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学科主题: 临床医学
题名:
Synergistic effect of smoking with genetic variants in the AMPK alpha 1 gene on the risk of coronary artery disease in type 2 diabetes
作者: Ma, Xiaowei; Zhang, Jianwei; Deng, Ruifen; Ding, Shan; Gu, Nan; Guo, Xiaohui
关键词: AMP-activated protein kinase subunit 1 gene ; single nucleotide polymorphisms ; coronary artery disease ; type 2 diabetes mellitus
刊名: DIABETES-METABOLISM RESEARCH AND REVIEWS
发表日期: 2014-09-01
DOI: 10.1002/dmrr.2520
卷: 30, 期:6, 页:483-488
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: ACTIVATED PROTEIN-KINASE
英文摘要:

BackgroundIncreasing evidence suggests that adenosine monophosphate-activated protein kinase (AMPK) plays a critical physiological role in the cardiovascular system. The objective of this study was to assess the possible correlation between the genetic variability of the AMPK1 (PRKAA1) gene and the risk of cardiovascular disease, as well as the interactive effects of the genetic variations and environmental factors, on the risk in Chinese patients with type 2 diabetes.

MethodsFive haplotype-tagging single nucleotide polymorphisms (SNPs) at the AMPK1 locus and 404 unrelated Chinese Han subjects with type 2 diabetes were studied; 260 individuals with coronary artery disease and 144 non-coronary artery disease controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism assay.

ResultsMinor allele C at rs3805489 was protective from coronary artery disease in type 2 diabetic subjects compared with allele A (OR 0.67, 95% CI 0.48-0.92, p=0.015). There was no significant correlation between the genotypes at five SNPs and the risk of coronary artery disease. In addition, a significant interaction was identified between smoking status and rs3805489 (p=0.018 for interaction). The smokers with genotype AA at the SNP had a three-fold higher risk of coronary artery disease compared with non-smokers with genotypes AC or CC (OR 3.02, 95% CI 1.39-6.57, p=0.005, after adjustment for other known coronary artery disease risk factors).

ConclusionsThe genetic variability at the AMPK1 locus has synergetic effects with smoking to increase the risk of coronary artery disease in the Chinese Han population with type 2 diabetes. Copyright (c) 2014 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 2006CB503903-2006CB503908
项目资助者: National 973 Project
WOS记录号: WOS:000341718000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62541
Appears in Collections:北京大学第一临床医学院_内分泌内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China

Recommended Citation:
Ma, Xiaowei,Zhang, Jianwei,Deng, Ruifen,et al. Synergistic effect of smoking with genetic variants in the AMPK alpha 1 gene on the risk of coronary artery disease in type 2 diabetes[J]. DIABETES-METABOLISM RESEARCH AND REVIEWS,2014,30(6):483-488.
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