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学科主题: 临床医学
题名:
Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives
作者: Ding, Ning1; Zhang, Zaihong2; Zhang, Wei1; Chun, Yuexing2; Wang, Peng2; Qi, Huimin3; Wang, Shan3; Li, Yingxia1
关键词: Oligorhamnoside ; Antibacterial activities ; Cleistrioside ; Cleistetrosides ; Antibiotic-resistant
刊名: CARBOHYDRATE RESEARCH
发表日期: 2011-10-18
DOI: 10.1016/j.carres.2011.07.028
卷: 346, 期:14, 页:2126-2135
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: CLEISTOPHOLIS-GLAUCA ; NATURAL-PRODUCTS ; CHEMISTRY METHODS ; PATENS ; CLEISTETROSIDE-2 ; GLYCOSYLATION ; CLARHAMNOSIDE ; RECOGNITION ; CLATHRODES ; CAMPESTRIS
英文摘要:

A series of novel oligorhamnoside derivatives (1-10) and naturally occurring cleistrioside-5 were synthesized and evaluated for their in vitro antibacterial activities. Among them, dirhamnoside derivative 7 and cleistrioside-5 displayed similar antibacterial profiles and exhibited moderate to good inhibitory activities on bacterial growth against a panel of Gram-positive bacteria (MICs <= 4-32 mu g/mL). The results revealed that these two compounds showed selectivity towards bacterial species strictly, without being affected by the antibiotic-resistant/susceptible properties of one species, which suggested that they might have the potential to avoid antibiotic cross-resistance. In addition, the preliminary SARs of this type of oligorhamnoside derivatives on the antibacterial activities were determined. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 21002014 ; 20100071120051 ; 10FX061
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China (RFDP) ; Fundamental Research Funds for the Central Universities ; Startup Foundation for Young Teachers, School of Pharmacy, Fudan University
WOS记录号: WOS:000295754100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62645
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.Fudan Univ, Dept Med Chem, Sch Pharm, Shanghai 201203, Peoples R China
2.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
3.Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing, Peoples R China

Recommended Citation:
Ding, Ning,Zhang, Zaihong,Zhang, Wei,et al. Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives[J]. CARBOHYDRATE RESEARCH,2011,346(14):2126-2135.
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