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学科主题: 临床医学
题名:
Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross- sectional study
作者: Li, Rong1; Yu, Geng1; Yang, Dongzi2; Li, Shangwei3; Lu, Shulan4; Wu, Xiaoke5; Wei, Zhaolian6; Song, Xueru7; Wang, Xiuxia8; Fu, Shuxin9; Qiao, Jie1
关键词: Prevalence ; Predictor ; Metabolic abnormalities ; PCOS ; Community
刊名: BMC ENDOCRINE DISORDERS
发表日期: 2014-09-16
DOI: 10.1186/1472-6823-14-76
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: POLYCYSTIC-OVARY-SYNDROME ; IMPAIRED GLUCOSE-TOLERANCE ; DIAGNOSTIC-CRITERIA ; INSULIN-RESISTANCE ; CONSENSUS ; RISKS
英文摘要:

Background: Polycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.61% of Chinese women of reproductive age, but little is known about the prevalence and predictors in Chinese PCOS patients. This study aimed to determine the prevalence and predictors of the metabolic abnormalities in Chinese women with and without PCOS.

Methods: A large-scale national epidemiological investigation was conducted in reproductive age women (19 to 45 years) across China. 833 reproductive aged PCOS women, who participated in the healthcare screening, were recruited from ten provinces in China. Clinical history, ultrasonographic exam (ovarian follicle), hormonal and metabolic parameters were the main outcome measures.

Results: The prevalence of metabolic syndrome (MetS) as compared in PCOS and non-PCOS women from community were 18.2% vs 14.7%, and IR (insulin resistance) were 14.2% vs 9.3% (p < 0.001) respectively. After adjusting for age, the indicators (central obesity, hypertension, fasting insulin, SHBG, dyslipinaemia) for metabolic disturbances were significantly higher in PCOS than in non-PCOS groups. Using multivariate logistic regression, central obesity and FAI were risk factors, while SHBG was a protective factor on the occurrence of Mets and IR in PCOS women (OR: 1.132, 1.105 and 0.995).

Conclusions: The risk factors of the metabolic syndrome and insulin resistance were BMI and FAI for PCOS women, respectively. The decrease of SHBG level was also a risk factor for insulin resistance in both PCOS and metabolic disturbance.

语种: 英语
项目资助者: National Science Fund ; Capital Medical Development Scientific Research Fund ; National Key Technology RD Program
WOS记录号: WOS:000342024100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62577
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Reprod Med Ctr, Beijing 100191, Peoples R China
2.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
3.Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Reprod Med Ctr, Chengdu 610064, Peoples R China
4.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Xian 710049, Peoples R China
5.Heilongjiang Chinese Med Univ, Affiliated Hosp 1, Dept Obstet & Gyneocol, Harbin, Peoples R China
6.Anhui Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Hefei, Anhui, Peoples R China
7.Tianjin Med Univ Gen Hosp, Dept Obstet & Gynecol, Heping, Peoples R China
8.China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Peoples R China
9.Central South Univ, Dept Obstet & Gynecol, Xiangya Hosp 2, Changsha, Hunan, Peoples R China

Recommended Citation:
Li, Rong,Yu, Geng,Yang, Dongzi,et al. Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross- sectional study[J]. BMC ENDOCRINE DISORDERS,2014,14.
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