IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis
Chen, Yuqing10; Lipkowitz, Michael S.5; Salem, Rany M.; Fung, Maple M.; Bhatnagar, Vibha3; Mahata, Manjula; Nievergelt, Caroline M.2; Rao, Fangwen; Mahata, Sushil K.8; Schork, Nicholas J.6; Hicks, Pamela J.9; Bowden, Donald W.9; Freedman, Barry I.9; Brophy, Victoria H.7; O′ Connor, Daniel T.1,4,8; AASK Co Investigators
关键词Adrenergic genetic influence African-American Study of Kidney Disease Chronic kidney disease End-stage renal disease Glomerular filtration rate Hypertensive nephrosclerosis
刊名AMERICAN JOURNAL OF NEPHROLOGY
2010
DOI10.1159/000313927
32期:1页:23-30
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]STAGE RENAL-DISEASE ; BLOOD-PRESSURE CONTROL ; AFRICAN-AMERICAN ; TYROSINE-HYDROXYLASE ; RECEPTOR GENE ; FAMILIAL RISK ; AASK TRIAL ; POLYMORPHISMS ; HAPLOTYPES ; STRESS
英文摘要

Background: African-Americans are likely to develop hypertension and hypertensive nephrosclerosis. This grave prognosis, coupled with familial aggregation of end-stage renal disease (ESRD) in Blacks, prompts a search for genetic risk factors for ESRD. Recent evidence implicates a crucial role for the sympathetic nervous system in progressive renal disease. Methods: We used the African-American Study of Kidney Disease to probe whether beta(2)-adrenergic receptor (ADRB2) predicts glomerular filtration rate (GFR) decline rate. A total of 580 participants were included. Baseline GFR was 51.2 +/- 0.5 ml/min/1.73 m(2). Subjects were randomized in a 2 x 3 block design: to intensively lowered (MAP <= 92 mm Hg) versus ′usual′ (MAP = 102-107 mm Hg) blood pressure goal groups, and also divided by three randomized antihypertensive drugs (ramipril, metoprolol, or amlodipine). We scored 4 SNPs at the ADRB2 locus. Results: Haplotypes at ADRB2 predicted chronic GFR decline rate, GFR declined more slowely in individuals with haplotype-1 (-804G -> 173T -> 16Gly -> 27Gln), and faster in those who carried haplotype-3 (-804G -> 173T -> 16Arg -> 27Gln). ADRB2 genotype interacted with antihypertensive drug class to influence GFR slope (p = 0.001-0.037). We extended our findings to an independent case/control sample of Black hypertensive ESRD, in which we found that variant Gly16Arg that tagged the GFR slope-determining ADRB2 haplotype also conferred risk for the ESRD trait in Blacks. Conclusions: The GFR decline/progression rate in hypertensive renal disease is controlled in part by genetic variation within the adrenergic pathway. Copyright (C) 2010 S. Karger AG, Basel

语种英语
WOS记录号WOS:000278684800004
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62573
专题北京大学第一临床医学院_肾脏内科
作者单位1.Mt Sinai Sch Med, Div Renal, New York, NY USA
2.Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA
3.Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
4.Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA
6.Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
7.Roche Mol Syst, Dept Human Genet, Alameda, CA USA
8.VA San Diego Healthcare Syst, San Diego, CA USA
9.Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA
10.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yuqing,Lipkowitz, Michael S.,Salem, Rany M.,et al. Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis[J]. AMERICAN JOURNAL OF NEPHROLOGY,2010,32(1):23-30.
APA Chen, Yuqing.,Lipkowitz, Michael S..,Salem, Rany M..,Fung, Maple M..,Bhatnagar, Vibha.,...&AASK Co Investigators.(2010).Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis.AMERICAN JOURNAL OF NEPHROLOGY,32(1),23-30.
MLA Chen, Yuqing,et al."Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis".AMERICAN JOURNAL OF NEPHROLOGY 32.1(2010):23-30.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Yuqing]的文章
[Lipkowitz, Michael S.]的文章
[Salem, Rany M.]的文章
百度学术
百度学术中相似的文章
[Chen, Yuqing]的文章
[Lipkowitz, Michael S.]的文章
[Salem, Rany M.]的文章
必应学术
必应学术中相似的文章
[Chen, Yuqing]的文章
[Lipkowitz, Michael S.]的文章
[Salem, Rany M.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。