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学科主题: 药物依赖
题名:
Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement
作者: Liu, Yu1; Le Foll, Bernard2; Liu, Yanli3; Wang, Xi1; Lu, Lin1
关键词: conditioned place preference ; rewarding effect ; ethanol ; nicotine ; caffeine
刊名: THESCIENTIFICWORLDJOURNAL
发表日期: 2008
DOI: 10.1100/tsw.2008.154
卷: 8, 页:1228-1245
收录类别: SCI ; SSCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Multidisciplinary Sciences
研究领域[WOS]: Environmental Sciences & Ecology ; Science & Technology - Other Topics
关键词[WOS]: VENTRAL TEGMENTAL AREA ; DOPAMINE D-3 RECEPTOR ; CALCIUM-CHANNEL ANTAGONISTS ; ETHANOL-RELATED BEHAVIORS ; RAT NUCLEUS-ACCUMBENS ; FREELY MOVING RATS ; KNOCK-OUT MICE ; NICOTINIC RECEPTORS ; LOCOMOTOR-ACTIVITY ; MOTIVATIONAL PROPERTIES
英文摘要:

The conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking. The vast majority of studies have focused on CPP induced by illicit drugs, such as psychostimulants and opioids. Although legal psychoactive drugs, such as ethanol, nicotine, and caffeine, are more widely used than illegal drugs, the establishment, extinction, and reinstatement of CPP produced by these licit drugs are less well understood. The present review discusses the extant research on CPP induced by legal drugs. We first describe the CPP model and discuss the behavioral procedures used to induce CPP for ethanol, nicotine, and caffeine. We then summarize the neuronal substrates that underlie CPP induced by these drugs from a genetic perspective. Finally, we draw on findings from pharmacological studies and discuss the neurotransmitters and neurohormones underlying CPP produced by ethanol, nicotine, and caffeine.

语种: 英语
WOS记录号: WOS:000261698000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62565
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Soochow Univ, Coll Pharm, Suzhou, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
3.Univ Toronto, Toronto, ON M5S 1A1, Canada

Recommended Citation:
Liu, Yu,Le Foll, Bernard,Liu, Yanli,et al. Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement[J]. THESCIENTIFICWORLDJOURNAL,2008,8:1228-1245.
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