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学科主题临床医学
Clinicopathologic Features and Outcomes in Endocapillary Proliferative IgA Nephropathy
Liu, Li-jun; Li, Guang-tao; Zhou, Yang; Lv, Ji-cheng; Zhang, Hong
关键词Endocapillary proliferation Glomerular sclerosis IgA glomerulonephritis Renal prognosis
刊名NEPHRON CLINICAL PRACTICE
2010
DOI10.1159/000312880
115期:2页:C161-C167
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]IMMUNOGLOBULIN-A NEPHROPATHY ; NATURAL-HISTORY ; MESANGIAL NEPHROPATHY ; PROGNOSTIC INDICATORS ; GLOMERULONEPHRITIS ; CLASSIFICATION ; CHILDREN ; LESIONS ; CHINA
英文摘要

Objective: Clinical manifestations and histological lesions of IgA nephropathy are variable and correlate with the renal outcome of the patient. The aim of the present study is to clarify the clinicopathological features and the prognosis of patients with IgA nephropathy presenting with dominant diffuse endocapillary proliferative lesions. Methods: The morphological and clinical features of 126 patients with and without diffuse endocapillary proliferation were compared. 29 out of 126 are IgA nephritis patients with diffuse endocapillary proliferation. The others are patients without diffuse endocapillary proliferation. The prognosis of the patients in the 2 groups was analyzed and the effects of diffuse endocapillary proliferation on renal progression in patients with different renal function were also analyzed. Results: Patients with diffuse endocapillary proliferation show significantly higher proteinuria (p < 0.0001) and crescent percent (p < 0.05). There is no significant difference of renal survival in patients with or without diffuse endocapillary proliferation. Further analysis indicated that patients with diffuse endocapillary proliferation had better renal survival than those without it (log rank, p = 0.0561) if their renal function was normal, whereas renal survival of patients with diffuse endocapillary proliferation was worse than of those without it if their renal function was abnormal (log rank, p = 0.0763). Conclusion: IgA nephropathy with diffuse endocapillary proliferation shows a better prognosis in the patients with normal renal function, but it is a relative risk factor for end-stage renal disease in patients with abnormal renal function. Copyright (C) 2010 S. Karger AG, Basel

语种英语
WOS记录号WOS:000278659100011
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62555
专题北京大学第一临床医学院_肾脏内科
北京大学口腔医学院_第一门诊部
作者单位Peking Univ, Peking Univ Hosp 1, Key Lab Renal Dis, Renal Div,Inst Nephrol,Minist Hlth China, Beijing 97034, Peoples R China
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Liu, Li-jun,Li, Guang-tao,Zhou, Yang,et al. Clinicopathologic Features and Outcomes in Endocapillary Proliferative IgA Nephropathy[J]. NEPHRON CLINICAL PRACTICE,2010,115(2):C161-C167.
APA Liu, Li-jun,Li, Guang-tao,Zhou, Yang,Lv, Ji-cheng,&Zhang, Hong.(2010).Clinicopathologic Features and Outcomes in Endocapillary Proliferative IgA Nephropathy.NEPHRON CLINICAL PRACTICE,115(2),C161-C167.
MLA Liu, Li-jun,et al."Clinicopathologic Features and Outcomes in Endocapillary Proliferative IgA Nephropathy".NEPHRON CLINICAL PRACTICE 115.2(2010):C161-C167.
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