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学科主题: 基础医学
题名:
Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis
作者: Zhao, Yaofeng; Pan-Hammarstrom, Qiang; Yu, Shuyang; Wertz, Nancy; Zhang, Xiaofeng; Li, Ning; Butler, John E.; Hammarstrom, Lennart
关键词: amphibians ; antibody evolution
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
发表日期: 2006-08-08
DOI: 10.1073/pnas.0600291103
卷: 103, 期:32, 页:12087-12092
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: IMMUNOGLOBULIN HEAVY-CHAIN ; CONSTANT-REGION ; MESSENGER-RNA ; EVOLUTIONARY ORIGIN ; NUCLEOTIDE-SEQUENCE ; CHANNEL CATFISH ; TELEOST FISH ; GENE LOCUS ; DELTA-GENE ; ISOTYPE
英文摘要:

Only three Ig isotypes, IgM, IgX, and IgY, were previously known in amphibians. Here, we describe a heavy-chain isotype in Xenopus tropicalis, IgF (encoded by C-phi), with only two constant region domains. IgF is similar to amphibian IgY in sequence, but the gene contains a hinge exon, making it the earliest example, in evolution, of an Ig isotype with a separately encoded genetic hinge. We also characterized a gene for the heavy chain of IgD, located immediately 3′ of C-mu, that shares features with the C-delta gene in fish and mammals. The latter gene contains eight constant-region-encoding exons and, unlike the chimeric splicing of mu C(H)1 onto the IgD heavy chain in teleost fish, it is expressed as a unique IgD heavy chain. The IgH locus of X. tropicalis shows a 5′ V-H-D-H-J(H)-C-mu-C-delta-C-chi- C-upsilon-C-phi 3′ organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor.

语种: 英语
WOS记录号: WOS:000239701900048
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62662
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
2.China Agr Univ, State Key Lab AgroBiotechnol, Beijing 100094, Peoples R China
3.Karolinska Univ Hosp, Karolinska Inst, Div Clin Immunol, SE-14186 Stockholm, Sweden
4.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China
5.Karolinska Inst, Ctr Struct Biochem, SE-14157 Stockholm, Sweden

Recommended Citation:
Zhao, Yaofeng,Pan-Hammarstrom, Qiang,Yu, Shuyang,et al. Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2006,103(32):12087-12092.
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