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Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
Liu, Guoqiang1; Dong, Jing2; Wang, Hong1; Hashi, Yuki2; Chen, Shizhong1
关键词Sophora flavescens Ait. Alkaloids Electrospray ionization High-performance liquid chromatography Mass spectrometry
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011-04-05
DOI10.1016/j.jpba.2010.12.024
54期:5页:1065-1072
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]QUINOLIZIDINE ALKALOIDS ; CAPILLARY-ELECTROPHORESIS ; MATRINE ; FINGERPRINT ; FLAVONOIDS ; OXYMATRINE ; EXTRACTS ; HPLC
英文摘要

Sophora flavescens Ait., a well-known Chinese herbal medicine, is widely used in clinical practice for the treatment of viral hepatitis, cancer, gastrointestinal hemorrhage, and skin diseases. This paper is the first report on a method based on the combined use of high-performance liquid chromatography, photodiode array detection, and electrospray ionization tandem mass spectrometry for the comprehensive and systematic separation and characterization of bioactive alkaloids in Sophora flavescens Ait. A total of 22 constituents were identified on the basis of the extracted ion chromatograms for different [M+H](+) ions of the alkaloids present in S. flavescens Ait. Among these, 5 constituents were unambiguously identified by comparing the experimental data on their retention times and MSn spectra with those of the authentic compounds, and 17 other constituents were tentatively identified on the basis of their MSn fragmentation behaviors and/or molecular weight information from literatures. Furthermore, some characteristic fragmentation pathways of the alkaloids in S. flavescens Ait. were detected and examined. This information may be useful for characterizing the bioactive alkaloids present in S. flavescens Ait. and for possible applications in formulations. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000286952100020
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62583
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Shimadzu Int Trading Shanghai Co Ltd, Beijing 100020, Peoples R China
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GB/T 7714
Liu, Guoqiang,Dong, Jing,Wang, Hong,et al. Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,54(5):1065-1072.
APA Liu, Guoqiang,Dong, Jing,Wang, Hong,Hashi, Yuki,&Chen, Shizhong.(2011).Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,54(5),1065-1072.
MLA Liu, Guoqiang,et al."Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 54.5(2011):1065-1072.
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