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学科主题: 医学信息学
题名:
A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis
作者: Zhu, Yong1,2; Wang, Dongsheng3; Wang, Fang1,2; Li, Tingting4; Dong, Lei1,2; Liu, Huiwen1,2; Ma, Yanni1,2; Jiang, Fengbing1,2; Yin, Haixin1,2; Yan, Wenting1,2; Luo, Min1,2; Tang, Zhong3; Zhang, Guoyuan3; Wang, Qiang5; Zhang, Junwu1,2; Zhou, Jingguo3; Yu, Jia1,2
刊名: NUCLEIC ACIDS RESEARCH
发表日期: 2013-04-01
DOI: 10.1093/nar/gkt093
卷: 41, 期:7, 页:4129-4143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CELL-CYCLE REGULATION ; ERYTHROID-DIFFERENTIATION ; TRANSCRIPTION FACTORS ; CARDIAC-HYPERTROPHY ; MICRORNA EXPRESSION ; GENE-EXPRESSION ; STEM-CELLS ; ACTIVATION ; ZEBRAFISH ; GROWTH
英文摘要:

miRNAs play important roles in many biological processes, including erythropoiesis. Although several miRNAs regulate erythroid differentiation, how the key erythroid regulator, GATA-1, directly orchestrates differentiation through miRNA pathways remains unclear. In this study, we identified miR-23a as a key regulator of erythropoiesis, which was upregulated both during erythroid differentiation and in GATA-1 gain-of-function experiments, as determined by miRNA expression profile analysis. In primary human CD34+ hematopoietic progenitor cells, miR-23a increased in a GATA-1-dependent manner during erythroid differentiation. Gain- or loss-of-function analysis of miR-23a in mice or zebrafish demonstrated that it was essential for normal morphology in terminally differentiated erythroid cells. Furthermore, a protein tyrosine phosphatase, SHP2, was identified as a downstream target of miR-23a that mediated its regulation of erythropoiesis. Taken together, our data identify a key GATA-1-miRNA axis in erythroid differentiation.

语种: 英语
所属项目编号: 31040021 ; 31150002 ; 60905014 ; 81271643 ; 2011CBA01100 ; 2009RC03 ; 2010PYB06 ; 2010B071
项目资助者: National Natural Science Foundation of China ; National Key Basic Research Program of China ; IBMS, CAMS ; Beijing Municipal Science & ; Technology Commission
WOS记录号: WOS:000318167900031
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62620
Appears in Collections:基础医学院_医学信息学系_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biochem, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
2.Peking Union Med Coll, Beijing 100005, Peoples R China
3.North Sichuan Med Coll, Affiliated Hosp, Dept Lab Med, Nanchong 637000, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100191, Peoples R China
5.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China

Recommended Citation:
Zhu, Yong,Wang, Dongsheng,Wang, Fang,et al. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis[J]. NUCLEIC ACIDS RESEARCH,2013,41(7):4129-4143.
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