IR@PKUHSC  > 北京大学第二临床医学院  > 眼科
学科主题临床医学
Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese
Cheng, Y.1; Li, M. W.1; Li, H. P.2; Zeng, W. T.3; Zhou, P.4; Huang, L. Z.1; Li, X. X.1; Sun, Y. Y.1
关键词Neovascular age-related macular degeneration TLR3 Polypoidal choroidal vasculopathy Single nucleotide polymorphism
刊名GENETICS AND MOLECULAR RESEARCH
2014
DOI10.4238/2014.January.17.15
13期:1页:302-309
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
资助者National Basic Research Program of China ("973" Program) ; National Natural Science Foundation of China (NSFC) ; Research Fund for Science and Technology Program of Beijing ; National Basic Research Program of China ("973" Program) ; National Natural Science Foundation of China (NSFC) ; Research Fund for Science and Technology Program of Beijing
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]COMPLEMENT FACTOR-H ; DOUBLE-STRANDED-RNA ; GEOGRAPHIC ATROPHY ; GENE ; MACULOPATHY ; POPULATION ; ACTIVATION ; SUSCEPTIBILITY ; GROWTH ; RISK
英文摘要

Toll-like receptor 3 (TLR3) variants in mainland northern Chinese patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) were investigated. The complete genes of TLR3, including all exons and the promoter region, were assessed using direct sequencing technology of 284 unrelated mainland northern Chinese individuals: 96 nAMD patients, 92 PCV patients, and 96 controls. Six single nucleotide polymorphisms were identified: rs5743303, rs5743305, rs5743312, rs3775291, rs3775290, and rs6830345. The distribution of TLR3 genotypes for nAMD and PCV was not significantly different compared with normal controls. This study indicates that the TLR3 gene polymorphism is not associated with nAMD and PCV in northern Chinese patients.

语种英语
所属项目编号2011CB510200 ; 81100666 ; Z121100005312006
资助者National Basic Research Program of China ("973" Program) ; National Natural Science Foundation of China (NSFC) ; Research Fund for Science and Technology Program of Beijing ; National Basic Research Program of China ("973" Program) ; National Natural Science Foundation of China (NSFC) ; Research Fund for Science and Technology Program of Beijing
WOS记录号WOS:000331846400033
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62574
Collection北京大学第二临床医学院_眼科
作者单位1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Ctr Eye,Minist Educ, Dept Ophthalmol,Key Lab Vis Loss & Restorat, Beijing 100871, Peoples R China
3.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
4.Fudan Univ, Eye & ENT Hosp, Dept Ophthalmol, Shanghai 200433, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Y.,Li, M. W.,Li, H. P.,et al. Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese[J]. GENETICS AND MOLECULAR RESEARCH,2014,13(1):302-309.
APA Cheng, Y..,Li, M. W..,Li, H. P..,Zeng, W. T..,Zhou, P..,...&Sun, Y. Y..(2014).Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese.GENETICS AND MOLECULAR RESEARCH,13(1),302-309.
MLA Cheng, Y.,et al."Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese".GENETICS AND MOLECULAR RESEARCH 13.1(2014):302-309.
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