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cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats
Qin, Jing1; Zhang, Ruo-Xi2; Li, Jia-Li2; Wang, Jian-Xin1; Hou, Jia1; Yang, Xu1; Zhu, Wei-Li2; Shi, Jie2; Lu, Lin2
关键词cRGD liposomes Edaravone Cytokine Antidepressant Brain targeting drug delivery
刊名EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2014-07-16
DOI10.1016/j.ejps.2014.03.006
58页:63-71
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; School of Pharmacy, Fudan University &amp ; The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education, China ; Beijing Higher Education Young Elite Teacher Project ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; School of Pharmacy, Fudan University &amp ; The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education, China ; Beijing Higher Education Young Elite Teacher Project
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TRAUMATIC BRAIN-INJURY ; FREE-RADICAL SCAVENGER ; MAJOR DEPRESSION ; DRUG-DELIVERY ; IN-VITRO ; CONVERTING-ENZYME ; NERVOUS-SYSTEM ; THP-1 CELLS ; TNF-ALPHA ; C-FOS
英文摘要

The delayed onset of therapeutic outcomes is a major drawback of the current antidepressants. The blood-brain barrier is the most important bottleneck impeding drug transport into the brain. Therefore, development of novel antidepressant medications with rapid onset and sustained activity is urgent. RGD liposomes showed an excellent effect of brain-targeting drug delivery and increased the entering rate to the brain. In the present study, we prepared cyclic RGD liposomes loaded with edaravone (cRGD-ERLs) and evaluated the potential antidepressant-like effects of this drug delivery system in rats. The results showed single injection of cRGD-ERLs produced significant antidepressant-like effects in both forced swim and novelty suppressed feeding test. Moreover, acute cRGD-ERLs increased the expression of c-fos in the medial prefrontal cortex, suggesting that cRGD-ERLs could activate the neuronal function. Furthermore, cRGD-ERLs reversed the increase of lipopolysaccharides (LPS)-induced plasma cytokine IL-1 beta and IL-6, suggesting that normalization of cytokine level might be involved in the behavioral response of cRGD-ERLs. Finally, cRGD-ERLs prevented the increase of immobility induced by LPS in the forced swim test. Overall, the current data revealed a novel brain-target drug delivery system, which can be used to improve the therapeutic outcomes of antidepressants by increase of crossing rate to the brain. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
所属项目编号81102386 ; 81371489 ; 20110071120042 ; YETP0068
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; School of Pharmacy, Fudan University &amp ; The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education, China ; Beijing Higher Education Young Elite Teacher Project ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; School of Pharmacy, Fudan University &amp ; The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education, China ; Beijing Higher Education Young Elite Teacher Project
WOS记录号WOS:000336828800008
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62587
专题中国药物依赖性研究所
作者单位1.Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ, Shanghai 201203, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Qin, Jing,Zhang, Ruo-Xi,Li, Jia-Li,et al. cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2014,58:63-71.
APA Qin, Jing.,Zhang, Ruo-Xi.,Li, Jia-Li.,Wang, Jian-Xin.,Hou, Jia.,...&Lu, Lin.(2014).cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,58,63-71.
MLA Qin, Jing,et al."cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 58(2014):63-71.
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