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学科主题: 临床医学
题名:
ANCA-negative pauci-immune crescentic glomerulonephritis
作者: Chen, Min; Kallenberg, Cees G. M.2; Zhao, Ming-Hui1
刊名: NATURE REVIEWS NEPHROLOGY
发表日期: 2009-06-01
DOI: 10.1038/nrneph.2009.67
卷: 5, 期:6, 页:313-318
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; ANTIENDOTHELIAL CELL ANTIBODIES ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ENDOTHELIAL-CELLS ; RENAL VASCULITIS ; ANTIMYELOPEROXIDASE ANTIBODIES ; WEGENERS-GRANULOMATOSIS ; NEUTROPHIL RECRUITMENT ; ACTIVATION
英文摘要:

Crescentic glomerulonephritis is a severe form of glomerular injury that is characterized by disruption of the glomerular basement membrane, cellular proliferation within Bowman space, and (often) fibrinoid necrosis. Pauci-immune crescentic glomerulonephritis, so called because it involves little or no glomerular immunoglobulin deposition, is one of the most common causes of rapidly progressive glomerulonephritis. in the majority of patients, pauci-immune crescentic glomerulonephritis is a manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. However, some patients with pauci-immune crescentic glomerulonephritis lack ANCAs. This review compares the prevalence, clinical manifestations, histopathology, and outcomes of ANCA-negative pauci-immune crescentic glomerulonephritis with those of ANCA-positive disease. we also discuss the possible pathogenesis of ANCA-negative pauci-immune crescentic glomerulonephritis, paying particular attention to the mechanisms and role of neutrophil activation.

语种: 英语
所属项目编号: 985-2-104-113
项目资助者: Chinese 985 project
WOS记录号: WOS:000266570000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62594
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Univ Groningen, Dept Rheumatol & Clin Immunol, Univ Med Ctr Groningen, NL-9700 AB Groningen, Netherlands

Recommended Citation:
Chen, Min,Kallenberg, Cees G. M.,Zhao, Ming-Hui. ANCA-negative pauci-immune crescentic glomerulonephritis[J]. NATURE REVIEWS NEPHROLOGY,2009,5(6):313-318.
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