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学科主题: 药学
题名:
Embelin derivatives and their anticancer activity through microtubule disassembly
作者: Xu, MJ; Cui, JR; Fu, HZ; Proksch, P; Lin, WH; Li, M
关键词: Aegiceras corniculatum ; Aegicerataceae ; anticancer ; cell cycle ; microtubules ; apoptosis
刊名: PLANTA MEDICA
发表日期: 2005-10-01
DOI: 10.1055/s-2005-871250
卷: 71, 期:10, 页:944-948
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: AEGICERAS-CORNICULATUM ; TUMOR-CELLS ; PLANT ; DYNAMICS ; ASSAY
英文摘要:

Biological activities of the 1,4-benzoquinone derivatives 5-O-ethylembelin (1) and 5-O-methylembelin (2) were investigated. Both of them showed anti proliferative activity against a panel of human tumor cell lines upon comparison to normal marsupial kidney cells (PtK2). They arrested HL-60 cells in the G(0)/G(1) phase of the cell cycle in a dose- and time-dependent manner. In HeLa cells, exposure to 100 mu M of 1 or 2 for 6 h induced a complete disassembly of the microtubule network and an increased number of cells blocked in mitotic stages. Treatment with 10 mu M of 1 and 2 for 24 h induced apoptosis in HL-60 cells. This evidence suggests that both 1 and 2 are promising novel antimitotic and anticancer molecules targeting microtubular proteins.

语种: 英语
WOS记录号: WOS:000233401400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62601
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Univ Dusseldorf, Inst Pharmaceut Biol, D-4000 Dusseldorf, Germany

Recommended Citation:
Xu, MJ,Cui, JR,Fu, HZ,et al. Embelin derivatives and their anticancer activity through microtubule disassembly[J]. PLANTA MEDICA,2005,71(10):944-948.
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