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ANCA-negative pauci-immune crescentic glomerulonephritis
Chen, Min; Kallenberg, Cees G. M.2; Zhao, Ming-Hui1
刊名NATURE REVIEWS NEPHROLOGY
2009-06-01
DOI10.1038/nrneph.2009.67
5期:6页:313-318
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; ANTIENDOTHELIAL CELL ANTIBODIES ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ENDOTHELIAL-CELLS ; RENAL VASCULITIS ; ANTIMYELOPEROXIDASE ANTIBODIES ; WEGENERS-GRANULOMATOSIS ; NEUTROPHIL RECRUITMENT ; ACTIVATION
英文摘要

Crescentic glomerulonephritis is a severe form of glomerular injury that is characterized by disruption of the glomerular basement membrane, cellular proliferation within Bowman space, and (often) fibrinoid necrosis. Pauci-immune crescentic glomerulonephritis, so called because it involves little or no glomerular immunoglobulin deposition, is one of the most common causes of rapidly progressive glomerulonephritis. in the majority of patients, pauci-immune crescentic glomerulonephritis is a manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. However, some patients with pauci-immune crescentic glomerulonephritis lack ANCAs. This review compares the prevalence, clinical manifestations, histopathology, and outcomes of ANCA-negative pauci-immune crescentic glomerulonephritis with those of ANCA-positive disease. we also discuss the possible pathogenesis of ANCA-negative pauci-immune crescentic glomerulonephritis, paying particular attention to the mechanisms and role of neutrophil activation.

语种英语
WOS记录号WOS:000266570000006
项目编号985-2-104-113
资助机构Chinese 985 project
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被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62594
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Univ Groningen, Dept Rheumatol & Clin Immunol, Univ Med Ctr Groningen, NL-9700 AB Groningen, Netherlands
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Chen, Min,Kallenberg, Cees G. M.,Zhao, Ming-Hui. ANCA-negative pauci-immune crescentic glomerulonephritis[J]. NATURE REVIEWS NEPHROLOGY,2009,5(6):313-318.
APA Chen, Min,Kallenberg, Cees G. M.,&Zhao, Ming-Hui.(2009).ANCA-negative pauci-immune crescentic glomerulonephritis.NATURE REVIEWS NEPHROLOGY,5(6),313-318.
MLA Chen, Min,et al."ANCA-negative pauci-immune crescentic glomerulonephritis".NATURE REVIEWS NEPHROLOGY 5.6(2009):313-318.
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