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Alkyl and phenolic glycosides from Saussurea stella
Wang, Tian-Min1,2; Wang, Ru-Feng1,3; Chen, Hu-Biao4; Shang, Ming-Ying1; Cai, Shao-Qing1
关键词Saussurea stella Asteraceae Alkyl glycoside Phenolic glycoside Anti-inflammatory activity
刊名FITOTERAPIA
2013-07-01
DOI10.1016/j.fitnote.2013.03.027
88页:38-43
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CONSTITUENTS ; FLAVONOIDS ; MEDUSA ; CELLS ; ACIDS
英文摘要

One alkyl glycoside, saussurostelloside A (1), two phenolic glycosides, saussurostellosides B1 (2) and B2 (3), and 27 known compounds, including eleven flavonoids, seven phenolics, six lignans, one neolignan, one phenethyl glucoside and one fatty acid, were isolated from an ethanol extract of Saussurea stella (Asteraceae). Their structures were elucidated by NMR, MS, UV, and IR spectroscopic analysis. Of the known compounds, (+)-medioresinol-di-O-beta-D-glucoside (7), picraquassioside C (10), and diosmetin-3′-O-beta-D-glucoside (27) were isolated from the Asteraceae family for the first time, while (+)-pinoresinol-di-O-beta-D-glucoside (6), di-O-methylcrenatin (11), protocatechuic acid (14), 1,5-di-O-caffeoylquinic acid (17), formononetin (28), and phenethyl glucoside (29) were isolated from the Saussurea genus for the first time. The anti-inflammatory activities of three new compounds (1-3), five lignans ((-)-arctiin (4), (+)-pinoresinol-4-O-beta-D-glucoside (5), (+)-pinoresinol-di-O-beta-d-glucoside (6), (+)-medioresinol-di-O-beta-D-glucoside (7) and (+)-syringaresinol-4-O-beta-D-glucoside (8)), one neolignan (picraquassioside C (10)), and one phenolic glycoside (di-O-methylcrenatin (11)) were evaluated by testing their inhibition of the release of beta-glucuronidase from PAF-stimulated neutrophils. Only compound 5 showed moderate inhibition of the release of beta-glucuronidase, with an inhibition ratio of 39.1%. (C) 2013 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000321599600007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62599
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China
3.Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100102, Peoples R China
4.Hong Kong Baptist Univ, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Wang, Tian-Min,Wang, Ru-Feng,Chen, Hu-Biao,et al. Alkyl and phenolic glycosides from Saussurea stella[J]. FITOTERAPIA,2013,88:38-43.
APA Wang, Tian-Min,Wang, Ru-Feng,Chen, Hu-Biao,Shang, Ming-Ying,&Cai, Shao-Qing.(2013).Alkyl and phenolic glycosides from Saussurea stella.FITOTERAPIA,88,38-43.
MLA Wang, Tian-Min,et al."Alkyl and phenolic glycosides from Saussurea stella".FITOTERAPIA 88(2013):38-43.
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