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学科主题: 临床医学
题名:
Mineral and bone disorder in Chinese dialysis patients: a multicenter study
作者: Kong, Xianglei1,2,3,4,30; Zhang, Luxia1,2,3,4; Zhang, Ling6; Chen, Nan7; Gu, Yong8; Yu, Xueqing9; Liu, Wenhu10; Chen, Jianghua11; Peng, Liren12; Yuan, Weijie13; Wu, Hua14; Chen, Wei15; Fan, Minhua16; He, Liqun17; Ding, Feng18; Chen, Xiangmei19; Xiong, Zuying20; Zhang, Jinyuan21; Jia, Qiang22; Shi, Wei23; Xing, Changying24; Tang, Xiaoling25; Hou, Fanfan26; Shu, Guiyang27; Mei, Changlin28; Wang, Li29; Xu, Dongmei30; Ni, Zhaohui31; Zuo, Li1,2,3,4; Wang, Mei1,2,3,4,5,32,33,34; Wang, Haiyan1,2,3,4
关键词: End stage renal disease ; Mineral and bone disorder ; Epidemiology
刊名: BMC NEPHROLOGY
发表日期: 2012-09-21
DOI: 10.1186/1471-2369-13-116
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; HEMODIALYSIS-PATIENTS ; CONVENTIONAL HEMODIALYSIS ; MAINTENANCE HEMODIALYSIS ; SERUM PHOSPHORUS ; METABOLISM ; CALCIUM ; PHOSPHATE ; RISK ; ASSOCIATION
英文摘要:

Background: Mineral and bone disorder (MBD) in patients with chronic kidney disease is associated with increased morbidity and mortality. Studies regarding the status of MBD treatment in developing countries, especially in Chinese dialysis patients are extremely limited.

Methods: A cross-sectional study of 1711 haemodialysis (HD) patients and 363 peritoneal dialysis (PD) patients were enrolled. Parameters related to MBD, including serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH) were analyzed. The achievement of MBD targets was compared with the results from the Dialysis Outcomes and Practice Study (DOPPS) 3 and DOPPS 4. Factors associated with hyperphosphatemia were examined.

Results: Total 2074 dialysis patients from 28 hospitals were involved in this study. Only 38.5%, 39.6% and 26.6% of them met the Kidney Disease Outcomes Quality Initiative (K/DOQI) defined targets for serum P, Ca and iPTH levels. Serum P and Ca levels were statistically higher (P < 0.05) in the HD patients compared with those of PD patients, which was (6.3 +/- 2.1) mg/dL vs (5.7 +/- 2.0) mg/dL and (9.3 +/- 1.1) mg/dL vs (9.2 +/- 1.1) mg/dL, respectively. Serum iPTH level were statistically higher in the PD patients compared with those of HD patients (P = 0.03). The percentage of patients reached the K/DOQI targets for P (37.6% vs 49.8% vs 54.5%, P < 0.01), Ca (38.6% vs 50.4% vs 56.0%, P < 0.01) and iPTH (26.5% vs 31.4% vs 32.1%, P < 0.01) were lower among HD patients, compared with the data from DOPPS 3 and DOPPS 4. The percentage of patients with serum phosphorus level above 5.5 mg/dL was 57.4% in HD patients and 47.4% in PD patients. Age, dialysis patterns and region of residency were independently associated with hyperphosphatemia.

Conclusions: Status of MBD is sub-optimal among Chinese patients receiving dialysis. The issue of hyperphosphatemia is prominent and needs further attention.

语种: 英语
项目资助者: The Roche Pharma
WOS记录号: WOS:000311686200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62585
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Jiangsu Prov Hosp, Div Renal, Nanjing, Jiangsu, Peoples R China
2.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100871, Peoples R China
3.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
4.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
5.Beijing Hosp, Dept Nephrol, Beijing, Peoples R China
6.Gen Hosp Peoples Liberat Army, Dept Nephrol, Beijing, Peoples R China
7.Hosp Peking Shenzhen, Div Renal, Shenzhen, Peoples R China
8.455th Hosp PLA, Dept Nephrol, Shanghai, Peoples R China
9.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100871, Peoples R China
10.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China
11.China Japan Friendship Hosp, Dept Nephrol, Beijing, Peoples R China
12.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Nephrol, Shanghai 200030, Peoples R China
13.Shanghai Jiao Tong Univ, Sch Med, Div Renal, Xinhua Hosp, Shanghai 200030, Peoples R China
14.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510275, Guangdong, Peoples R China
15.Capital Med Univ, Beijing Friendship Hosp, Dept Nephrol, Beijing, Peoples R China
16.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China
17.Capital Med Univ, Beijing Chaoyang Hosp, Dept Nephrol, Beijing, Peoples R China
18.Shanghai Jiao Tong Univ, Shanghai People Hosp S 1, Dept Nephrol, Shanghai 200030, Peoples R China
19.Fourth Mil Med Univ, Xijing Hosp, Dept Nephrol, Xian 710032, Peoples R China
20.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China
21.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Nephrol, Shanghai, Peoples R China
22.Shantou Cent Hosp, Dept Internal Med, Shantou, Peoples R China
23.Fujian Prov Hosp, Dept Nephrol, Fuzhou, Peoples R China
24.Sichuan Prov Peoples Hosp, Dept Nephrol, Chengdu, Peoples R China
25.Fudan Univ, Huashan Hosp, Dept Nephrol, Shanghai 200433, Peoples R China
26.Capital Med Univ, Xuanwu Hosp, Dept Nephrol, Beijing, Peoples R China
27.Guangdong Gen Hosp, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
28.So Med Univ, Nanfang Hosp, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
29.Second Mil Med Univ, Changzheng Hosp, Dept Nephrol, Shanghai, Peoples R China
30.Shandong Univ, Qianfoshan Hosp, Dept Nephrol, Jinan 250100, Peoples R China
31.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Div Renal, Shanghai 200030, Peoples R China
32.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
33.Peking Univ, Hosp 1, Div Nephrol, Beijing 100034, Peoples R China
34.Peking Univ, Hosp 1, Key Lab, Minist Hlth, Beijing 100034, Peoples R China

Recommended Citation:
Kong, Xianglei,Zhang, Luxia,Zhang, Ling,et al. Mineral and bone disorder in Chinese dialysis patients: a multicenter study[J]. BMC NEPHROLOGY,2012,13.
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