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学科主题: 临床医学
题名:
Predictive factors for worse pathological outcomes of upper tract urothelial carcinoma: experience from a nationwide high-volume centre in China
作者: Chen, Xiao-Peng1; Xiong, Geng-Yan1; Li, Xue-Song1; Matin, Surena F.2; Garcia, Maurice3; Fang, Dong1; Wang, Tian-Yu1; Yu, Wei1; Gong, Kan1; Song, Yi1; He, Zhi-Song1; He, Qun1; Zhou, Li-Qun1
关键词: urothelial carcinoma ; upper urinary tract carcinoma ; worse pathological outcome ; non-organ-confined disease
刊名: BJU INTERNATIONAL
发表日期: 2013-11-01
DOI: 10.1111/bju.12238
卷: 112, 期:7, 页:917-924
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: TRANSITIONAL-CELL CARCINOMA ; UPPER URINARY-TRACT ; CHRONIC KIDNEY-DISEASE ; LYMPH-NODE DISSECTION ; RADICAL NEPHROURETERECTOMY ; ARISTOLOCHIC ACID ; HERBAL PRODUCTS ; CANCER ; IMPACT ; PROGNOSIS
英文摘要:

Objectives

To analyse the predictive factors for worse pathological outcome (muscle invasive pT2+, non-organ-confined pT3+ or N+ and histological Grade 3) of upper tract urothelial carcinoma (UTUC) in a Chinese population from a nationwide high-volume centre in China.

Patients and Methods

Predictors were studied by retrospectively reviewing the clinicopathological data of 729 consecutive patients with UTUC treated in our centre from January 2002 to December 2010.

Univariate and multivariate logistic regression analyses were used.

Results

There were more female patients (56.4%) than males and more tumours were located in the ureter (52.7%) than in the pelvis.

In multivariate analysis, male gender (hazard ratio [HR] 1.898, P = 0.001), sessile architecture (HR 3.249, P < 0.001), high grade (HR 5.007, P < 0.001), ipsilateral hydronephrosis (HR 4.768, P < 0.001), renal pelvis location (HR 2.620, P < 0.001) and tumour without multifocality (HR 1.639, P = 0.028) were predictive factors for muscle-invasive UTUC.

Male gender (HR 2.132, P < 0.001), renal pelvis location (HR 3.466, P < 0.001), tumour without multifocality (HR 2.532, P = 0.001), sessile tumour architecture (HR 3.274, P < 0.001), and high grade (HR 3.019, P < 0.001) were predictive factors for non-organ-confined disease.

Chronological old age (HR 1.047, P < 0.001), sessile tumour architecture (HR 25.192, P < 0.001), ipsilateral hydronephrosis (HR 1.689, P = 0.024), and positive urinary cytology (HR 1.997, P = 0.006) were predictive factors for histological Grade 3 UTUC.

Conclusions

There was a predominance of female patients and ureteric tumours in UTUCs of this Chinese population.

Male gender, sessile architecture, tumour location, tumour without multifocality, high histological grade and preoperative ipsilateral hydronephrosis were independent predictive factors for worse pathological outcome of UTUCs.

语种: 英语
WOS记录号: WOS:000325556600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62621
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Natl Urol Canc Ctr, Hosp 1, Dept Urol,Inst Urol, Beijing 100034, Peoples R China
2.Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA
3.Univ Calif San Francisco, Dept Urol, San Francisco, CA USA

Recommended Citation:
Chen, Xiao-Peng,Xiong, Geng-Yan,Li, Xue-Song,et al. Predictive factors for worse pathological outcomes of upper tract urothelial carcinoma: experience from a nationwide high-volume centre in China[J]. BJU INTERNATIONAL,2013,112(7):917-924.
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