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学科主题: 基础医学
题名:
CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus
作者: Shi, Xue Ying1,2; Bhagwandeen, Brahin1; Leong, Anthony S. -Y.1
关键词: Barrett esophagus ; intestinal metaplasia ; CDX2 ; villin ; HepPar-1 ; cytokeratin 7 ; immunohistochemistry
刊名: AMERICAN JOURNAL OF CLINICAL PATHOLOGY
发表日期: 2008-04-01
DOI: 10.1309/UWK3NAHV31GFHM3J
卷: 129, 期:4, 页:571-577
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: HOMEODOMAIN PROTEIN CDX2 ; COLUMNAR-LINED ESOPHAGUS ; GASTROESOPHAGEAL JUNCTION ; ENDOSCOPIC SURVEILLANCE ; RISING INCIDENCE ; GASTRIC CARDIA ; EXPRESSION ; ADENOCARCINOMA ; DIFFERENTIATION ; MUCOSA
英文摘要:

The identification of intestinal metaplasia (IM) in the esophagus is necessary for the selection of patients with Barrett esophagus (BE)for surveillance. We studied 108 esophageal biopsy and resection specimens, clinically diagnosed as BE, and stained them for CDX2, villin, HepPar-1, and cytokeratin (CK) 7 to investigate sensitivily for identifying IM. H&E-stained sections showed definite goblet cells in 94 cases. CDX2 and villin were positive in all 94 cases. Of 38 cardia- and 9 fundic-type mucosa samples associated with BE, 13 (34%) and 0 (0%) displayed CDX2 positivity and 21 (55%) and 1 (11%) displayed villin positivity, respectively. HepPar-1 was positive in 54 (57%) of 94 cases with IM and negative in the associated cardia- and fundic-type mucosa. A full-thickness CK7 staining pattern was present in 90 (96%) of samples with IM and 22 (58%) and 0 (0%) of the associated cardia- and fundic-type mucosa, respectively. None of 20 control samples of morphologically normal gastric mucosa stained for CDX2 or villin. CDX2 and villin are sensitive markers for early-stage IM and can supplement the histologic identification of this premalignant condition in the esophagus.

语种: 英语
WOS记录号: WOS:000254127600008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62575
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Hunter Reg Mail Ctr, Hunter Area Pathol Serv, Div Anat Pathol, Newcastle, NSW 2310, Australia
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Shi, Xue Ying,Bhagwandeen, Brahin,Leong, Anthony S. -Y.. CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY,2008,129(4):571-577.
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