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学科主题: 临床医学
题名:
Clinicopathologic Features and Outcomes in Endocapillary Proliferative IgA Nephropathy
作者: Liu, Li-jun; Li, Guang-tao; Zhou, Yang; Lv, Ji-cheng; Zhang, Hong
关键词: Endocapillary proliferation ; Glomerular sclerosis ; IgA glomerulonephritis ; Renal prognosis
刊名: NEPHRON CLINICAL PRACTICE
发表日期: 2010
DOI: 10.1159/000312880
卷: 115, 期:2, 页:C161-C167
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: IMMUNOGLOBULIN-A NEPHROPATHY ; NATURAL-HISTORY ; MESANGIAL NEPHROPATHY ; PROGNOSTIC INDICATORS ; GLOMERULONEPHRITIS ; CLASSIFICATION ; CHILDREN ; LESIONS ; CHINA
英文摘要:

Objective: Clinical manifestations and histological lesions of IgA nephropathy are variable and correlate with the renal outcome of the patient. The aim of the present study is to clarify the clinicopathological features and the prognosis of patients with IgA nephropathy presenting with dominant diffuse endocapillary proliferative lesions. Methods: The morphological and clinical features of 126 patients with and without diffuse endocapillary proliferation were compared. 29 out of 126 are IgA nephritis patients with diffuse endocapillary proliferation. The others are patients without diffuse endocapillary proliferation. The prognosis of the patients in the 2 groups was analyzed and the effects of diffuse endocapillary proliferation on renal progression in patients with different renal function were also analyzed. Results: Patients with diffuse endocapillary proliferation show significantly higher proteinuria (p < 0.0001) and crescent percent (p < 0.05). There is no significant difference of renal survival in patients with or without diffuse endocapillary proliferation. Further analysis indicated that patients with diffuse endocapillary proliferation had better renal survival than those without it (log rank, p = 0.0561) if their renal function was normal, whereas renal survival of patients with diffuse endocapillary proliferation was worse than of those without it if their renal function was abnormal (log rank, p = 0.0763). Conclusion: IgA nephropathy with diffuse endocapillary proliferation shows a better prognosis in the patients with normal renal function, but it is a relative risk factor for end-stage renal disease in patients with abnormal renal function. Copyright (C) 2010 S. Karger AG, Basel

语种: 英语
WOS记录号: WOS:000278659100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62555
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Peking Univ Hosp 1, Key Lab Renal Dis, Renal Div,Inst Nephrol,Minist Hlth China, Beijing 97034, Peoples R China

Recommended Citation:
Liu, Li-jun,Li, Guang-tao,Zhou, Yang,et al. Clinicopathologic Features and Outcomes in Endocapillary Proliferative IgA Nephropathy[J]. NEPHRON CLINICAL PRACTICE,2010,115(2):C161-C167.
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