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学科主题: 临床医学
题名:
Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility
作者: Sun, Jiufeng1,3; Zhang, Junmin1; Najafzadeh, M. J.3,4,5; Badali, Hamid2,3,4; Li, Xiqing1; Xi, Liyan1; de Hoog, G. S.1,3,4,6
关键词: Melanin ; Mutant ; Fonsecaea monophora
刊名: MYCOPATHOLOGIA
发表日期: 2011-11-01
DOI: 10.1007/s11046-011-9439-1
卷: 172, 期:5, 页:373-380
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: MELANIN-LIKE PIGMENTS ; IN-VITRO ; CRYPTOCOCCUS-NEOFORMANS ; PARACOCCIDIOIDES-BRASILIENSIS ; WANGIELLA-DERMATITIDIS ; PATHOGENIC FUNGI ; SCLEROTIC CELLS ; PEDROSOI ; BIOSYNTHESIS ; INFECTION
英文摘要:

Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of Fonsecaea monophora from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin and another (CBS 125149) lacked melanin, grew faster than a mutant with cell-wall-associated and secreted melanin (CBS 125188) and than the meristematic parent strain (CBS 122845) (P < 0.05). The albino strains were also more sensitive to low pH, high UV radiation, and oxidative stress (P < 0.05). However, susceptibility testing against eight antifungal agents showed no statistical difference (P > 0.05). The discovery of three melanin mutants of a single meristematic mutant provided an alternative way to study the role of cell-wall-associated and secreted melanins in the pathogenesis of black fungi.

语种: 英语
所属项目编号: 20100171110068
项目资助者: Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000297626000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62580
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
2.Mashhad Univ Med Sci, Dept Parasitol & Mycol, Mashhad, Iran
3.Sun Yat Sen Univ, Dept Dermatol, Sun Yat Sen Mem Hosp, Guangzhou 510120, Peoples R China
4.Mazandaran Univ Med Sci, Dept Med Mycol & Parasitol, Sch Med, Mol & Cell Biol Res Ctr, Sari, Iran
5.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
6.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Jiufeng,Zhang, Junmin,Najafzadeh, M. J.,et al. Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility[J]. MYCOPATHOLOGIA,2011,172(5):373-380.
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