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学科主题医学信息学
miR2Gene: pattern discovery of single gene, multiple genes, and pathways by enrichment analysis of their microRNA regulators
Qiu, Chengxiang1,2,3; Wang, Juan1,2,3; Cui, Qinghua1,2,3
刊名BMC SYSTEMS BIOLOGY
2011-12-14
DOI10.1186/1752-0509-5-S2-S9
suppl.2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mathematical & Computational Biology
资助者Natural Science Foundation of China ; Natural Science Foundation of China
研究领域[WOS]Mathematical & Computational Biology
关键词[WOS]INTEGRATED ANALYSIS ; EXPRESSION ; IMATINIB ; GENOMICS ; TARGETS ; TOOL
英文摘要

Background: In recent years, a number of tools have been developed to explore microRNAs (miRNAs) by analyzing their target genes. However, a reverse problem, that is, inferring patterns of protein-coding genes through their miRNA regulators, has not been explored. As various miRNA annotation data become available, exploring gene patterns by analyzing the prior knowledge of their miRNA regulators is becoming more feasible.

Results: In this study, we developed a tool, miR2Gene, for this purpose. Various sets of miRNAs, according to prior rules such as function, associated disease, tissue specificity, family, and cluster, were integrated with miR2Gene. For given genes, miR2Gene evaluates the enrichment of the predicted miRNAs that regulate them in each miRNA set. This tool can be used for single genes, multiple genes, and KEGG pathways. For the KEGG pathway, genes with enriched miRNA sets are highlighted according to various rules. We confirmed the usefulness of miR2Gene through case studies.

Conclusions: miR2Gene represents a novel and useful tool that integrates miRNA knowledge for protein-coding gene analysis. miR2Gene is freely available at http://cmbi.hsc.pku.edu.cn/mir2gene.

语种英语
所属项目编号30900829
资助者Natural Science Foundation of China ; Natural Science Foundation of China
WOS记录号WOS:000301987000009
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62557
专题基础医学院_医学信息学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100191, Peoples R China
2.Peking Univ, MOE Key Lab Mol cardiovasc Sci, Beijing 100191, Peoples R China
3.Inst Chem Def, Dept Chem Def, Beijing 102205, Peoples R China
推荐引用方式
GB/T 7714
Qiu, Chengxiang,Wang, Juan,Cui, Qinghua. miR2Gene: pattern discovery of single gene, multiple genes, and pathways by enrichment analysis of their microRNA regulators[J]. BMC SYSTEMS BIOLOGY,2011,suppl.2.
APA Qiu, Chengxiang,Wang, Juan,&Cui, Qinghua.(2011).miR2Gene: pattern discovery of single gene, multiple genes, and pathways by enrichment analysis of their microRNA regulators.BMC SYSTEMS BIOLOGY,suppl.2.
MLA Qiu, Chengxiang,et al."miR2Gene: pattern discovery of single gene, multiple genes, and pathways by enrichment analysis of their microRNA regulators".BMC SYSTEMS BIOLOGY suppl.2(2011).
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