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学科主题: 临床医学
题名:
Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions
作者: Ding, Shigang; Li, Chenggang; Lin, Sanren; Yang, Yu; Liu, Donghui; Han, Yajing; Zhang, Ying; Li, Lina; Zhou, Liya; Kumar, Shant
关键词: angiogenesis ; gastric carcinoma ; microvessel density ; CD105 ; CD34
刊名: HUMAN PATHOLOGY
发表日期: 2006-07-01
DOI: 10.1016/j.humpath.2006.02.006
卷: 37, 期:7, 页:861-866
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; CELL LUNG-CANCER ; MICROVASCULAR DENSITY ; TUMOR ANGIOGENESIS ; BREAST-CARCINOMA ; PLASMA-LEVELS ; ANTIBODY ; EXPRESSION ; ENDOGLIN ; METASTASIS
英文摘要:

Microvessel density (MVD) is regarded as a surrogate marker for angiogenesis and has been used for tumor prognosis. In this study, MVD was identified immunohistochemically by monoclonal antibodies against CD 105 and CD34 in the tissues representing gastric carcinoma. chronic gastritis, and hyperplastic-polyps, and the results were correlated with clinicopathologic features. The expression of CD105 in the microvessels within benign lesions was barely visible, and MVD was markedly lower than that determined by CD34. CD34 was strongly expressed in the microvessels within hyperplastic polyps and tissues with gastritis. In gastric carcinoma, CD 105 expression in microvessels was as high as the MVD, compared with benign lesions. CD105 stained well-formed mature and newly formed immature vessels within the cancer mass. Correlation analysis showed that MVD determined by CD 105 correlated with blood vessel invasion, distant metastasis, and formation of ascites. Survival analysis demonstrated an inverse correlation between MVD count and overall survival: patients with MVD counts of 32 or higher survived for a much shorter time than those with counts lower than 32. Multivariate analysis confirmed that MVD determined by CD105 was an independent prognostic factor for survival. Microvessel density determined by CD34 inversely correlated with overall survival, but it did not Correlate with other clinicopathologic parameters except formation of ascites. In conclusion, CD34 was universally expressed in blood vessels within benign and malignant tissues, whereas CD 105 expression,vas minimal in benign tissues but stronger in gastric carcinoma. These data suggest that both CD105 and CD34 could be used for quantification of angiogenesis, but preference should be given to CD105 in the evaluation of prognosis in gastric carcinoma. (c) 2006 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000238819300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62596
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100083, Peoples R China
2.Univ Manchester, Sch Med, Dept Pathol, Manchester M13 9PT, Lancs, England
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China

Recommended Citation:
Ding, Shigang,Li, Chenggang,Lin, Sanren,et al. Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions[J]. HUMAN PATHOLOGY,2006,37(7):861-866.
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