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学科主题: 临床医学
题名:
Extracellular signal-regulated protein kinase in human intractable epilepsy
作者: Xi, Z.-Q.; Wang, X.-F.; He, R.-Q.; Li, M.-W.; Liu, X.-Z.; Wang, L.-Y.; Zhu, X.; Xiao, F.; Sun, J.-J.; Li, J.-M.; Gong, Y.; Guan, L.-F.
关键词: epilepsy ; seizures ; extracellular signal-regulated protein kinase ; phosphorylation
刊名: EUROPEAN JOURNAL OF NEUROLOGY
发表日期: 2007-08-01
DOI: 10.1111/j.1468-1331.2007.01777.x
卷: 14, 期:8, 页:865-872
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: KAINATE-INDUCED SEIZURES ; TEMPORAL-LOBE EPILEPSY ; ERK MAP KINASE ; RAT HIPPOCAMPUS ; ACTIVATION ; BRAIN ; PHOSPHORYLATION ; EXPRESSION ; PATHWAYS ; INJURY
英文摘要:

Extracellular signal-regulated kinases (ERK) such as ERK1 [p44 mitogen-activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the central nervous system under physiological and pathological conditions such as ischemia and epilepsy. Our aim is to investigate ERK1, ERK2, and phosphorylated ERK (p-ERK) (Thr202/Tyr 204) expression in the temporal lobe of patients with intractable epilepsy (IE) and to explore its possible role of ERK in it. Tissue samples from temporal neocortices of 40 patients who had surgery for IE were used to detect ERK1, ERK2, and p-ERK (Thr 202/Tyr 204) expression through immunohistochemistry and western blot. We compared these tissues against 17 histological normal temporal lobes from head-traumat patients. ERK1, ERK2, and p-ERK in IE were significantly higher than those in the controls. They were mainly expressed in the cytoplasm of neurons and glial cells. There was also increased detection of p-ERK in the gliotic cortex of IE compared with the non-gliotic cortex. These findings were consistently observed in western blot and immunohistochemistry techniques. ERK expression in patients with IE was significantly increased compared with the controls. This suggested a probable role of ERK in the pathogenesis of IE.

语种: 英语
WOS记录号: WOS:000248598700020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62658
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
2.Chinese Acad Sci, Lab Visual Informat Proc, Beijing, Peoples R China
3.Biogenidec Inc, Cambridge, MA USA
4.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100871, Peoples R China
5.Peking Univ, Sch Publ Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Xi, Z.-Q.,Wang, X.-F.,He, R.-Q.,et al. Extracellular signal-regulated protein kinase in human intractable epilepsy[J]. EUROPEAN JOURNAL OF NEUROLOGY,2007,14(8):865-872.
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