00% indicated a higher probability of relapse. Cox multivariate analysis indicated that quantitative chimerism 41.00% was associated with lower disease-free survival (hazard ratio (HR) = 10.825; 95% confidence interval (CI) = 4.704-24.912, P = 0.000) and lower OS (HR = 8.681; 95% CI = 3.728-20.212, P = 0.000). Patients (24/47 with quantitative chimerism 41.00%) who received preemptive modified DLI immunotherapy had significantly lower relapse rate (37.5%) than those (n=9) who did not (100%; P = 0.001). Thus, quantitative chimerism is an independent prognostic factor that predicts clinical outcomes after HSCT and provides a guide for suitable interventions.

语种英语
WOS记录号WOS:000343660300005
项目编号81230013 ; 81170483 ; Z121107002612035 ; 2011-4022-08
资助机构Key Program of National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Scientific Research Foundation for Capital Medicine Development
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62535
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Qin, X-Y,Li, G-X,Qin, Y-Z,et al. Quantitative chimerism: an independent acute leukemia prognosis indicator following allogeneic hematopoietic SCT[J]. BONE MARROW TRANSPLANTATION,2014,49(10):1269-1277.
APA Qin, X-Y.,Li, G-X.,Qin, Y-Z.,Wang, Y..,Wang, F-R.,...&Huang, X-J.(2014).Quantitative chimerism: an independent acute leukemia prognosis indicator following allogeneic hematopoietic SCT.BONE MARROW TRANSPLANTATION,49(10),1269-1277.
MLA Qin, X-Y,et al."Quantitative chimerism: an independent acute leukemia prognosis indicator following allogeneic hematopoietic SCT".BONE MARROW TRANSPLANTATION 49.10(2014):1269-1277.
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