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学科主题: 临床医学
题名:
The Association between Atherosclerotic Renal Artery Stenosis and Acute Kidney Injury in Patients Undergoing Cardiac Surgery
作者: Yang, Jingang1,2; Lu, Changlin3; Yan, Li4; Tang, Xinran1,2; Li, Wei1,2; Yang, Yuejin1,2; Hu, Dayi5
刊名: PLOS ONE
发表日期: 2013-05-21
DOI: 10.1371/journal.pone.0064104
卷: 8, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MULTICENTERED RANDOMIZED-TRIAL ; X INTRAAORTIC FILTER ; OFF-PUMP ; ASCENDING AORTA ; BYPASS SURGERY ; CARDIOPULMONARY BYPASS ; CARDIOVASCULAR-DISEASE ; RENOVASCULAR DISEASE ; SURGICAL-PATIENTS ; RISK-FACTORS
英文摘要:

Background: Atherosclerotic renal artery stenosis (ARAS) and coronary artery disease (CAD) commonly co-exist. Some patients with unidentified ARAS may undergo cardiac surgery. While acute kidney injury (AKI) is a frequent and serious complication of cardiac surgery, we aim to evaluate the influence of ARAS on the occurrence of postoperative AKI in patients with normal or near-normal baseline renal function following cardiac surgery.

Methods: A total of 212 consecutive patients undergoing aortography after coronary angiography and cardiac surgery were retrospectively studied for their preoperative and intraoperative conditions. AKI was defined as an absolute increase in serum creatinine of more than or equal to 0.3 mg/dl (>= 26.4 mu mol/l) or a percentage increase in creatinine of more than or equal to 50% (1.5-fold from baseline) after cardiac surgery. A propensity score-adjusted logistic regression models was used in estimating the effect of ARAS on the risk of postoperative AKI.

Results: ARAS (>= 50%) was observed in 50 (23.6%) patients, and 83 (39.2%) developed AKI after cardiac surgery. A correlation existed between renal artery patency and preoperative-to-postoperative %Delta Cr in patients with ARAS (r = 0.297, P<0.0001). The propensity score-adjusted regression model showed the occurrence of postoperative AKI in patients with ARAS was significantly higher than those without ARAS (OR 2.858, 95% CI 1.260-6.480, P = 0.011).

Conclusion: ARAS is associated with postoperative AKI in patients with normal or near-normal baseline renal function after cardiac surgery.

语种: 英语
所属项目编号: 2006B52
项目资助者: Beijing Nova Program
WOS记录号: WOS:000319330200116
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62606
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Ctr Cardiovasc, Beijing, Peoples R China
4.Hebei Gen Hosp, Dept Cardiol, Shijiazhuang, Hebei Province, Peoples R China
5.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Jingang,Lu, Changlin,Yan, Li,et al. The Association between Atherosclerotic Renal Artery Stenosis and Acute Kidney Injury in Patients Undergoing Cardiac Surgery[J]. PLOS ONE,2013,8(5).
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