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学科主题: 临床医学
题名:
Initial Research on Fourier Transform Infrared Spectroscopy for the Diagnosis of Colon Neoplasms
作者: Yao Hong-wei1; Liu Ya-qi1; Fu Wei1; Shi Xue-ying2; Zhang Yuan-fu3; Xu Yi-zhuang3
关键词: Fourier transform infrared spectrometry ; Colon neoplasm ; Diagnosis
刊名: SPECTROSCOPY AND SPECTRAL ANALYSIS
发表日期: 2011-02-01
DOI: 10.3964/j.issn.1000-0593(2011)02-0297-05
卷: 31, 期:2, 页:297-301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: CANCER
英文摘要:

To explore the feasibility of Fourier transform infrared spectrometry (FTIR) for the diagnosis of colon neoplasms, fresh samples of eighteen cancers and ten adenomas were collected during colon surgery and were measured by FTIR via probe of attenuated total reflection (ATR). The peak position and the intensity of all bands were measured and compared between the malignant and benign groups. Results show that the FTIR of malignant neoplasm was different from that of benign one. (1)For the bands related to lipid: The ratio of I(2) (925)/I(1) (460) (p=0.018) and I(1) (740)/I(1) (460) (P=0.009) decreased in cancer FTIR spectrum, indicating the lower relative quantity of lipid in malignant neoplasm. (2)For the bands related to protein: The ratios of I(3) (375)/I(1) (460) (p=0.012) and I(1) (550)/I(1) (460) (p=0.041) increased in cancer, which shows that the relative quantity of protein was more in cancer than that in adenoma. (3) For the band related to nucleic acid: In malignant tissue the peak position in 1 080 cm(-1) shifted toward a higher wave number (p=0.039), compared with that in benign one. And the ratio of I(1) (083)/I(1) (460) increased significantly (p=0.036), illustrating the higher relative quantity of nucleic acid to lipids in malignancy. (4) The peak position of 1 305 cm(-1) shifted to a lower wavenumber (p=0.041), which should be determined in further research. It is concluded that our initial research showed that the FTIR maybe develops into a promising method for rapid differential diagnosis of colon malignant and benign neoplasms.

语种: 中文
WOS记录号: WOS:000287263400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62647
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Dept Gen Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Yao Hong-wei,Liu Ya-qi,Fu Wei,et al. Initial Research on Fourier Transform Infrared Spectroscopy for the Diagnosis of Colon Neoplasms[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2011,31(2):297-301.
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