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Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue micro array immuno staining
Ma Ding; Yang Bing; Zhou Zhe; Pan Dongliang; Zhang Xianghua
关键词biomarkers risk factors benign prostatic hyperplasia clinical progression tissue microarray
刊名CHINESE MEDICAL JOURNAL
2014-12-05
DOI10.3760/cma.j.issn.0366-6999.20140711
127期:23页:4031-4035
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]EXPRESSION ; CANCER ; RECEPTOR ; CELLS ; BPH ; INFLAMMATION ; VEGF ; PATHOGENESIS ; DENSITY ; PROTEIN
英文摘要

Background The pathogenesis of benign prostatic hyperplasia (BPH) has been widely studied, and several biomarkers are known to play roles in its development. This study aimed to investigate the possible role of cysteine-rich protein 61 (CYR61), vascular endothelial growth factor (VEGF), androgen receptor (AR), interleukin-6 (IL-6), cytochrome c, caspase-3, and proliferating cell nuclear antigen (PCNA) in the clinical progression of BPH.

Methods Tissue specimens from 96 BPH cases who underwent transurethral resection of the prostate were processed and transferred to tissue microarrays. Patient age, prostate volume, serum prostate-specific antigen (PSA) level, and International Prostate Symptom Score (IPSS) of all BPH cases were collected before surgery. The expression of CYR61, VEGF, AR, IL-6, cytochrome c, caspase-3, and PCNA was examined by immunostaining in the BPH specimens, and any possible correlation between the different biomarkers and risk factors for BPH clinical progression was analyzed.

Results The expression of CYR61, VEGF, AR, IL-6, cytochrome c, caspase-3, and PCNA in the BPH cases was 68.8% (66/96), 77.1% (74/96), 43.8% (42/96), 31.3% (30/96), 35.4% (34/96), 56.3% (54/96), and 29.2% (28/96), respectively. The expression of both CYR61 and VEGF was positively correlated with patient age, prostate volume, and serum PSA level (P <0.05). Furthermore, cytochrome c and caspase-3 expression were inversely related to prostate volume (P <0.05), and AR expression was positively related to serum PSA level (P <0.05).

Conclusion CYR61 and VEGF expression might serve as biomarkers for predicting the clinical progression of BPH due to effects on stromal cell proliferation and angiogenesis.

语种英语
WOS记录号WOS:000347276500006
项目编号14020200557
资助机构Special Funds for Clinical Medicine Research Project of Chinese Medical Association
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62665
专题北京大学首钢医院_泌尿外科
北京大学第二临床医学院_肾内科
作者单位Peking Univ, Shougang Hosp, Dept Urol, Beijing 100144, Peoples R China
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GB/T 7714
Ma Ding,Yang Bing,Zhou Zhe,et al. Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue micro array immuno staining[J]. CHINESE MEDICAL JOURNAL,2014,127(23):4031-4035.
APA Ma Ding,Yang Bing,Zhou Zhe,Pan Dongliang,&Zhang Xianghua.(2014).Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue micro array immuno staining.CHINESE MEDICAL JOURNAL,127(23),4031-4035.
MLA Ma Ding,et al."Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue micro array immuno staining".CHINESE MEDICAL JOURNAL 127.23(2014):4031-4035.
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