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学科主题: 临床医学
题名:
Microstructural White Matter Abnormalities Independent of White Matter Lesion Burden in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease Among Han Chinese Elderly
作者: Liao, Jing1; Zhu, Yue2,3; Zhang, Meiyan2,3; Yuan, Huishu1; Su, Min-Ying4; Yu, Xin2,3; Wang, Huali2,3
关键词: diffusion tensor imaging ; Alzheimer&prime ; s disease ; mild cognitive impairment ; parietal lobe
刊名: ALZHEIMER DISEASE & ASSOCIATED DISORDERS
发表日期: 2010-10-01
DOI: 10.1097/WAD.0b013e3181df1c7b
卷: 24, 期:4, 页:317-324
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Pathology
研究领域[WOS]: Neurosciences & Neurology ; Pathology
关键词[WOS]: DIFFUSION-TENSOR ; STRUCTURAL INTEGRITY ; TEMPORAL-LOBE ; IN-VIVO ; DAMAGE ; DEMENTIA ; DEGENERATION ; HIPPOCAMPAL ; BREAKDOWN ; VOLUMES
英文摘要:

This study was designed to evaluate the microstructural integrity of white matter (WM) in amnestic mild cognitive impairment (MCI) and Alzheimer′s disease (AD) among Han Chinese elderly using diffusion tensor imaging (DTI) technique, and to investigate the relationship between WM abnormalities and cognitive dysfunction. Sixty-four subjects (23 mild probable AD, 20 amnestic MCI, and 21 age-matched normal controls) who did not have visible WM lesion burden were analyzed. Fractional anisotropy (FA) and mean diffusivity were measured in normal-appearing WM (NAWM) using DTI with 64 encoding directions. The results were correlated with the scores of Mini-Mental State Examination (MMSE) and Cognitive Ability Screening Instrument (CASI). Statistical analysis showed the FA value in parietal WM was significantly lower in MCI compared to NC (P < 0.001), and further decreased in AD compared to MCI (P=0.005). The lower FA and elevated mean diffusivity values were found in temporal WM, frontal WM, parahippocampal and posterior cingulate fibers of AD group compared to MCI and NC (all P < 0.01). Canonical correlation analysis showed that the parietal FA values measured from all subjects were significantly correlated with the scores of CASI and MMSE (P < 0.01). The results indicated that DTI can detect microstructural WM abnormalities in AD and amnestic MCI, and the measures were correlated with cognitive performance. In MCI, the abnormality was found to be limited within the parietal WM; and in AD a more widespread alteration was found in other brain regions as well.

语种: 英语
所属项目编号: 30500178 ; 2003BA 712A11-03 ; 2007 AA02Z421
项目资助者: Natural Science Foundation of China ; National Key Project ; National Key RD 863 Project
WOS记录号: WOS:000284308100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62616
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Peking Univ, Inst Mental Hlth, Dementia Care & Res Ctr, Beijing 100191, Peoples R China
4.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Irvine, CA USA

Recommended Citation:
Liao, Jing,Zhu, Yue,Zhang, Meiyan,et al. Microstructural White Matter Abnormalities Independent of White Matter Lesion Burden in Amnestic Mild Cognitive Impairment and Early Alzheimer Disease Among Han Chinese Elderly[J]. ALZHEIMER DISEASE &amp; ASSOCIATED DISORDERS,2010,24(4):317-324.
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