北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis
作者: Chen, Yuqing10; Lipkowitz, Michael S.5; Salem, Rany M.; Fung, Maple M.; Bhatnagar, Vibha3; Mahata, Manjula; Nievergelt, Caroline M.2; Rao, Fangwen; Mahata, Sushil K.8; Schork, Nicholas J.6; Hicks, Pamela J.9; Bowden, Donald W.9; Freedman, Barry I.9; Brophy, Victoria H.7; O′ Connor, Daniel T.1,4,8; AASK Co Investigators
关键词: Adrenergic genetic influence ; African-American Study of Kidney Disease ; Chronic kidney disease ; End-stage renal disease ; Glomerular filtration rate ; Hypertensive nephrosclerosis
刊名: AMERICAN JOURNAL OF NEPHROLOGY
发表日期: 2010
DOI: 10.1159/000313927
卷: 32, 期:1, 页:23-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: STAGE RENAL-DISEASE ; BLOOD-PRESSURE CONTROL ; AFRICAN-AMERICAN ; TYROSINE-HYDROXYLASE ; RECEPTOR GENE ; FAMILIAL RISK ; AASK TRIAL ; POLYMORPHISMS ; HAPLOTYPES ; STRESS
英文摘要:

Background: African-Americans are likely to develop hypertension and hypertensive nephrosclerosis. This grave prognosis, coupled with familial aggregation of end-stage renal disease (ESRD) in Blacks, prompts a search for genetic risk factors for ESRD. Recent evidence implicates a crucial role for the sympathetic nervous system in progressive renal disease. Methods: We used the African-American Study of Kidney Disease to probe whether beta(2)-adrenergic receptor (ADRB2) predicts glomerular filtration rate (GFR) decline rate. A total of 580 participants were included. Baseline GFR was 51.2 +/- 0.5 ml/min/1.73 m(2). Subjects were randomized in a 2 x 3 block design: to intensively lowered (MAP <= 92 mm Hg) versus ′usual′ (MAP = 102-107 mm Hg) blood pressure goal groups, and also divided by three randomized antihypertensive drugs (ramipril, metoprolol, or amlodipine). We scored 4 SNPs at the ADRB2 locus. Results: Haplotypes at ADRB2 predicted chronic GFR decline rate, GFR declined more slowely in individuals with haplotype-1 (-804G -> 173T -> 16Gly -> 27Gln), and faster in those who carried haplotype-3 (-804G -> 173T -> 16Arg -> 27Gln). ADRB2 genotype interacted with antihypertensive drug class to influence GFR slope (p = 0.001-0.037). We extended our findings to an independent case/control sample of Black hypertensive ESRD, in which we found that variant Gly16Arg that tagged the GFR slope-determining ADRB2 haplotype also conferred risk for the ESRD trait in Blacks. Conclusions: The GFR decline/progression rate in hypertensive renal disease is controlled in part by genetic variation within the adrenergic pathway. Copyright (C) 2010 S. Karger AG, Basel

语种: 英语
所属项目编号: MD000220 ; RR00827
项目资助者: NIH/NCMHD, EXPORT Minority Health Center ; NIH/NCRR, General Clinical Research Center ; National Institutes of Health, Department of Veterans Affairs ; International Society of Nephrology
WOS记录号: WOS:000278684800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62573
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Mt Sinai Sch Med, Div Renal, New York, NY USA
2.Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA
3.Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
4.Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA
6.Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
7.Roche Mol Syst, Dept Human Genet, Alameda, CA USA
8.VA San Diego Healthcare Syst, San Diego, CA USA
9.Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA
10.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Yuqing,Lipkowitz, Michael S.,Salem, Rany M.,et al. Progression of Chronic Kidney Disease: Adrenergic Genetic Influence on Glomerular Filtration Rate Decline in Hypertensive Nephrosclerosis[J]. AMERICAN JOURNAL OF NEPHROLOGY,2010,32(1):23-30.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Yuqing]'s Articles
[Lipkowitz, Michael S.]'s Articles
[Salem, Rany M.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Yuqing]‘s Articles
[Lipkowitz, Michael S.]‘s Articles
[Salem, Rany M.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace