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学科主题: 药学
题名:
Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
作者: Liu, Guoqiang1; Dong, Jing2; Wang, Hong1; Hashi, Yuki2; Chen, Shizhong1
关键词: Sophora flavescens Ait. ; Alkaloids ; Electrospray ionization ; High-performance liquid chromatography ; Mass spectrometry
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2011-04-05
DOI: 10.1016/j.jpba.2010.12.024
卷: 54, 期:5, 页:1065-1072
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: QUINOLIZIDINE ALKALOIDS ; CAPILLARY-ELECTROPHORESIS ; MATRINE ; FINGERPRINT ; FLAVONOIDS ; OXYMATRINE ; EXTRACTS ; HPLC
英文摘要:

Sophora flavescens Ait., a well-known Chinese herbal medicine, is widely used in clinical practice for the treatment of viral hepatitis, cancer, gastrointestinal hemorrhage, and skin diseases. This paper is the first report on a method based on the combined use of high-performance liquid chromatography, photodiode array detection, and electrospray ionization tandem mass spectrometry for the comprehensive and systematic separation and characterization of bioactive alkaloids in Sophora flavescens Ait. A total of 22 constituents were identified on the basis of the extracted ion chromatograms for different [M+H](+) ions of the alkaloids present in S. flavescens Ait. Among these, 5 constituents were unambiguously identified by comparing the experimental data on their retention times and MSn spectra with those of the authentic compounds, and 17 other constituents were tentatively identified on the basis of their MSn fragmentation behaviors and/or molecular weight information from literatures. Furthermore, some characteristic fragmentation pathways of the alkaloids in S. flavescens Ait. were detected and examined. This information may be useful for characterizing the bioactive alkaloids present in S. flavescens Ait. and for possible applications in formulations. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000286952100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62583
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Shimadzu Int Trading Shanghai Co Ltd, Beijing 100020, Peoples R China

Recommended Citation:
Liu, Guoqiang,Dong, Jing,Wang, Hong,et al. Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,54(5):1065-1072.
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