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学科主题: 基础医学
题名:
Treadmill exercise promotes interleukin 15 expression in skeletal muscle and interleukin 15 receptor alpha expression in adipose tissue of high-fat diet rats
作者: Yang, Hongtao1; Chang, Jinrui2; Chen, Wenjia3; Zhao, Lei2; Qu, Bo1; Tang, Chaoshu2; Qi, Yongfen2; Zhang, Jing1
关键词: Interleukin-15 ; Treadmill running ; Obesity ; Skeletal muscle
刊名: ENDOCRINE
发表日期: 2013-06-01
DOI: 10.1007/s12020-012-9809-6
卷: 43, 期:3, 页:579-585
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: PRIMARY PIG ADIPOCYTES ; IL-2 RECEPTOR ; BETA-CHAIN ; OBESITY ; MYOKINES ; CELLS ; ASSOCIATION ; RESISTANCE ; COMPLEXES ; PROTEIN
英文摘要:

Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent treadmill running at 26 m/min (60 min each, 5 days/week for 8 weeks). High-fat diet induced obesity, with increased body weight, body fat, and lipid profile. The level of IL-15 immunoreactivity (IL-15-ir) in plasma and gastrocnemius muscle was lower in obese than control rats, and the mRNA level of IL-15 in gastrocnemius muscle was markedly decreased. The mRNA and protein levels of IL-15R in adipose tissue were markedly lower in obese rats. Compared with sedentary obese rats, treadmill running showed decreased body weight and elevated mRNA expression of IL-15 in muscle and elevated IL-15-ir level in plasma and muscle. The mRNA and protein level of IL-15R were increased in adipose tissue in treadmill running obese rats. Our results showed that exercise training improve obesity and reversed the downregulation of the IL-15 in muscle and IL-15R in adipose tissue induced by high-fat diet.

语种: 英语
所属项目编号: 81270921
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000318294400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62548
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
3.Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China

Recommended Citation:
Yang, Hongtao,Chang, Jinrui,Chen, Wenjia,et al. Treadmill exercise promotes interleukin 15 expression in skeletal muscle and interleukin 15 receptor alpha expression in adipose tissue of high-fat diet rats[J]. ENDOCRINE,2013,43(3):579-585.
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