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Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives
Ding, Ning1; Zhang, Zaihong2; Zhang, Wei1; Chun, Yuexing2; Wang, Peng2; Qi, Huimin3; Wang, Shan3; Li, Yingxia1
关键词Oligorhamnoside Antibacterial activities Cleistrioside Cleistetrosides Antibiotic-resistant
刊名CARBOHYDRATE RESEARCH
2011-10-18
DOI10.1016/j.carres.2011.07.028
346期:14页:2126-2135
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]CLEISTOPHOLIS-GLAUCA ; NATURAL-PRODUCTS ; CHEMISTRY METHODS ; PATENS ; CLEISTETROSIDE-2 ; GLYCOSYLATION ; CLARHAMNOSIDE ; RECOGNITION ; CLATHRODES ; CAMPESTRIS
英文摘要

A series of novel oligorhamnoside derivatives (1-10) and naturally occurring cleistrioside-5 were synthesized and evaluated for their in vitro antibacterial activities. Among them, dirhamnoside derivative 7 and cleistrioside-5 displayed similar antibacterial profiles and exhibited moderate to good inhibitory activities on bacterial growth against a panel of Gram-positive bacteria (MICs <= 4-32 mu g/mL). The results revealed that these two compounds showed selectivity towards bacterial species strictly, without being affected by the antibiotic-resistant/susceptible properties of one species, which suggested that they might have the potential to avoid antibiotic cross-resistance. In addition, the preliminary SARs of this type of oligorhamnoside derivatives on the antibacterial activities were determined. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000295754100010
项目编号21002014 ; 20100071120051 ; 10FX061
资助机构National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China (RFDP) ; Fundamental Research Funds for the Central Universities ; Startup Foundation for Young Teachers, School of Pharmacy, Fudan University
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62645
专题北京大学第一临床医学院_临床药理研究所
作者单位1.Fudan Univ, Dept Med Chem, Sch Pharm, Shanghai 201203, Peoples R China
2.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
3.Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing, Peoples R China
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GB/T 7714
Ding, Ning,Zhang, Zaihong,Zhang, Wei,et al. Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives[J]. CARBOHYDRATE RESEARCH,2011,346(14):2126-2135.
APA Ding, Ning.,Zhang, Zaihong.,Zhang, Wei.,Chun, Yuexing.,Wang, Peng.,...&Li, Yingxia.(2011).Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives.CARBOHYDRATE RESEARCH,346(14),2126-2135.
MLA Ding, Ning,et al."Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives".CARBOHYDRATE RESEARCH 346.14(2011):2126-2135.
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