IR@PKUHSC  > 北京大学药学院
学科主题药学
Embelin derivatives and their anticancer activity through microtubule disassembly
Xu, MJ; Cui, JR; Fu, HZ; Proksch, P; Lin, WH; Li, M
关键词Aegiceras corniculatum Aegicerataceae anticancer cell cycle microtubules apoptosis
刊名PLANTA MEDICA
2005-10-01
DOI10.1055/s-2005-871250
71期:10页:944-948
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]AEGICERAS-CORNICULATUM ; TUMOR-CELLS ; PLANT ; DYNAMICS ; ASSAY
英文摘要

Biological activities of the 1,4-benzoquinone derivatives 5-O-ethylembelin (1) and 5-O-methylembelin (2) were investigated. Both of them showed anti proliferative activity against a panel of human tumor cell lines upon comparison to normal marsupial kidney cells (PtK2). They arrested HL-60 cells in the G(0)/G(1) phase of the cell cycle in a dose- and time-dependent manner. In HeLa cells, exposure to 100 mu M of 1 or 2 for 6 h induced a complete disassembly of the microtubule network and an increased number of cells blocked in mitotic stages. Treatment with 10 mu M of 1 and 2 for 24 h induced apoptosis in HL-60 cells. This evidence suggests that both 1 and 2 are promising novel antimitotic and anticancer molecules targeting microtubular proteins.

语种英语
WOS记录号WOS:000233401400010
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62601
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Univ Dusseldorf, Inst Pharmaceut Biol, D-4000 Dusseldorf, Germany
Recommended Citation
GB/T 7714
Xu, MJ,Cui, JR,Fu, HZ,et al. Embelin derivatives and their anticancer activity through microtubule disassembly[J]. PLANTA MEDICA,2005,71(10):944-948.
APA Xu, MJ,Cui, JR,Fu, HZ,Proksch, P,Lin, WH,&Li, M.(2005).Embelin derivatives and their anticancer activity through microtubule disassembly.PLANTA MEDICA,71(10),944-948.
MLA Xu, MJ,et al."Embelin derivatives and their anticancer activity through microtubule disassembly".PLANTA MEDICA 71.10(2005):944-948.
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