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Microstructural White Matter Abnormalities Independent of White Matter Lesion Burden in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease Among Han Chinese Elderly
Liao, Jing1; Zhu, Yue2,3; Zhang, Meiyan2,3; Yuan, Huishu1; Su, Min-Ying4; Yu, Xin2,3; Wang, Huali2,3
关键词diffusion tensor imaging Alzheimer&prime s disease mild cognitive impairment parietal lobe
刊名ALZHEIMER DISEASE & ASSOCIATED DISORDERS
2010-10-01
DOI10.1097/WAD.0b013e3181df1c7b
24期:4页:317-324
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Pathology
研究领域[WOS]Neurosciences & Neurology ; Pathology
关键词[WOS]DIFFUSION-TENSOR ; STRUCTURAL INTEGRITY ; TEMPORAL-LOBE ; IN-VIVO ; DAMAGE ; DEMENTIA ; DEGENERATION ; HIPPOCAMPAL ; BREAKDOWN ; VOLUMES
英文摘要

This study was designed to evaluate the microstructural integrity of white matter (WM) in amnestic mild cognitive impairment (MCI) and Alzheimer′s disease (AD) among Han Chinese elderly using diffusion tensor imaging (DTI) technique, and to investigate the relationship between WM abnormalities and cognitive dysfunction. Sixty-four subjects (23 mild probable AD, 20 amnestic MCI, and 21 age-matched normal controls) who did not have visible WM lesion burden were analyzed. Fractional anisotropy (FA) and mean diffusivity were measured in normal-appearing WM (NAWM) using DTI with 64 encoding directions. The results were correlated with the scores of Mini-Mental State Examination (MMSE) and Cognitive Ability Screening Instrument (CASI). Statistical analysis showed the FA value in parietal WM was significantly lower in MCI compared to NC (P < 0.001), and further decreased in AD compared to MCI (P=0.005). The lower FA and elevated mean diffusivity values were found in temporal WM, frontal WM, parahippocampal and posterior cingulate fibers of AD group compared to MCI and NC (all P < 0.01). Canonical correlation analysis showed that the parietal FA values measured from all subjects were significantly correlated with the scores of CASI and MMSE (P < 0.01). The results indicated that DTI can detect microstructural WM abnormalities in AD and amnestic MCI, and the measures were correlated with cognitive performance. In MCI, the abnormality was found to be limited within the parietal WM; and in AD a more widespread alteration was found in other brain regions as well.

语种英语
WOS记录号WOS:000284308100002
项目编号30500178 ; 2003BA 712A11-03 ; 2007 AA02Z421
资助机构Natural Science Foundation of China ; National Key Project ; National Key RD 863 Project
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62616
专题北京大学第三临床医学院_放射科
北京大学精神卫生研究所_精神科
作者单位1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Peking Univ, Inst Mental Hlth, Dementia Care & Res Ctr, Beijing 100191, Peoples R China
4.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Irvine, CA USA
推荐引用方式
GB/T 7714
Liao, Jing,Zhu, Yue,Zhang, Meiyan,et al. Microstructural White Matter Abnormalities Independent of White Matter Lesion Burden in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease Among Han Chinese Elderly[J]. ALZHEIMER DISEASE &amp; ASSOCIATED DISORDERS,2010,24(4):317-324.
APA Liao, Jing.,Zhu, Yue.,Zhang, Meiyan.,Yuan, Huishu.,Su, Min-Ying.,...&Wang, Huali.(2010).Microstructural White Matter Abnormalities Independent of White Matter Lesion Burden in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease Among Han Chinese Elderly.ALZHEIMER DISEASE & ASSOCIATED DISORDERS,24(4),317-324.
MLA Liao, Jing,et al."Microstructural White Matter Abnormalities Independent of White Matter Lesion Burden in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease Among Han Chinese Elderly".ALZHEIMER DISEASE & ASSOCIATED DISORDERS 24.4(2010):317-324.
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