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学科主题: 临床医学
题名:
Asymptomatic patients of chronic obstructive pulmonary disease in China
作者: Lu Ming3; Yao Wan-zhen3; Zhong Nan-shan1; Zhou Yu-min1; Wang Chen4; Chen Ping5; Kang Jian6; Huang Shao-guang7; Chen Bao-yuan8; Wang Chang-zheng9; Ni Dian-tao10; Wang Xiao-ping11; Wang Da-li12; Liu Sheng-ming1,13; Lue Jia-chun2; Shen Ning3; Ding Yan-ling3; Ran Pi-xin1
关键词: chronic bronchitis ; chronic obstructive pulmonary disease ; respiratory ; spirometry ; screening
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-06-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.12.002
卷: 123, 期:12, 页:1494-1499
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: AIR-FLOW OBSTRUCTION ; RESPIRATORY SYMPTOMS ; GENERAL-POPULATION ; CHRONIC-BRONCHITIS ; UNITED-STATES ; COPD ; HEALTH ; ADULTS ; ASTHMA ; PREVALENCE
英文摘要:

Background Chronic obstructive pulmonary disease (COPD) has a variable natural history and not all individuals follow the same course. This study aimed to identify the prevalence and characteristics of asymptomatic COPD patients from a population-based survey in China.

Methods A multistage cluster sampling strategy was used in a population from seven different provinces/cities. All residents (over 40 years old) were interviewed with a standardized questionnaire and spirometry. Post-bronchodilator forced expiratory volume in 1 second (FEV(1))/forced vital capacity (FVC) of less than 70% was defined as the diagnostic criterion of COPD. All COPD patients screened were divided into symptomatic group and asymptomatic group according to the presence or absence of chronic respiratory symptoms. Socio-demographic, personal and exposure variables were collected and analyzed.

Results Among the 1668 patients who were diagnosed with COPD from the 25 627 sampling subjects, 589 (35.3%) were asymptomatic. The age, sex, body mass index (BM, rural and urban distributions, smoking habit and education levels were similar in the two groups. A total of 64.7% of the asymptomatic patients had no comorbidities. Cardiovascular diseases and lung cancer were more common among symptomatic COPD patients than asymptomatic group. Asymptomatic COPD group were less likely to present with poor ventilation in the kitchen, a family history of respiratory disease and recurrent childhood cough. Asymptomatic COPD patients had significantly higher FEV, (73.1% vs. 61.0%), FVC (91.9% vs. 82.0%), and a higher ratio of FEV(1)/FVC (62.9% vs. 58.7%) (all P <0.001) than symptomatic group. More asymptomatic patients were underdiagnosed (91.9% vs. 54.3%, P <0.001) than symptomatic patients.

Conclusions This large population-based survey confirmed a high prevalence of asymptomatic COPD patients in China. More use of spirometry screening test may be important to the early detection of COPD. Chin Med J 2010;123(12):1494-1499

语种: 英语
所属项目编号: 2001BA703B03 ; B30301
项目资助者: Chinese Central Government ; Guangdong Key Research Project
WOS记录号: WOS:000279754100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62569
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis,Dept Resp Med, State Key Lab Resp Dis, Guangzhou 510182, Guangdong, Peoples R China
2.Guangzhou Med Univ, Dept Epidemiol, Guangzhou 510182, Guangdong, Peoples R China
3.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100191, Peoples R China
4.Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp Med, Beijing Inst Resp Med, Beijing 100020, Peoples R China
5.Shenyang Mil Gen Hosp, Dept Resp Med, Shenyang 110016, Liaoning, Peoples R China
6.China Med Univ, Dept Resp Med, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Resp Med, Shanghai 200025, Peoples R China
8.Tianjin Med Univ, Gen Hosp, Dept Resp Med, Tianjin 300052, Peoples R China
9.Third Mil Med Univ, Xinqiao Hosp, Dept Resp Med, Chongqing 400037, Peoples R China
10.Fourth Mil Med Univ, Xijing Hosp, Dept Resp Med, Xian 710032, Shaanxi, Peoples R China
11.First Municipal People Hosp Shaoguan, Dept Resp Med, Shaoguan 512000, Guangdong, Peoples R China
12.Second Hosp Liwan Dist Guangzhou, Dept Resp Med, Guangzhou 510160, Guangdong, Peoples R China
13.Jinan Univ, Affiliated Hosp 1, Dept Resp Med, Guangzhou 510630, Guangdong, Peoples R China

Recommended Citation:
Lu Ming,Yao Wan-zhen,Zhong Nan-shan,et al. Asymptomatic patients of chronic obstructive pulmonary disease in China[J]. CHINESE MEDICAL JOURNAL,2010,123(12):1494-1499.
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