北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma
作者: Gao, Shu-Bin1,2; Sun, Shi-Long3; Zheng, Qi-Lin1; Zhang, Li1,2; Zhu, Yuequan4; Jin, Guang-Hui1,2; Xue, Li-Xiang4
关键词: Hepatocellular carcinoma ; Polycomb ; H3K27 trimetylation ; SNP
刊名: AMERICAN JOURNAL OF CANCER RESEARCH
发表日期: 2015
卷: 5, 期:10, 页:2969-+
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SOMATIC MUTATIONS ; DNA METHYLATION ; EZH2 ; MENIN ; TRANSCRIPTION ; REPRESSION ; MICRORNAS ; PROTEINS ; ENHANCER ; BINDING
英文摘要:

Although the abnormal expression of Polycomb-group (PcG) proteins is closely associated with carcinogenesis and the clinicopathological features of hepatocellular carcinoma (HCC), the genetic mutation profile of PcG genes has not been well established. In this study of human HCC specimens, we firstly discovered a highly conserved mutation site, G553C, in the Polycomb Repressive Complex 2 (PRC2) gene enhancer of zeste homolog 2 (EZH2). This site also harbors a single nucleotide polymorphism (SNP), rs2302427, which plays an important antagonistic role in HCC. Kaplan-Meier survival curves showed that the tumor-free and overall survival of patients with EZH2 G553C were superior to those without the mutation. The G allele frequencies in patients and healthy subjects were 0.2% and 0.122%, respectively, with significant differences in distribution. The individuals carrying the GG and the GC genotypes at rs2302427 showed 3.083-fold and 1.827-fold higher risks of HCC, respectively, compared with individuals carrying the wild-type allele. Furthermore, Immunohistochemical staining revealed that the expression levels of CBX8 (in 53/123 samples) and BMI1 (in 60/130 samples) were markedly increased in human HCC specimens. Importantly, the overall and tumor-free survival rates were significantly reduced in the group of patients who simultaneously expressed PRC1 and PRC2. These results argue that a combination of PRC1 and PRC2 expression has a significant predictive/prognostic value for HCC patients. Taken together, our results indicate the abnormal expression and genetic mutation of PcG members are two independent events; cumulative genetic and epigenetic alterations act synergistically in liver carcinogenesis.

语种: 英语
所属项目编号: 81472020 ; 31071206 ; 91229111 ; 81272719
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000365990400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62591
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Coll Med, Dept Basic Med Sci, Xiamen 361102, Peoples R China
2.Xiamen Univ, Fujian Prov Key Lab Chron Liver Dis & Hepatocellu, Xiamen 361102, Peoples R China
3.Jilin Univ, Minist Hlth, Key Lab Radiobiol, Changchun 130021, Peoples R China
4.Peking Univ, Hosp 3, Dept Radiat Oncol, Med Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Gao, Shu-Bin,Sun, Shi-Long,Zheng, Qi-Lin,et al. Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2015,5(10):2969-+.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, Shu-Bin]'s Articles
[Sun, Shi-Long]'s Articles
[Zheng, Qi-Lin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, Shu-Bin]‘s Articles
[Sun, Shi-Long]‘s Articles
[Zheng, Qi-Lin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace