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学科主题医学信息学
A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis
Zhu, Yong1,2; Wang, Dongsheng3; Wang, Fang1,2; Li, Tingting4; Dong, Lei1,2; Liu, Huiwen1,2; Ma, Yanni1,2; Jiang, Fengbing1,2; Yin, Haixin1,2; Yan, Wenting1,2; Luo, Min1,2; Tang, Zhong3; Zhang, Guoyuan3; Wang, Qiang5; Zhang, Junwu1,2; Zhou, Jingguo3; Yu, Jia1,2
刊名NUCLEIC ACIDS RESEARCH
2013-04-01
DOI10.1093/nar/gkt093
41期:7页:4129-4143
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]CELL-CYCLE REGULATION ; ERYTHROID-DIFFERENTIATION ; TRANSCRIPTION FACTORS ; CARDIAC-HYPERTROPHY ; MICRORNA EXPRESSION ; GENE-EXPRESSION ; STEM-CELLS ; ACTIVATION ; ZEBRAFISH ; GROWTH
英文摘要

miRNAs play important roles in many biological processes, including erythropoiesis. Although several miRNAs regulate erythroid differentiation, how the key erythroid regulator, GATA-1, directly orchestrates differentiation through miRNA pathways remains unclear. In this study, we identified miR-23a as a key regulator of erythropoiesis, which was upregulated both during erythroid differentiation and in GATA-1 gain-of-function experiments, as determined by miRNA expression profile analysis. In primary human CD34+ hematopoietic progenitor cells, miR-23a increased in a GATA-1-dependent manner during erythroid differentiation. Gain- or loss-of-function analysis of miR-23a in mice or zebrafish demonstrated that it was essential for normal morphology in terminally differentiated erythroid cells. Furthermore, a protein tyrosine phosphatase, SHP2, was identified as a downstream target of miR-23a that mediated its regulation of erythropoiesis. Taken together, our data identify a key GATA-1-miRNA axis in erythroid differentiation.

语种英语
WOS记录号WOS:000318167900031
项目编号31040021 ; 31150002 ; 60905014 ; 81271643 ; 2011CBA01100 ; 2009RC03 ; 2010PYB06 ; 2010B071
资助机构National Natural Science Foundation of China ; National Key Basic Research Program of China ; IBMS, CAMS ; Beijing Municipal Science & ; Technology Commission
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被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62620
专题北京大学基础医学院_医学信息学系
北京大学基础医学院
作者单位1.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biochem, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
2.Peking Union Med Coll, Beijing 100005, Peoples R China
3.North Sichuan Med Coll, Affiliated Hosp, Dept Lab Med, Nanchong 637000, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100191, Peoples R China
5.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
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Zhu, Yong,Wang, Dongsheng,Wang, Fang,et al. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis[J]. NUCLEIC ACIDS RESEARCH,2013,41(7):4129-4143.
APA Zhu, Yong.,Wang, Dongsheng.,Wang, Fang.,Li, Tingting.,Dong, Lei.,...&Yu, Jia.(2013).A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis.NUCLEIC ACIDS RESEARCH,41(7),4129-4143.
MLA Zhu, Yong,et al."A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis".NUCLEIC ACIDS RESEARCH 41.7(2013):4129-4143.
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