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学科主题: 药学
题名:
Alkyl and phenolic glycosides from Saussurea stella
作者: Wang, Tian-Min1,2; Wang, Ru-Feng1,3; Chen, Hu-Biao4; Shang, Ming-Ying1; Cai, Shao-Qing1
关键词: Saussurea stella ; Asteraceae ; Alkyl glycoside ; Phenolic glycoside ; Anti-inflammatory activity
刊名: FITOTERAPIA
发表日期: 2013-07-01
DOI: 10.1016/j.fitnote.2013.03.027
卷: 88, 页:38-43
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CONSTITUENTS ; FLAVONOIDS ; MEDUSA ; CELLS ; ACIDS
英文摘要:

One alkyl glycoside, saussurostelloside A (1), two phenolic glycosides, saussurostellosides B1 (2) and B2 (3), and 27 known compounds, including eleven flavonoids, seven phenolics, six lignans, one neolignan, one phenethyl glucoside and one fatty acid, were isolated from an ethanol extract of Saussurea stella (Asteraceae). Their structures were elucidated by NMR, MS, UV, and IR spectroscopic analysis. Of the known compounds, (+)-medioresinol-di-O-beta-D-glucoside (7), picraquassioside C (10), and diosmetin-3′-O-beta-D-glucoside (27) were isolated from the Asteraceae family for the first time, while (+)-pinoresinol-di-O-beta-D-glucoside (6), di-O-methylcrenatin (11), protocatechuic acid (14), 1,5-di-O-caffeoylquinic acid (17), formononetin (28), and phenethyl glucoside (29) were isolated from the Saussurea genus for the first time. The anti-inflammatory activities of three new compounds (1-3), five lignans ((-)-arctiin (4), (+)-pinoresinol-4-O-beta-D-glucoside (5), (+)-pinoresinol-di-O-beta-d-glucoside (6), (+)-medioresinol-di-O-beta-D-glucoside (7) and (+)-syringaresinol-4-O-beta-D-glucoside (8)), one neolignan (picraquassioside C (10)), and one phenolic glycoside (di-O-methylcrenatin (11)) were evaluated by testing their inhibition of the release of beta-glucuronidase from PAF-stimulated neutrophils. Only compound 5 showed moderate inhibition of the release of beta-glucuronidase, with an inhibition ratio of 39.1%. (C) 2013 Published by Elsevier B.V.

语种: 英语
所属项目编号: 985-2-063-112 ; 985
项目资助者: Program for Changjiang Scholars ; Innovative Research Team in University of the Ministry of Education of China ; second Project of Peking University
WOS记录号: WOS:000321599600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62599
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China
3.Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100102, Peoples R China
4.Hong Kong Baptist Univ, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wang, Tian-Min,Wang, Ru-Feng,Chen, Hu-Biao,et al. Alkyl and phenolic glycosides from Saussurea stella[J]. FITOTERAPIA,2013,88:38-43.
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