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学科主题: 精神卫生
题名:
Regional quantification of white matter hyperintensity in normal aging, mild cognitive impairment, and Alzheimer′s disease
作者: Chen, Ya-Fang; Wang, Huali; Chu, Yong; Huang, Yung-Chien; Su, Min-Ying
关键词: Alzheimer&prime ; s disease ; brain aging ; cognitive tests ; magnetic resonance imaging ; mild cognitive impairment ; white matter lesions
刊名: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
发表日期: 2006
DOI: 10.1159/000094785
卷: 22, 期:2, 页:177-184
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology ; Clinical Neurology ; Psychiatry
研究领域[WOS]: Geriatrics & Gerontology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: ROTTERDAM-SCAN ; DEMENTIA ; MRI ; LESIONS ; ABNORMALITIES ; PEOPLE ; HEALTH ; BRAIN
英文摘要:

Background/Aims: A quantitative method was applied to measure the volume of white matter hyperintensity (WMH) in different brain regions of subjects with Alzheimer′s disease ( AD), mild cognitive impairment (MCI) and normal healthy age-matched controls, and the relationship between regional WMH and age and cognitive function was investigated. Methods: Fifty-six subjects were included in this study, 27 AD, 15 MCI and 14 normal age-matched controls. A user-friendly software was developed for WMH quantification in frontal, temporal, and parieto-occipital lobes. Mini-Mental State Examination and cognitive scores in performing naming, language fluency, and memory tasks were obtained for correlation analysis. Results: AD patients had the greatest total WMH volume, followed by MCI, then controls. However, there was a large variation within each group, and the difference did not reach a significant level. There was a positive linear correlation between the total WMH ( p = 0.031) and the frontal WMH ( p = 0.006) vs. age. After age correction the Boston Naming Test scores were negatively correlated with the total WMH volume in the AD ( p = 0.03) and the control ( p = 0.03) groups, and with the frontal WMH in controls ( p = 0.01). Conclusion: We demonstrated a quantitative analysis method to measure regional WMH. Although WMH was not strongly associated with disease severity or cognition, it may provide a characteristic neuroimaging parameter in the study of AD development. Copyright (C) 2006 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000242166900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62652
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Calif Irvine, Tu & Yuen Ctr Funct Oncoimaging, Irvine, CA 92697 USA
2.Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei, Taiwan
3.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China
4.Cathay Gen Hosp, Dept Radiol, Taipei, Taiwan

Recommended Citation:
Chen, Ya-Fang,Wang, Huali,Chu, Yong,et al. Regional quantification of white matter hyperintensity in normal aging, mild cognitive impairment, and Alzheimer′s disease[J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,2006,22(2):177-184.
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