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Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata
Zhang, Xing1,4; Ye, Min1; Dong, Yin-hui2; Hu, Hong-bo2; Tao, Si-jia3; Yin, Jun4; Guo, De-an1,3
关键词Saussurea involucrata Asterates Biotransformation Bufadienolides Cell suspension culture Cytotoxicity
刊名PHYTOCHEMISTRY
2011-10-01
DOI10.1016/j.phytochem.2011.05.004
72期:14-15页:1779-1785
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Plant Sciences
资助者Peking University Health Science Center ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Peking University Health Science Center ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education of China
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]CYTOTOXIC BUFADIENOLIDES ; MICROBIAL HYDROXYLATION ; CATHARANTHUS-ROSEUS ; CINOBUFAGIN ; BUFALIN ; 12-BETA-HYDROXYLATION ; APOPTOSIS
英文摘要

The biotransformation of three bioactive bufadienolides, namely, bufotalin (1), telocinobufagin (2), and gamabufotalin (3) by cell suspension cultures of Saussurea involucrata yielded 11 products. Bufotalin yielded 3-epi-bufotalin (1a), 3-epi-desacetylbufotalin (1b), 3-epi-bufotalin 3-O-beta-D-glucoside (1c), 1 beta-hydroxybufotalin (1d), and 5 beta-hydroxybufotalin (1e); telocinobufagin yielded 3-dehydroscillarenin (2a), 3-dehydrobufalin (2b), and 3-epi-telocinobufagin (2c); and gamabufotalin yielded 3-epi-gamabufotalin (3a), 3-dehydrogamabufotalin (3b), and 3-dehydro-Delta(1)-gamabufotalin (3c), respectively. Among these 11 products, 1a, 1b, 1c, 1d, 3a and 3c are previously unreported. The structures of these metabolites were elucidated based on NMR spectroscopic analyses and mass spectrometry. Most metabolites showed significant cytotoxic activities against human hepatoma (HepG2) and breast cancer (MCF-7) cell lines. In addition, the time course for the biotransformation of 3 was investigated. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号985-2-119-121 ; 2009802
资助者Peking University Health Science Center ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Peking University Health Science Center ; Beijing Nova Program ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号WOS:000294973300009
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62550
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
3.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
4.Shenyang Pharmaceut Univ, Dept Pharmacognosy, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xing,Ye, Min,Dong, Yin-hui,et al. Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata[J]. PHYTOCHEMISTRY,2011,72(14-15):1779-1785.
APA Zhang, Xing.,Ye, Min.,Dong, Yin-hui.,Hu, Hong-bo.,Tao, Si-jia.,...&Guo, De-an.(2011).Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata.PHYTOCHEMISTRY,72(14-15),1779-1785.
MLA Zhang, Xing,et al."Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata".PHYTOCHEMISTRY 72.14-15(2011):1779-1785.
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