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Association analyses identify six new psoriasis susceptibility loci in the Chinese population
Sun, Liang-Dan1,2,3,4; Cheng, Hui1,2,3,4; Wang, Zai-Xing1,2,3,4; Zhang, An-Ping1,2,3,4; Wang, Pei-Guang1,2,3,4; Xu, Jin-Hua5; Zhu, Qi-Xing1,2,3,4; Zhou, Hai-Sheng4,6; Ellinghaus, Eva7; Zhang, Fu-Ren3,8; Pu, Xiong-Ming3,9; Yang, Xue-Qin3,10; Zhang, Jian-Zhong11; Xu, Ai-E3,12; Wu, Ri-Na13; Xu, Li-Min14; Peng, Lin15; Helms, Cynthia A.15; Ren, Yun-Qing1,2,3,4; Zhang, Chi1,2,3,4; Zhang, Shu-Mei1,2,4; Nair, Rajan P.16; Wang, Hong-Yan1,2,3,4; Lin, Guo-Shu1,2,3,4; Stuart, Philip E.16; Fan, Xing1,2,3,4; Chen, Gang3,4; Tejasvi, Trilokraj16; Li, Pan1,2,3,4; Zhu, Jun1,2,3,4; Li, Zhi-Ming1,2,3,4; Ge, Hong-Mei1,2,3,4; Weichenthal, Michael17; Ye, Wen-Zheng1,2,3,4; Zhang, Cheng1,2,3,4; Shen, Song-Ke1,2,3,4; Yang, Bao-Qi8; Sun, Yuan-Yuan1,2,3,4; Li, Shan-Shan1,2,3,4; Lin, Yan1,2,3,4; Jiang, Jian-Hua9; Li, Cun-Tao1,2,3,4; Chen, Ri-Xin1,2,3,4; Cheng, Juan10; Jiang, Xin1,2,3,4; Zhang, Peng1,2,3,4; Song, Wei-Min12; Tang, Jin1,2,3,4; Zhang, Hao-Qin1,2,3,4; Sun, Li; Cui, Jing1,2,3,4; Zhang, Li-Jun1,2,3,4; Tang, Biao1,2,3,4; Huang, Fei1,2,3,4; Qin, Qian1,2,3,4; Pei, Xiao-Ping1,2,3,4; Zhou, Ai-Min14; Shao, Li-Mei1,2,3,4; Liu, Jian-Lan1,2,3,4; Zhang, Feng-Yu1,2,4; Du, Wei-Dong1,2,4; Franke, Andre7; Bowcock, Anne M.15; Elder, James T.16; Liu, Jian-Jun1,2,4,18; Yang, Sen1,2,3,4; Zhang, Xue-Jun1,2,3,4,5
刊名NATURE GENETICS
2010-11-01
DOI10.1038/ng.690
42期:11页:1005-U132
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
资助者High-Tech Research and Development Program of China ; Natural Science Foundation of China ; US National Institutes of Health (NIH) ; German Ministry of Education ; National Genome Research Network ; National Psoriasis Foundation of the US ; Agency for Science, Technology and Research of Singapore ; High-Tech Research and Development Program of China ; Natural Science Foundation of China ; US National Institutes of Health (NIH) ; German Ministry of Education ; National Genome Research Network ; National Psoriasis Foundation of the US ; Agency for Science, Technology and Research of Singapore
研究领域[WOS]Genetics & Heredity
关键词[WOS]GENOME-WIDE ASSOCIATION ; ENDOTHELIAL GROWTH-FACTOR ; ANKYLOSING-SPONDYLITIS ; COMMON VARIANTS ; GENE-CLUSTER ; EXPRESSION ; IDENTIFICATION ; METAANALYSIS ; DISEASES ; PATHWAYS
英文摘要

We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 x 10(-8)) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 x 10(-21)) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 x 10(-3) and P = 7.9 x 10(-3), respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 x 10(-3) and P = 1.5 x 10(-3), respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.

语种英语
所属项目编号2007AA02Z161 ; 30530670 ; 30771196 ; 30771942 ; 30800990 ; 81072461 ; 81071285 ; 30972727 ; 30800610 ; 81000691 ; R01AR050266 ; R01AR42742 ; R01AR054966 ; R01AR050511 ; BMFT 01GS 0171 ; BMBF NUW-S23T10
资助者High-Tech Research and Development Program of China ; Natural Science Foundation of China ; US National Institutes of Health (NIH) ; German Ministry of Education ; National Genome Research Network ; National Psoriasis Foundation of the US ; Agency for Science, Technology and Research of Singapore ; High-Tech Research and Development Program of China ; Natural Science Foundation of China ; US National Institutes of Health (NIH) ; German Ministry of Education ; National Genome Research Network ; National Psoriasis Foundation of the US ; Agency for Science, Technology and Research of Singapore
WOS记录号WOS:000283540500020
引用统计
被引频次:167[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62610
专题北京大学第二临床医学院_皮科
作者单位1.Third Peoples Hosp Hangzhou, Hangzhou, Zhejiang, Peoples R China
2.Univ Hosp Schleswig Holstein, Dept Dermatol, Kiel, Germany
3.Genome Inst Singapore, Singapore, Singapore
4.Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
5.Gen Hosp Air Force, Dept Dermatol, Beijing, Peoples R China
6.Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei, Anhui, Peoples R China
7.Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei, Anhui, Peoples R China
8.Anhui Med Univ, Dept Dermatol & Venereol, Hefei, Anhui, Peoples R China
9.Minist Natl Sci & Technol, State Key Lab Incubat Base Dermatol, Hefei, Anhui, Peoples R China
10.Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
11.Anhui Med Univ, Dept Biochem & Mol Biol, Hefei, Anhui, Peoples R China
12.Shandong Prov Inst Dermatol & Venereol, Jinan, Shandong, Peoples R China
13.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Dermatol, Urumqi, Xinjiang, Peoples R China
14.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100871, Peoples R China
15.Affiliated Hosp, Inner Mongolia Med Coll, Dept Dermatol, Hohhot, Inner Mongolia, Peoples R China
16.Changzheng Hosp, Dept Dermatol, Tianjin, Peoples R China
17.Washington Univ, Sch Med, Div Human Genet, St Louis, MO USA
18.Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Sun, Liang-Dan,Cheng, Hui,Wang, Zai-Xing,et al. Association analyses identify six new psoriasis susceptibility loci in the Chinese population[J]. NATURE GENETICS,2010,42(11):1005-U132.
APA Sun, Liang-Dan.,Cheng, Hui.,Wang, Zai-Xing.,Zhang, An-Ping.,Wang, Pei-Guang.,...&Zhang, Xue-Jun.(2010).Association analyses identify six new psoriasis susceptibility loci in the Chinese population.NATURE GENETICS,42(11),1005-U132.
MLA Sun, Liang-Dan,et al."Association analyses identify six new psoriasis susceptibility loci in the Chinese population".NATURE GENETICS 42.11(2010):1005-U132.
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