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学科主题口腔医学
The difficult relationship between occlusal interferences and temporomandibular disorder - insights from animal and human experimental studies
Xie, Q.; Li, X.; Xu, X.
关键词occlusion temporomandibular disorder animal human
刊名JOURNAL OF ORAL REHABILITATION
2013-04-01
DOI10.1111/joor.12034
40期:4页:279-295
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]MANDIBULAR CONDYLAR CARTILAGE ; TRIGEMINAL SUBNUCLEUS CAUDALIS ; UNILATERAL TOOTH LOSS ; DORSAL RAPHE NUCLEUS ; ASTROCYTES IN-SITU ; MASSETER MUSCLE ; SPINAL-CORD ; GLYCOSAMINOGLYCAN SYNTHESIS ; TOPOGRAPHIC ORGANIZATION ; PARABRACHIAL NUCLEUS
英文摘要

The aetiology of temporomandibular disorder (TMD) is multifactorial, and numerous studies have addressed that occlusion may be of great importance. However, whether occlusion plays a crucial role in the pathogenesis of TMD remains controversial. Study designs utilising animal models have been used to study the effects of artificial occlusal alterations. Experimental traumatic occlusion affects blood flow in the temporomandibular joint and results in changes in the condylar cartilage, and artificial occlusal interference induces masticatory muscle nociceptive responses that are associated with peripheral sensitisation and lead to central sensitisation, which maintains masticatory muscle hyperalgesia. The possibility that occlusal interference results in TMD has been investigated in humans using a double-blind randomised design. Subjects without a history of TMD show fairly good adaptation to interferences. In contrast, subjects with a history of TMD develop a significant increase in clinical signs and self-report stronger symptoms (occlusal discomfort and chewing difficulties) in response to interferences. Meanwhile, psychological factors appear meaningful for symptomatic responses to artificial interferences in subjects with a history of TMD. Thus, individual differences in vulnerability to occlusal interferences do exist. Although there are advantages and disadvantages to using human and animal occlusal interference models, these approaches are indispensable for discovering the role of occlusion in TMD pathogenesis.

语种英语
WOS记录号WOS:000316225600006
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62639
专题北京大学口腔医学院_口腔修复科
北京大学临床肿瘤学院_核医学科
作者单位Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 10081, Peoples R China
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GB/T 7714
Xie, Q.,Li, X.,Xu, X.. The difficult relationship between occlusal interferences and temporomandibular disorder - insights from animal and human experimental studies[J]. JOURNAL OF ORAL REHABILITATION,2013,40(4):279-295.
APA Xie, Q.,Li, X.,&Xu, X..(2013).The difficult relationship between occlusal interferences and temporomandibular disorder - insights from animal and human experimental studies.JOURNAL OF ORAL REHABILITATION,40(4),279-295.
MLA Xie, Q.,et al."The difficult relationship between occlusal interferences and temporomandibular disorder - insights from animal and human experimental studies".JOURNAL OF ORAL REHABILITATION 40.4(2013):279-295.
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