北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学首钢医院  > 泌尿外科  > 期刊论文
学科主题: 临床医学
题名:
Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue micro array immuno staining
作者: Ma Ding; Yang Bing; Zhou Zhe; Pan Dongliang; Zhang Xianghua
关键词: biomarkers ; risk factors ; benign prostatic hyperplasia ; clinical progression ; tissue microarray
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-12-05
DOI: 10.3760/cma.j.issn.0366-6999.20140711
卷: 127, 期:23, 页:4031-4035
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: EXPRESSION ; CANCER ; RECEPTOR ; CELLS ; BPH ; INFLAMMATION ; VEGF ; PATHOGENESIS ; DENSITY ; PROTEIN
英文摘要:

Background The pathogenesis of benign prostatic hyperplasia (BPH) has been widely studied, and several biomarkers are known to play roles in its development. This study aimed to investigate the possible role of cysteine-rich protein 61 (CYR61), vascular endothelial growth factor (VEGF), androgen receptor (AR), interleukin-6 (IL-6), cytochrome c, caspase-3, and proliferating cell nuclear antigen (PCNA) in the clinical progression of BPH.

Methods Tissue specimens from 96 BPH cases who underwent transurethral resection of the prostate were processed and transferred to tissue microarrays. Patient age, prostate volume, serum prostate-specific antigen (PSA) level, and International Prostate Symptom Score (IPSS) of all BPH cases were collected before surgery. The expression of CYR61, VEGF, AR, IL-6, cytochrome c, caspase-3, and PCNA was examined by immunostaining in the BPH specimens, and any possible correlation between the different biomarkers and risk factors for BPH clinical progression was analyzed.

Results The expression of CYR61, VEGF, AR, IL-6, cytochrome c, caspase-3, and PCNA in the BPH cases was 68.8% (66/96), 77.1% (74/96), 43.8% (42/96), 31.3% (30/96), 35.4% (34/96), 56.3% (54/96), and 29.2% (28/96), respectively. The expression of both CYR61 and VEGF was positively correlated with patient age, prostate volume, and serum PSA level (P <0.05). Furthermore, cytochrome c and caspase-3 expression were inversely related to prostate volume (P <0.05), and AR expression was positively related to serum PSA level (P <0.05).

Conclusion CYR61 and VEGF expression might serve as biomarkers for predicting the clinical progression of BPH due to effects on stromal cell proliferation and angiogenesis.

语种: 英语
所属项目编号: 14020200557
项目资助者: Special Funds for Clinical Medicine Research Project of Chinese Medical Association
WOS记录号: WOS:000347276500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62665
Appears in Collections:北京大学首钢医院_泌尿外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Shougang Hosp, Dept Urol, Beijing 100144, Peoples R China

Recommended Citation:
Ma Ding,Yang Bing,Zhou Zhe,et al. Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue micro array immuno staining[J]. CHINESE MEDICAL JOURNAL,2014,127(23):4031-4035.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma Ding]'s Articles
[Yang Bing]'s Articles
[Zhou Zhe]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma Ding]‘s Articles
[Yang Bing]‘s Articles
[Zhou Zhe]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace