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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Quantitative chimerism: an independent acute leukemia prognosis indicator following allogeneic hematopoietic SCT
作者: Qin, X-Y1,2; Li, G-X1,2; Qin, Y-Z1,2; Wang, Y.1,2; Wang, F-R1,2; Liu, D-H1,2; Xu, L-P1,2; Chen, H.1,2; Han, W.1,2; Wang, J-Z1,2; Zhang, X-H1,2; Li, J-L1,2; Li, L-D1,2; Liu, K-Y1,2; Huang, X-J1,2,3
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2014-10-01
DOI: 10.1038/bmt.2014.158
卷: 49, 期:10, 页:1269-1277
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; INCREASING MIXED CHIMERISM ; POLYMERASE-CHAIN-REACTION ; ACUTE MYELOID-LEUKEMIA ; SINGLE NUCLEOTIDE POLYMORPHISMS ; COLONY-STIMULATING FACTOR ; GRAFT-VERSUS-LEUKEMIA ; MINIMAL RESIDUAL DISEASE
英文摘要:

This study evaluates the prognostic significance of quantitative chimerism to monitor minimal residual disease and predict relapse in acute leukemia (AL) patients following allogeneic hematopoietic SCT (HSCT). The quantitative chimerism levels of 129 AL patients were measured using RQ-PCR based on 29 sequence polymorphisms. Receiver-operating characteristic curve indicated that the optimal cutoff point to predict an inevitable relapse was 1.0%, which results in 100.0% sensitivity and 79.6% specificity. The relapse rate of patients with chimerism > 1.0% at 2 years was 55.0%, whereas that for patients with chimerism < 1.0% was 0%(P = 0.000). Quantitative chimerism > 1.00% indicated a higher probability of relapse. Cox multivariate analysis indicated that quantitative chimerism 41.00% was associated with lower disease-free survival (hazard ratio (HR) = 10.825; 95% confidence interval (CI) = 4.704-24.912, P = 0.000) and lower OS (HR = 8.681; 95% CI = 3.728-20.212, P = 0.000). Patients (24/47 with quantitative chimerism 41.00%) who received preemptive modified DLI immunotherapy had significantly lower relapse rate (37.5%) than those (n=9) who did not (100%; P = 0.001). Thus, quantitative chimerism is an independent prognostic factor that predicts clinical outcomes after HSCT and provides a guide for suitable interventions.

语种: 英语
所属项目编号: 81230013 ; 81170483 ; Z121107002612035 ; 2011-4022-08
项目资助者: Key Program of National Natural Science Foundation of China ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Scientific Research Foundation for Capital Medicine Development
WOS记录号: WOS:000343660300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62535
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

Recommended Citation:
Qin, X-Y,Li, G-X,Qin, Y-Z,et al. Quantitative chimerism: an independent acute leukemia prognosis indicator following allogeneic hematopoietic SCT[J]. BONE MARROW TRANSPLANTATION,2014,49(10):1269-1277.
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