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Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
Bachem, Max G.; Zhou, Zhengfei; Zhou, Shaoxia; Siech, Marco
关键词chronic pancreatitis pancreas fibrosis pancreatic stellate cells
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2006-10-01
DOI10.1111/j.1440-1746.2006.04592.x
suppl.3页:S92-S96
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]COLLAGEN TYPE-I ; ALCOHOLIC PANCREATITIS ; LIPID-PEROXIDATION ; MATRIX SYNTHESIS ; TISSUE-DAMAGE ; FIBROSIS ; IDENTIFICATION ; PROLIFERATION ; ACTIVATION ; MEDIATORS
英文摘要

Pancreas fibrosis is the result of a dynamic cascade of mechanisms beginning with acinar cell (AC) injury and necrosis and followed by inflammation, activation of macrophages, aggregation of platelets, release of growth factors and reactive oxygen species (ROS), activation of pancreatic stellate cells (PSC), stimulated synthesis of extracellular matrix and reduced matrix degradation. The result is a net matrix accumulation. Numerous in vivo and in vitro studies have provided strong evidence of a central role for PSC in fibrogenesis associated with acute and chronic pancreatitis. The PSC share homologies with hepatic stellate cells (HSC). In normal pancreas, the fat-storing phenotype of PSC is found in low numbers (approx. 4% of the cells) in the periacinar and interlobular space. Similar to the stellate cell-activating mechanisms in the liver, in pancreas injury PSC change their phenotype from the fat-storing to a highly active matrix-producing cell type (activated PSC). The induction of the activated phenotype of PSC has been shown to involve a number of diverse extra- and intracellular effector molecules, including inflammatory cytokines, growth factors, ethanol, acetaldehyde, and oxidative stress.

语种英语
WOS记录号WOS:000239919600024
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62654
专题北京大学第一临床医学院_普通外科
作者单位1.Univ Hosp Ulm, Dept Clin Chem, D-89070 Ulm, Germany
2.Ostalb Klinikum Aalen, Dept Gen & Vasc Surg, Aalen, Germany
3.Beijing Univ, Hosp 1, Dept Gen Surg, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Bachem, Max G.,Zhou, Zhengfei,Zhou, Shaoxia,et al. Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2006,suppl.3:S92-S96.
APA Bachem, Max G.,Zhou, Zhengfei,Zhou, Shaoxia,&Siech, Marco.(2006).Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,suppl.3,S92-S96.
MLA Bachem, Max G.,et al."Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY suppl.3(2006):S92-S96.
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