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学科主题: 临床医学
题名:
Parsimonious Model for Blood Glucose Level Monitoring in Type 2 Diabetes patients
作者: Zhao Fang1; Ma Yan Fen1; Wen Jing Xiao2; Du Yan Fang3; Li Chun Lin4; Li Guang Wei1
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2014-07-01
DOI: 10.3967/bes2014.086
卷: 27, 期:7, 页:559-563
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: RANDOMIZED-TRIAL ; PARALLEL-GROUP ; MANAGEMENT ; MELLITUS ; INSULIN
英文摘要:

To establish the parsimonious model for blood glucose monitoring in patients with type 2 diabetes receiving oral hypoglycemic agent treatment. One hundred and fifty-nine adult Chinese type 2 diabetes patients were randomized to receive rapid-acting or sustained-release gliclazide therapy for 12 weeks. Their blood glucose levels were measured at 10 time points in a 24 h period before and after treatment, and the 24 h mean blood glucose levels were measured. Contribution of blood glucose levels to the mean blood glucose level and HbA1c was assessed by multiple regression analysis. The correlation coefficients of blood glucose level measured at 10 time points to the daily MBG were 0.58-0.74 and 0.59-0.79, respectively, before and after treatment (P<0.0001). The multiple stepwise regression analysis showed that the blood glucose levels measured at 6 of the 10 time points could explain 95% and 97% of the changes in MBG before and after treatment. The three blood glucose levels, which were measured at fasting, 2 h after breakfast and before dinner, of the 10 time points could explain 84% and 86% of the changes in MBG before and after treatment, but could only explain 36% and 26% of the changes in HbA1c before and after treatment, and they had a poorer correlation with the HbA1c than with the 24 h MBG. The blood glucose levels measured at fasting, 2 h after breakfast and before dinner truly reflected the change 24 h blood glucose level, suggesting that they are appropriate for the self-monitoring of blood glucose levels in diabetes patients receiving oral anti-diabetes therapy.

语种: 英语
WOS记录号: WOS:000341821000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62556
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100034, Peoples R China
2.China Japan Friendship Hosp, Beijing 100029, Peoples R China
3.Capital Med Univ, Affiliated Beijing Tongren Hosp, Beijing 100005, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Beijing 100853, Peoples R China

Recommended Citation:
Zhao Fang,Ma Yan Fen,Wen Jing Xiao,et al. Parsimonious Model for Blood Glucose Level Monitoring in Type 2 Diabetes patients[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(7):559-563.
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