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学科主题: 公共卫生
题名:
Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro
作者: Kong, Dan; Xing, Lina; Liu, Ran; Jiang, Jianjun; Wang, Wanyi; Shang, Lanqin; Wei, Xuetao; Hao, Weidong
关键词: Bisphenol A ; Genistein ; Embronic stem cell test ; Embryotoxicity ; Combined effect
刊名: FOOD AND CHEMICAL TOXICOLOGY
发表日期: 2013-10-01
DOI: 10.1016/j.fct.2013.08.006
卷: 60, 页:497-505
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology ; Toxicology
研究领域[WOS]: Food Science & Technology ; Toxicology
关键词[WOS]: BREAST-CANCER RISK ; PHYTOESTROGEN GENISTEIN ; POSTMENOPAUSAL WOMEN ; PHYTO-ESTROGENS ; GENE-EXPRESSION ; BINARY-MIXTURES ; SOY ISOFLAVONE ; TEST EST ; EXPOSURE ; DIFFERENTIATION
英文摘要:

The potential developmental toxicity of environmental estrogenic endocrine disruptors have become a great concern in recent years. In this study, two typical environmental oestrogen, namely, bisphenol A (BPA) and genistein (GEN) were investigated for potential embryotoxicity using the embryonic stem cell test model. Afterwards, a 4 x 4 full factorial design and the estimated marginal means plot were performed to assess the combined effects of these two compounds.

According to the linear discriminant functions and classification criteria, bisphenol A and genistein were classified as weakly embryotoxic and strongly embryotoxic respectively. As for combined effects, the overall interaction between BPA and GEN on embryonic stem cells (ESCs) differentiation was synergistic at low dosages, however, on ESCs and 3T3 cell proliferation, the predominate action was additive. Considering the actual daily intake of these chemicals, it is concluded that BPA alone might not have adverse reproductive or developmental effects on human being. However, given that BPA and GEN do have synergistic effect at low concentration, they may disturb normal embryo development together, which could result in birth defect and behavioral alterations later in life. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30972501 ; 30771821 ; 2009 ZX 09301-010
项目资助者: National Science Foundation of the People&prime ; s Republic of China ; National Science and Technology Major Specific Project
WOS记录号: WOS:000325231700061
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62667
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Dept Toxicol, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Kong, Dan,Xing, Lina,Liu, Ran,et al. Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,60:497-505.
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