北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Embelin derivatives and their anticancer activity through microtubule disassembly
作者: Xu, MJ; Cui, JR; Fu, HZ; Proksch, P; Lin, WH; Li, M
关键词: Aegiceras corniculatum ; Aegicerataceae ; anticancer ; cell cycle ; microtubules ; apoptosis
刊名: PLANTA MEDICA
发表日期: 2005-10-01
DOI: 10.1055/s-2005-871250
卷: 71, 期:10, 页:944-948
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: AEGICERAS-CORNICULATUM ; TUMOR-CELLS ; PLANT ; DYNAMICS ; ASSAY
英文摘要:

Biological activities of the 1,4-benzoquinone derivatives 5-O-ethylembelin (1) and 5-O-methylembelin (2) were investigated. Both of them showed anti proliferative activity against a panel of human tumor cell lines upon comparison to normal marsupial kidney cells (PtK2). They arrested HL-60 cells in the G(0)/G(1) phase of the cell cycle in a dose- and time-dependent manner. In HeLa cells, exposure to 100 mu M of 1 or 2 for 6 h induced a complete disassembly of the microtubule network and an increased number of cells blocked in mitotic stages. Treatment with 10 mu M of 1 and 2 for 24 h induced apoptosis in HL-60 cells. This evidence suggests that both 1 and 2 are promising novel antimitotic and anticancer molecules targeting microtubular proteins.

语种: 英语
WOS记录号: WOS:000233401400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62601
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Univ Dusseldorf, Inst Pharmaceut Biol, D-4000 Dusseldorf, Germany

Recommended Citation:
Xu, MJ,Cui, JR,Fu, HZ,et al. Embelin derivatives and their anticancer activity through microtubule disassembly[J]. PLANTA MEDICA,2005,71(10):944-948.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, MJ]'s Articles
[Cui, JR]'s Articles
[Fu, HZ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, MJ]‘s Articles
[Cui, JR]‘s Articles
[Fu, HZ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace