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学科主题临床医学
DIFFERENTIAL DIAGNOSIS OF GALLBLADDER WALL THICKENING: THE USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND
Xu, Jun-Mei1; Guo, Le-Hang1; Xu, Hui-Xiong1,2; Zheng, Shu-Guang1,2; Liu, Lin-Na1,2; Sun, Li-Ping1; Lu, Ming-De2; Xie, Xiao-Yan2; Wang, Wen-Ping3; Hu, Bing4; Yan, Kun5; Ding, Hong3; Tang, Shao-Shan6; Qian, Lin-Xue7; Luo, Bao-Ming8
关键词Gallbladder Wall thickening Contrast-enhanced ultrasound Differential diagnosis Chronic cholecystitis Gallbladder carcinoma
刊名ULTRASOUND IN MEDICINE AND BIOLOGY
2014-12-01
DOI10.1016/j.ultrasmedbio.2014.06.015
40期:12页:2794-2804
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]XANTHOGRANULOMATOUS CHOLECYSTITIS ; ULTRASONOGRAPHY ; DISEASE ; CANCER ; BENIGN ; CARCINOMA ; US ; ADENOMYOMATOSIS ; SONOGRAPHY ; FEATURES
英文摘要

The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of gallbladder wall (GBW) thickening and determine the predictors of malignant GBW thickening. One hundred fifty-nine patients with GBW thickening, including 76 men and 83 women, from eight institutions were enrolled. CEUS was performed after injection of a sulfur hexafluoride microbubble-based ultrasound contrast agent. Multiple logistic regression analysis was used to reveal independent predictors associated with malignant GBW thickening. The final diagnoses were 48 gallbladder carcinomas and 111 benign gallbladder diseases. Maximal thicknesses of the GBW in malignant and benign GBW thickening were 17.3 +/- 5.2 (6-30) mm and 8.6 +/- 5.1 (4-26) mm respectively (p < 0.001). CEUS revealed significant differences in intralesional vessels, enhancement homogeneity, time to hypo-enhancement, inner layer discontinuity, outer layer discontinuity and adjacent liver involvement (all p-values < 0.05) between malignant and benign GBW thickening. Patient age > 46.5 y, focal GBW thickening, inner layer discontinuity and outer layer discontinuity were found to be associated with malignancy by multiple logistic regression analysis (all p-values < 0.05). Receiver operating characteristic curve analysis revealed Az values for patient age, focal GBW thickening, inner wall discontinuity and outer wall discontinuity of 0.709 (95% confidence interval [CI]: 0.627-0.790), 0.714 (95% CI: 0.630-0.798), 0.860 (95% CI: 0.791-0.928) and 0.858 (95% CI: 0.783-0.933), respectively. CEUS is useful in the differential diagnosis between malignant and benign GBW thickening. Focal GBW thickening, inner wall discontinuity and outer wall discontinuity observed on CEUS are diagnostic clues for malignant GBW thickening. (C) 2014 World Federation for Ultrasound in Medicine & Biology.

语种英语
WOS记录号WOS:000345623400006
项目编号20114003 ; 2013SY066 ; 81301299 ; 2012045
资助机构Shanghai Health and Family Planning Commission ; National Natural Scientific Foundation of China ; Shanghai Talent Development Project from the Shanghai Human Resource and Social Security Bureau
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62617
专题北京大学临床肿瘤学院_超声科
作者单位1.Tongji Univ, Shanghai Peoples Hosp 10, Dept Med Ultrasound, Shanghai 200072, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Ultrason, Guangzhou 510275, Guangdong, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Dept Ultrasound, Shanghai 200433, Peoples R China
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Ultrasound Med, Shanghai 200030, Peoples R China
5.Peking Univ, Sch Oncol, Beijing Canc Inst, Dept Ultrasound, Beijing 100871, Peoples R China
6.China Med Univ, Shengjing Hosp, Dept Ultrasound, Shenyang, Peoples R China
7.Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, Beijing, Peoples R China
8.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Ultrasound, Guangzhou 510275, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Xu, Jun-Mei,Guo, Le-Hang,Xu, Hui-Xiong,et al. DIFFERENTIAL DIAGNOSIS OF GALLBLADDER WALL THICKENING: THE USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2014,40(12):2794-2804.
APA Xu, Jun-Mei.,Guo, Le-Hang.,Xu, Hui-Xiong.,Zheng, Shu-Guang.,Liu, Lin-Na.,...&Luo, Bao-Ming.(2014).DIFFERENTIAL DIAGNOSIS OF GALLBLADDER WALL THICKENING: THE USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND.ULTRASOUND IN MEDICINE AND BIOLOGY,40(12),2794-2804.
MLA Xu, Jun-Mei,et al."DIFFERENTIAL DIAGNOSIS OF GALLBLADDER WALL THICKENING: THE USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND".ULTRASOUND IN MEDICINE AND BIOLOGY 40.12(2014):2794-2804.
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