北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学医药卫生分析中心  > 期刊论文
学科主题: 公共卫生
题名:
Tc-99m-3PRGD(2) Scintimammography in Palpable and Nonpalpable Breast Lesions
作者: Liu, Lin; Song, Yan; Gao, Shi; Ji, Tiefeng; Zhang, Haishan; Ji, Bin; Chen, Ben; Jia, Bing; Wang, Fan; Xu, Zheli; Ma, Qingjie3
刊名: MOLECULAR IMAGING
发表日期: 2014-07-01
DOI: 10.2310/7290.2014.00010
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Biochemistry & Molecular Biology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: TECHNETIUM-99M-MIBI SCINTIMAMMOGRAPHY ; TC-99M SESTAMIBI ; CANCER ; DIAGNOSIS ; METAANALYSIS ; ANGIOGENESIS ; MAMMOGRAPHY ; CARCINOMA ; MORTALITY ; INTEGRIN
英文摘要:

The aim of this study was to explore the diagnostic performance of Tc-99m-3(poly-(ethylene glycol), PEG) 4-RGD(2) (Tc-99m-3PRGD(2)) scintimammography (SMM) in patients with either palpable or nonpalpable breast lesions and compare SMM to mammography to assess the possible incremental value of SMM in breast cancer detection. We also investigated the alpha(v)beta(3) expression in malignant and benign breast lesions. Ninety-four patients with 110 lesions were included in this study. Mammograms were evaluated according to the Breast Imaging Reporting and Data System (BI-RADS) by a specialized imaging radiologist. Prone SMM was performed 1 hour after injection of Tc-99m-3PRGD(2). Scintigraphic images were interpreted independently by two experienced nuclear medicine physicians using a three-point system, and the kappa value was calculated to determine the interreader agreement. The McNemar test was used to compare SMM and mammography with respect to sensitivity, specificity, and accuracy. Diagnostic values for breast cancer detection were evaluated for each lesion. Immunohistochemistry was performed to evaluate integrin avb3 expression. Histopathology revealed 46 malignant lesions and 64 benign lesions. The overall sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of SMM were 83%, 73%, 77%, 69%, and 85%, respectively. The kappa value between the two reviewers was 0.63. The diagnostic values of SMM were higher than those of mammography in evaluating overall breast lesions. A sensitivity of 91% was achieved when SMM and mammography results were combined with 60% of all false-negative mammography findings classified as true-positive results by SMM. Integrin avb3 expression was positively identified using SMM imaging. SMM is a promising tool to avoid unnecessary biopsies when used in addition to mammography and can be used to image avb3 expression in breast cancer with good image quality.

语种: 英语
所属项目编号: 81271606 ; 201015185 ; 201201041
项目资助者: National Natural Science Foundation of China (NSFC) ; Science and Technology Department of Jilin Province
WOS记录号: WOS:000344215600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62643
Appears in Collections:北京大学医药卫生分析中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Jilin Univ, China Japan Union Hosp, Dept Radiol, Changchun 130023, Peoples R China
2.Jilin Univ, China Japan Union Hosp, Dept Breast Surg, Changchun 130023, Peoples R China
3.Jilin Univ, China Japan Union Hosp, Dept Nucl Med, Changchun 130023, Peoples R China
4.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Lin,Song, Yan,Gao, Shi,et al. Tc-99m-3PRGD(2) Scintimammography in Palpable and Nonpalpable Breast Lesions[J]. MOLECULAR IMAGING,2014,13.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Lin]'s Articles
[Song, Yan]'s Articles
[Gao, Shi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Lin]‘s Articles
[Song, Yan]‘s Articles
[Gao, Shi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace