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学科主题基础医学
NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules
Shen, Qi; Zheng, Xingzheng; McNutt, Michael A.; Guang, Lizhao; Sun, Ying; Wang, Jiaochen; Gong, Yilei; Hou, Lin; Zhang, Bo
关键词Histone acetyltransferase Nucleolus Midbody Cytokinesis DNA damage
刊名EXPERIMENTAL CELL RESEARCH
2009-06-10
DOI10.1016/j.yexcr.2009.03.007
315期:10页:1653-1667
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]TRANSCRIPTIONAL ACTIVATION ; MITOTIC CHROMOSOMES ; CO-LOCALIZE ; NUCLEAR ; MITOSIS ; RELOCALIZATION ; CENTROSOMES ; DYNAMICS ; CANCER
英文摘要

The midbody is a structural organelle formed in late phase mitosis which is responsible for completion of cytokinesis. Although various kinds of proteins have been found to distribute or immigrate to this organelle, their functions have still not been completely worked out. In this study, we demonstrated that NAT10 (N-acetyltransferase 10, NAT10) is not only predominantly distributed in the nucleolus in interphase, but is also concentrated in the mitotic midbody during telophase. The domain in N-terminal residues 549-834 of NAT10 specifically mediated its subcellular localization. Treatment with genotoxic agents or irradiation increased concentration of NAT10 in both the nucleolus and midbody. Moreover, DNA damage induced increase of NAT10 in the midbody apparently accompanied by in situ elevation of the level of acetylated alpha-tubulin, suggesting that it plays a role in maintaining or enhancing stability of alpha-tubulin. The depletion of NAT10 induced defects in nucleolar assembly, cytokinesis and decreased acetylated alpha-tubulin, leading to G2/M cell cycle arrest or delay of mitotic exit. In addition, over-expression of NAT10 was found in a variety of soft tissue sarcomas, and correlated with tumor histological grading. These results indicate that NAT10 may play an important role in cell division through facilitating reformation of the nucleolus and midbody in the late phase of cell mitosis, and stabilization of microtubules. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000266281000003
项目编号30770830 ; 200800010060
资助机构National Natural Science Foundation of China ; Chinese Education Ministry
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62597
专题北京大学基础医学院_病理学系
北京大学基础医学院
北京大学临床肿瘤学院_VIP-Ⅱ
作者单位Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
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GB/T 7714
Shen, Qi,Zheng, Xingzheng,McNutt, Michael A.,et al. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules[J]. EXPERIMENTAL CELL RESEARCH,2009,315(10):1653-1667.
APA Shen, Qi.,Zheng, Xingzheng.,McNutt, Michael A..,Guang, Lizhao.,Sun, Ying.,...&Zhang, Bo.(2009).NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules.EXPERIMENTAL CELL RESEARCH,315(10),1653-1667.
MLA Shen, Qi,et al."NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules".EXPERIMENTAL CELL RESEARCH 315.10(2009):1653-1667.
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