IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility
Sun, Jiufeng1,3; Zhang, Junmin1; Najafzadeh, M. J.3,4,5; Badali, Hamid2,3,4; Li, Xiqing1; Xi, Liyan1; de Hoog, G. S.1,3,4,6
关键词Melanin Mutant Fonsecaea monophora
刊名MYCOPATHOLOGIA
2011-11-01
DOI10.1007/s11046-011-9439-1
172期:5页:373-380
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]MELANIN-LIKE PIGMENTS ; IN-VITRO ; CRYPTOCOCCUS-NEOFORMANS ; PARACOCCIDIOIDES-BRASILIENSIS ; WANGIELLA-DERMATITIDIS ; PATHOGENIC FUNGI ; SCLEROTIC CELLS ; PEDROSOI ; BIOSYNTHESIS ; INFECTION
英文摘要

Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of Fonsecaea monophora from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin and another (CBS 125149) lacked melanin, grew faster than a mutant with cell-wall-associated and secreted melanin (CBS 125188) and than the meristematic parent strain (CBS 122845) (P < 0.05). The albino strains were also more sensitive to low pH, high UV radiation, and oxidative stress (P < 0.05). However, susceptibility testing against eight antifungal agents showed no statistical difference (P > 0.05). The discovery of three melanin mutants of a single meristematic mutant provided an alternative way to study the role of cell-wall-associated and secreted melanins in the pathogenesis of black fungi.

语种英语
WOS记录号WOS:000297626000005
项目编号20100171110068
资助机构Research Fund for the Doctoral Program of Higher Education of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62580
专题北京大学第一临床医学院_皮肤性病科
作者单位1.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
2.Mashhad Univ Med Sci, Dept Parasitol & Mycol, Mashhad, Iran
3.Sun Yat Sen Univ, Dept Dermatol, Sun Yat Sen Mem Hosp, Guangzhou 510120, Peoples R China
4.Mazandaran Univ Med Sci, Dept Med Mycol & Parasitol, Sch Med, Mol & Cell Biol Res Ctr, Sari, Iran
5.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
6.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
推荐引用方式
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Sun, Jiufeng,Zhang, Junmin,Najafzadeh, M. J.,et al. Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility[J]. MYCOPATHOLOGIA,2011,172(5):373-380.
APA Sun, Jiufeng.,Zhang, Junmin.,Najafzadeh, M. J..,Badali, Hamid.,Li, Xiqing.,...&de Hoog, G. S..(2011).Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility.MYCOPATHOLOGIA,172(5),373-380.
MLA Sun, Jiufeng,et al."Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility".MYCOPATHOLOGIA 172.5(2011):373-380.
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