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Synergistic effect of smoking with genetic variants in the AMPK alpha 1 gene on the risk of coronary artery disease in type 2 diabetes
Ma, Xiaowei; Zhang, Jianwei; Deng, Ruifen; Ding, Shan; Gu, Nan; Guo, Xiaohui
关键词AMP-activated protein kinase subunit 1 gene single nucleotide polymorphisms coronary artery disease type 2 diabetes mellitus
刊名DIABETES-METABOLISM RESEARCH AND REVIEWS
2014-09-01
DOI10.1002/dmrr.2520
30期:6页:483-488
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]ACTIVATED PROTEIN-KINASE
英文摘要

BackgroundIncreasing evidence suggests that adenosine monophosphate-activated protein kinase (AMPK) plays a critical physiological role in the cardiovascular system. The objective of this study was to assess the possible correlation between the genetic variability of the AMPK1 (PRKAA1) gene and the risk of cardiovascular disease, as well as the interactive effects of the genetic variations and environmental factors, on the risk in Chinese patients with type 2 diabetes.

MethodsFive haplotype-tagging single nucleotide polymorphisms (SNPs) at the AMPK1 locus and 404 unrelated Chinese Han subjects with type 2 diabetes were studied; 260 individuals with coronary artery disease and 144 non-coronary artery disease controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism assay.

ResultsMinor allele C at rs3805489 was protective from coronary artery disease in type 2 diabetic subjects compared with allele A (OR 0.67, 95% CI 0.48-0.92, p=0.015). There was no significant correlation between the genotypes at five SNPs and the risk of coronary artery disease. In addition, a significant interaction was identified between smoking status and rs3805489 (p=0.018 for interaction). The smokers with genotype AA at the SNP had a three-fold higher risk of coronary artery disease compared with non-smokers with genotypes AC or CC (OR 3.02, 95% CI 1.39-6.57, p=0.005, after adjustment for other known coronary artery disease risk factors).

ConclusionsThe genetic variability at the AMPK1 locus has synergetic effects with smoking to increase the risk of coronary artery disease in the Chinese Han population with type 2 diabetes. Copyright (c) 2014 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000341718000006
项目编号2006CB503903-2006CB503908
资助机构National 973 Project
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62541
专题北京大学第一临床医学院_内分泌内科
作者单位Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Ma, Xiaowei,Zhang, Jianwei,Deng, Ruifen,et al. Synergistic effect of smoking with genetic variants in the AMPK alpha 1 gene on the risk of coronary artery disease in type 2 diabetes[J]. DIABETES-METABOLISM RESEARCH AND REVIEWS,2014,30(6):483-488.
APA Ma, Xiaowei,Zhang, Jianwei,Deng, Ruifen,Ding, Shan,Gu, Nan,&Guo, Xiaohui.(2014).Synergistic effect of smoking with genetic variants in the AMPK alpha 1 gene on the risk of coronary artery disease in type 2 diabetes.DIABETES-METABOLISM RESEARCH AND REVIEWS,30(6),483-488.
MLA Ma, Xiaowei,et al."Synergistic effect of smoking with genetic variants in the AMPK alpha 1 gene on the risk of coronary artery disease in type 2 diabetes".DIABETES-METABOLISM RESEARCH AND REVIEWS 30.6(2014):483-488.
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