IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus
Shi, Xue Ying1,2; Bhagwandeen, Brahin1; Leong, Anthony S. -Y.1
关键词Barrett esophagus intestinal metaplasia CDX2 villin HepPar-1 cytokeratin 7 immunohistochemistry
刊名AMERICAN JOURNAL OF CLINICAL PATHOLOGY
2008-04-01
DOI10.1309/UWK3NAHV31GFHM3J
129期:4页:571-577
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]HOMEODOMAIN PROTEIN CDX2 ; COLUMNAR-LINED ESOPHAGUS ; GASTROESOPHAGEAL JUNCTION ; ENDOSCOPIC SURVEILLANCE ; RISING INCIDENCE ; GASTRIC CARDIA ; EXPRESSION ; ADENOCARCINOMA ; DIFFERENTIATION ; MUCOSA
英文摘要

The identification of intestinal metaplasia (IM) in the esophagus is necessary for the selection of patients with Barrett esophagus (BE)for surveillance. We studied 108 esophageal biopsy and resection specimens, clinically diagnosed as BE, and stained them for CDX2, villin, HepPar-1, and cytokeratin (CK) 7 to investigate sensitivily for identifying IM. H&E-stained sections showed definite goblet cells in 94 cases. CDX2 and villin were positive in all 94 cases. Of 38 cardia- and 9 fundic-type mucosa samples associated with BE, 13 (34%) and 0 (0%) displayed CDX2 positivity and 21 (55%) and 1 (11%) displayed villin positivity, respectively. HepPar-1 was positive in 54 (57%) of 94 cases with IM and negative in the associated cardia- and fundic-type mucosa. A full-thickness CK7 staining pattern was present in 90 (96%) of samples with IM and 22 (58%) and 0 (0%) of the associated cardia- and fundic-type mucosa, respectively. None of 20 control samples of morphologically normal gastric mucosa stained for CDX2 or villin. CDX2 and villin are sensitive markers for early-stage IM and can supplement the histologic identification of this premalignant condition in the esophagus.

语种英语
WOS记录号WOS:000254127600008
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62575
专题北京大学基础医学院_病理学系
作者单位1.Hunter Reg Mail Ctr, Hunter Area Pathol Serv, Div Anat Pathol, Newcastle, NSW 2310, Australia
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Shi, Xue Ying,Bhagwandeen, Brahin,Leong, Anthony S. -Y.. CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY,2008,129(4):571-577.
APA Shi, Xue Ying,Bhagwandeen, Brahin,&Leong, Anthony S. -Y..(2008).CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus.AMERICAN JOURNAL OF CLINICAL PATHOLOGY,129(4),571-577.
MLA Shi, Xue Ying,et al."CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus".AMERICAN JOURNAL OF CLINICAL PATHOLOGY 129.4(2008):571-577.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
CDX2 and villin are (6644KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, Xue Ying]的文章
[Bhagwandeen, Brahin]的文章
[Leong, Anthony S. -Y.]的文章
百度学术
百度学术中相似的文章
[Shi, Xue Ying]的文章
[Bhagwandeen, Brahin]的文章
[Leong, Anthony S. -Y.]的文章
必应学术
必应学术中相似的文章
[Shi, Xue Ying]的文章
[Bhagwandeen, Brahin]的文章
[Leong, Anthony S. -Y.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。