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学科主题临床医学
Advances in the Genetics of Anti-Glomerular Basement Membrane Disease
Zhou, Xu-Jie; Lv, Ji-Cheng; Zhao, Ming-Hui; Zhang, Hong
关键词Anti-glomerular basement membrane disease HLA-DRB1*1501 FCGR KLK
刊名AMERICAN JOURNAL OF NEPHROLOGY
2010
DOI10.1159/000321324
32期:5页:482-490
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]COPY NUMBER VARIATION ; ANTI-GBM DISEASE ; EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; FC-GAMMA RECEPTORS ; GOODPASTURES-DISEASE ; LUPUS NEPHRITIS ; T-CELLS ; LINKAGE-DISEQUILIBRIUM ; NEPHROTOXIC NEPHRITIS
英文摘要

Anti-glomerular basement membrane (GBM) disease is a rare but lethal autoimmune disorder. Over the past few years, the nature of the autoantigen and its epitopes has been defined, as well as the possible pathogenic role played by environmental factors, and by cellular and humoral immunity. However, the majority of data on anti-GBM disease comes from studies conducted on animal models, since human studies are relatively scarce. Genetic studies have highlighted strong positive associations of anti-GBM disease with the HLA-DRB1*1501 allele. In addition, the disease has been associated with genes of the FCGR and KLK families. Important as they are, these findings have to be considered preliminary, if not contentious. Here, we provide an overview of recent discoveries in the genetics of anti-GBM disease that may help elucidate the disease pathogenesis while improving therapeutic approaches. We also discuss the limitations of such discoveries. Finally, we suggest that extensive collaboration between investigators and novel integrative approaches are essential to the progress of our understanding of the anti-GBM disease. We attempted to summarize the current knowledge on the pathogenesis of anti-GBM disease by providing different but complementary perspectives from previous reviews. Copyright (C) 2010 S. Karger AG, Basel

语种英语
WOS记录号WOS:000284282900013
项目编号30801022 ; 30825021 ; 200802052
资助机构National Natural Science Foundation of China ; Foundation of Ministry of Health of China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62626
专题北京大学第一临床医学院_肾脏内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Div Renal, Dept Med, Inst Nephrol,Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Xu-Jie,Lv, Ji-Cheng,Zhao, Ming-Hui,et al. Advances in the Genetics of Anti-Glomerular Basement Membrane Disease[J]. AMERICAN JOURNAL OF NEPHROLOGY,2010,32(5):482-490.
APA Zhou, Xu-Jie,Lv, Ji-Cheng,Zhao, Ming-Hui,&Zhang, Hong.(2010).Advances in the Genetics of Anti-Glomerular Basement Membrane Disease.AMERICAN JOURNAL OF NEPHROLOGY,32(5),482-490.
MLA Zhou, Xu-Jie,et al."Advances in the Genetics of Anti-Glomerular Basement Membrane Disease".AMERICAN JOURNAL OF NEPHROLOGY 32.5(2010):482-490.
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