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学科主题: 临床医学
题名:
Advances in the Genetics of Anti-Glomerular Basement Membrane Disease
作者: Zhou, Xu-Jie; Lv, Ji-Cheng; Zhao, Ming-Hui; Zhang, Hong
关键词: Anti-glomerular basement membrane disease ; HLA-DRB1*1501 ; FCGR ; KLK
刊名: AMERICAN JOURNAL OF NEPHROLOGY
发表日期: 2010
DOI: 10.1159/000321324
卷: 32, 期:5, 页:482-490
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: COPY NUMBER VARIATION ; ANTI-GBM DISEASE ; EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; FC-GAMMA RECEPTORS ; GOODPASTURES-DISEASE ; LUPUS NEPHRITIS ; T-CELLS ; LINKAGE-DISEQUILIBRIUM ; NEPHROTOXIC NEPHRITIS
英文摘要:

Anti-glomerular basement membrane (GBM) disease is a rare but lethal autoimmune disorder. Over the past few years, the nature of the autoantigen and its epitopes has been defined, as well as the possible pathogenic role played by environmental factors, and by cellular and humoral immunity. However, the majority of data on anti-GBM disease comes from studies conducted on animal models, since human studies are relatively scarce. Genetic studies have highlighted strong positive associations of anti-GBM disease with the HLA-DRB1*1501 allele. In addition, the disease has been associated with genes of the FCGR and KLK families. Important as they are, these findings have to be considered preliminary, if not contentious. Here, we provide an overview of recent discoveries in the genetics of anti-GBM disease that may help elucidate the disease pathogenesis while improving therapeutic approaches. We also discuss the limitations of such discoveries. Finally, we suggest that extensive collaboration between investigators and novel integrative approaches are essential to the progress of our understanding of the anti-GBM disease. We attempted to summarize the current knowledge on the pathogenesis of anti-GBM disease by providing different but complementary perspectives from previous reviews. Copyright (C) 2010 S. Karger AG, Basel

语种: 英语
所属项目编号: 30801022 ; 30825021 ; 200802052
项目资助者: National Natural Science Foundation of China ; Foundation of Ministry of Health of China
WOS记录号: WOS:000284282900013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62626
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Div Renal, Dept Med, Inst Nephrol,Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, Xu-Jie,Lv, Ji-Cheng,Zhao, Ming-Hui,et al. Advances in the Genetics of Anti-Glomerular Basement Membrane Disease[J]. AMERICAN JOURNAL OF NEPHROLOGY,2010,32(5):482-490.
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