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学科主题: 临床医学
题名:
One-stage human acellular nerve allograft reconstruction for digital nerve defects
作者: Li, Xue-yuan1; Hu, Hao-liang1; Fei, Jian-rong1; Wang, Xin1; Wang, Tian-bing2; Zhang, Pei-xun2; Chen, Hong1
关键词: nerve regeneration ; peripheral nerve ; allograft ; digital nerve ; nerve conduit ; nerve reconstruction ; nerve defect ; sensory nerve ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2015
DOI: 10.4103/1673-5374.150712
卷: 10, 期:1, 页:95-98
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: CONDUITS ; REPAIR ; TRANSPLANTATION ; REGENERATION ; GRAFT
英文摘要:

Human acellular nerve allografts have a wide range of donor origin and can effectively avoid nerve injury in the donor area. Very little is known about one-stage reconstruction of digital nerve defects. The present study observed the feasibility and effectiveness of human acellular nerve allograft in the reconstruction of < 5-cm digital nerve defects within 6 hours after injury. A total of 15 cases of nerve injury, combined with nerve defects in 18 digits from the Department of Emergency were enrolled in this study. After debridement, digital nerves were reconstructed using human acellular nerve allografts. The patients were followed up for 6-24 months after reconstruction. Mackinnon-Dellon static two-point discrimination results showed excellent and good rates of 89%. Semmes-Weinstein monofilament test demonstrated that light touch was normal, with an obvious improvement rate of 78%. These findings confirmed that human acellular nerve allograft for one-stage reconstruction of digital nerve defect after hand injury is feasible, which provides a novel trend for peripheral nerve reconstruction.

语种: 英语
所属项目编号: 2014CB542200
项目资助者: National Program on Key Basic Research Project of China (973 Program)
WOS记录号: WOS:000350098100024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62571
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Ningbo 6 Hosp, Dept Hand Surg, Ningbo, Zhejiang, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China

Recommended Citation:
Li, Xue-yuan,Hu, Hao-liang,Fei, Jian-rong,et al. One-stage human acellular nerve allograft reconstruction for digital nerve defects[J]. NEURAL REGENERATION RESEARCH,2015,10(1):95-98.
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