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学科主题: 药学
题名:
Effects of Fluroquinolones in Newly Diagnosed, Sputum-Positive Tuberculosis Therapy: A Systematic Review and Network Meta-Analysis
作者: Li, Dandan1; Wang, Tiansheng2; Shen, Su1; Cheng, Sheng1; Yu, Junxian1; Zhang, Yang1; Zhang, Chao1; Tang, Huilin3
刊名: PLOS ONE
发表日期: 2015-12-15
DOI: 10.1371/journal.pone.0145066
卷: 10, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MULTIDRUG-RESISTANT TUBERCULOSIS ; RANDOMIZED CONTROLLED-TRIALS ; EARLY BACTERICIDAL ACTIVITY ; PULMONARY TUBERCULOSIS ; MYCOBACTERIUM-TUBERCULOSIS ; STERILIZING ACTIVITIES ; CULTURE CONVERSION ; CONTAINING REGIMEN ; PHASE-II ; MOXIFLOXACIN
英文摘要:

Background

Tuberculosis is a major public health problem especially in developing countries, the comparative efficacy and safety of fluroquinolones (FQs) for adult patients with newly diagnosed, sputum-positive tuberculosis remains controversial. We aimed to investigate the benefits and risks of FQs-containing (addition/substitution) regimens in this population.

Methods

A network meta-analysis was performed to compare FQs (C: ciprofloxacin; O: ofloxacin; Lo: levofloxacin; M: moxifloxacin; G: gatifloxacin) addition/substitution regimen with standard HRZE regimen (ie isoniazid, rifampicin, pyrazinamide and ethambutol) in newly diagnosed, sputum-positive tuberculosis. Medline, Embase and Cochrane Central Register of Controlled Trials were systematically searched, randomized trials with duration longer than 8 weeks were included. The primary outcome was week-8 sputum negativity, and secondary outcomes included treatment failure, serious adverse events and death from all cause.

Results

Twelve studies comprising 6465 participants were included in the network meta-analysis. Lowenstein-Jensen culture method showed that HRZEM (OR 4.96, 95% CI 2.83-8.67), MRZE (OR 1.48, 95% CI 1.19-1.84) and HRZM (OR 1.32, 95% CI 1.08-1.62) had more sputum conversion than HRZE by the eighth week, whereas HRC (OR 0.39, 95% CI 0.19-0.77) and HRZO (OR 0.47, 95% CI 0.24-0.92) were worse than HRZE. Moxifloxacin-containing regimens showed more conversion than HRZE by liquid method at the end of two months. But by the end of treatment, FQs-containing regimens didn′t show superiority than HRZE on treatment failure. There were no significant differences between any regimens on other outcomes like serious adverse events and all-cause death.

Conclusion

This comprehensive network meta-analysis showed that compared with HRZE, moxifloxacin-containing regimens could significantly increase sputum conversion by the eighth week for patients with newly diagnosed pulmonary tuberculosis while HRC and HRZO regimens were inferior. But all the FQs-containing regimens did not show superiority in other outcomes (such as treatment failure, serious adverse events and all-cause death). Thus, HRZE is still an effective regimen for this population. Although moxifloxacin-containing regimens have deomonstrated their potential, FQs-containing regimens should be used with great caution to avoid widespread FQs-resistance worldwide.

语种: 英语
WOS记录号: WOS:000366719300044
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62628
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Friendship Hosp, Dept Pharm, Beijing, Peoples R China
2.Peking Univ, Dept Pharm Adm & Clin Pharm, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
3.Peking Univ, Dept Pharm, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Li, Dandan,Wang, Tiansheng,Shen, Su,et al. Effects of Fluroquinolones in Newly Diagnosed, Sputum-Positive Tuberculosis Therapy: A Systematic Review and Network Meta-Analysis[J]. PLOS ONE,2015,10(12).
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