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学科主题: 药物依赖
题名:
cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats
作者: Qin, Jing1; Zhang, Ruo-Xi2; Li, Jia-Li2; Wang, Jian-Xin1; Hou, Jia1; Yang, Xu1; Zhu, Wei-Li2; Shi, Jie2; Lu, Lin2
关键词: cRGD liposomes ; Edaravone ; Cytokine ; Antidepressant ; Brain targeting drug delivery
刊名: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
发表日期: 2014-07-16
DOI: 10.1016/j.ejps.2014.03.006
卷: 58, 页:63-71
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TRAUMATIC BRAIN-INJURY ; FREE-RADICAL SCAVENGER ; MAJOR DEPRESSION ; DRUG-DELIVERY ; IN-VITRO ; CONVERTING-ENZYME ; NERVOUS-SYSTEM ; THP-1 CELLS ; TNF-ALPHA ; C-FOS
英文摘要:

The delayed onset of therapeutic outcomes is a major drawback of the current antidepressants. The blood-brain barrier is the most important bottleneck impeding drug transport into the brain. Therefore, development of novel antidepressant medications with rapid onset and sustained activity is urgent. RGD liposomes showed an excellent effect of brain-targeting drug delivery and increased the entering rate to the brain. In the present study, we prepared cyclic RGD liposomes loaded with edaravone (cRGD-ERLs) and evaluated the potential antidepressant-like effects of this drug delivery system in rats. The results showed single injection of cRGD-ERLs produced significant antidepressant-like effects in both forced swim and novelty suppressed feeding test. Moreover, acute cRGD-ERLs increased the expression of c-fos in the medial prefrontal cortex, suggesting that cRGD-ERLs could activate the neuronal function. Furthermore, cRGD-ERLs reversed the increase of lipopolysaccharides (LPS)-induced plasma cytokine IL-1 beta and IL-6, suggesting that normalization of cytokine level might be involved in the behavioral response of cRGD-ERLs. Finally, cRGD-ERLs prevented the increase of immobility induced by LPS in the forced swim test. Overall, the current data revealed a novel brain-target drug delivery system, which can be used to improve the therapeutic outcomes of antidepressants by increase of crossing rate to the brain. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81102386 ; 81371489 ; 20110071120042 ; YETP0068
项目资助者: National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; School of Pharmacy, Fudan University &amp ; The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education, China ; Beijing Higher Education Young Elite Teacher Project
WOS记录号: WOS:000336828800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62587
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ, Shanghai 201203, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Qin, Jing,Zhang, Ruo-Xi,Li, Jia-Li,et al. cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2014,58:63-71.
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