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学科主题: 临床医学
题名:
Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
作者: Bachem, Max G.; Zhou, Zhengfei; Zhou, Shaoxia; Siech, Marco
关键词: chronic pancreatitis ; pancreas fibrosis ; pancreatic stellate cells
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2006-10-01
DOI: 10.1111/j.1440-1746.2006.04592.x
卷: suppl.3, 页:S92-S96
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: COLLAGEN TYPE-I ; ALCOHOLIC PANCREATITIS ; LIPID-PEROXIDATION ; MATRIX SYNTHESIS ; TISSUE-DAMAGE ; FIBROSIS ; IDENTIFICATION ; PROLIFERATION ; ACTIVATION ; MEDIATORS
英文摘要:

Pancreas fibrosis is the result of a dynamic cascade of mechanisms beginning with acinar cell (AC) injury and necrosis and followed by inflammation, activation of macrophages, aggregation of platelets, release of growth factors and reactive oxygen species (ROS), activation of pancreatic stellate cells (PSC), stimulated synthesis of extracellular matrix and reduced matrix degradation. The result is a net matrix accumulation. Numerous in vivo and in vitro studies have provided strong evidence of a central role for PSC in fibrogenesis associated with acute and chronic pancreatitis. The PSC share homologies with hepatic stellate cells (HSC). In normal pancreas, the fat-storing phenotype of PSC is found in low numbers (approx. 4% of the cells) in the periacinar and interlobular space. Similar to the stellate cell-activating mechanisms in the liver, in pancreas injury PSC change their phenotype from the fat-storing to a highly active matrix-producing cell type (activated PSC). The induction of the activated phenotype of PSC has been shown to involve a number of diverse extra- and intracellular effector molecules, including inflammatory cytokines, growth factors, ethanol, acetaldehyde, and oxidative stress.

语种: 英语
WOS记录号: WOS:000239919600024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62654
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: 1.Univ Hosp Ulm, Dept Clin Chem, D-89070 Ulm, Germany
2.Ostalb Klinikum Aalen, Dept Gen & Vasc Surg, Aalen, Germany
3.Beijing Univ, Hosp 1, Dept Gen Surg, Beijing, Peoples R China

Recommended Citation:
Bachem, Max G.,Zhou, Zhengfei,Zhou, Shaoxia,et al. Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2006,suppl.3:S92-S96.
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