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Initial Research on Fourier Transform Infrared Spectroscopy for the Diagnosis of Colon Neoplasms
Yao Hong-wei1; Liu Ya-qi1; Fu Wei1; Shi Xue-ying2; Zhang Yuan-fu3; Xu Yi-zhuang3
关键词Fourier transform infrared spectrometry Colon neoplasm Diagnosis
刊名SPECTROSCOPY AND SPECTRAL ANALYSIS
2011-02-01
DOI10.3964/j.issn.1000-0593(2011)02-0297-05
31期:2页:297-301
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Spectroscopy
研究领域[WOS]Spectroscopy
关键词[WOS]CANCER
英文摘要

To explore the feasibility of Fourier transform infrared spectrometry (FTIR) for the diagnosis of colon neoplasms, fresh samples of eighteen cancers and ten adenomas were collected during colon surgery and were measured by FTIR via probe of attenuated total reflection (ATR). The peak position and the intensity of all bands were measured and compared between the malignant and benign groups. Results show that the FTIR of malignant neoplasm was different from that of benign one. (1)For the bands related to lipid: The ratio of I(2) (925)/I(1) (460) (p=0.018) and I(1) (740)/I(1) (460) (P=0.009) decreased in cancer FTIR spectrum, indicating the lower relative quantity of lipid in malignant neoplasm. (2)For the bands related to protein: The ratios of I(3) (375)/I(1) (460) (p=0.012) and I(1) (550)/I(1) (460) (p=0.041) increased in cancer, which shows that the relative quantity of protein was more in cancer than that in adenoma. (3) For the band related to nucleic acid: In malignant tissue the peak position in 1 080 cm(-1) shifted toward a higher wave number (p=0.039), compared with that in benign one. And the ratio of I(1) (083)/I(1) (460) increased significantly (p=0.036), illustrating the higher relative quantity of nucleic acid to lipids in malignancy. (4) The peak position of 1 305 cm(-1) shifted to a lower wavenumber (p=0.041), which should be determined in further research. It is concluded that our initial research showed that the FTIR maybe develops into a promising method for rapid differential diagnosis of colon malignant and benign neoplasms.

语种中文
WOS记录号WOS:000287263400002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62647
专题北京大学第三临床医学院_普通外科
北京大学基础医学院
作者单位1.Peking Univ, Dept Gen Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
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Yao Hong-wei,Liu Ya-qi,Fu Wei,et al. Initial Research on Fourier Transform Infrared Spectroscopy for the Diagnosis of Colon Neoplasms[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2011,31(2):297-301.
APA Yao Hong-wei,Liu Ya-qi,Fu Wei,Shi Xue-ying,Zhang Yuan-fu,&Xu Yi-zhuang.(2011).Initial Research on Fourier Transform Infrared Spectroscopy for the Diagnosis of Colon Neoplasms.SPECTROSCOPY AND SPECTRAL ANALYSIS,31(2),297-301.
MLA Yao Hong-wei,et al."Initial Research on Fourier Transform Infrared Spectroscopy for the Diagnosis of Colon Neoplasms".SPECTROSCOPY AND SPECTRAL ANALYSIS 31.2(2011):297-301.
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