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学科主题临床医学
Regional variation among vacA alleles of Helicobacter pylori in China
Wang, JT; van Doorn, LJ; Robinson, PA; Ji, XH; Wang, D; Wang, Y; Ge, LY; Telford, JL; Crabtree, JE
刊名JOURNAL OF CLINICAL MICROBIOLOGY
2003-05-01
DOI10.1128/JCM.41.5.1942.1945.2003
41期:5页:1942-1945
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
研究领域[WOS]Microbiology
关键词[WOS]VACUOLATING CYTOTOXIN ; PATHOGENICITY ISLAND ; CLINICAL-RELEVANCE ; GASTRIC-CANCER ; GENE ; CAGA ; STRAINS ; GENOTYPES ; PREVALENCE ; INFECTION
英文摘要

Allelic variation among Helicobacter pylori vacA occurs in the signal and middle region of the gene. The aim of the study was to investigate alleleic variation of vacA among H. pylori strains from three regional areas of China and the relationship between vacA alleles and PUD. DNA extracted from 88 clinical isolates of H. pylori was analyzed by type-specific PCR and reverse hybridization line probe assay (LiPA) to determine the genotype of vacA and presence of cagA. In 87 isolates, all of the vacA alleles could be classified as either type s1c or type s1a, and all could be classified as m1, m2a, or m2b. One strain could not be typed. In all, 41% of patients were infected with multiple vacA genotypes, with the highest level being observed in Shanghai (63%). In strains from Beijing, s1a was dominant; by contrast, s1c was dominant in Guangxi and Shanghai. The prevalence of m2b strains in Shanghai (63%) was significantly higher than that in Beijing (83%) or Guangxi (0%). Thirty of the 87 patients had peptic ulcers. However, there was no association between vacA genotype and PUD. This study demonstrates that there is significant geographic diversity of genotype of vacA within China. The absence of vacA s2 genotypes precluded analysis of an association of vacA s genotypes and clinical disease.

语种英语
WOS记录号WOS:000182934500022
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62588
专题北京大学第二临床医学院_消化科
作者单位1.Guangxi Univ Tradit Chinese Med, Hosp 1, Guangxi, Peoples R China
2.Delft Diagnost Lab, Delft, Netherlands
3.Stanford Univ, Sch Med, Dept Med, Stanford, CA USA
4.Chiron Vaccines, Siena, Italy
5.St James Univ Hosp, Mol Med Unit, Leeds LS9 7TF, W Yorkshire, England
6.Beijing Univ, Peoples Hosp, Dept Gastroenterol, Beijing, Peoples R China
7.Beijing Univ, Peoples Hosp, Dept Hepatol, Beijing, Peoples R China
8.Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai, Peoples R China
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Wang, JT,van Doorn, LJ,Robinson, PA,et al. Regional variation among vacA alleles of Helicobacter pylori in China[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2003,41(5):1942-1945.
APA Wang, JT.,van Doorn, LJ.,Robinson, PA.,Ji, XH.,Wang, D.,...&Crabtree, JE.(2003).Regional variation among vacA alleles of Helicobacter pylori in China.JOURNAL OF CLINICAL MICROBIOLOGY,41(5),1942-1945.
MLA Wang, JT,et al."Regional variation among vacA alleles of Helicobacter pylori in China".JOURNAL OF CLINICAL MICROBIOLOGY 41.5(2003):1942-1945.
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