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Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro
Kong, Dan; Xing, Lina; Liu, Ran; Jiang, Jianjun; Wang, Wanyi; Shang, Lanqin; Wei, Xuetao; Hao, Weidong
关键词Bisphenol A Genistein Embronic stem cell test Embryotoxicity Combined effect
刊名FOOD AND CHEMICAL TOXICOLOGY
2013-10-01
DOI10.1016/j.fct.2013.08.006
60页:497-505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology ; Toxicology
资助者National Science Foundation of the People&prime ; s Republic of China ; National Science and Technology Major Specific Project ; National Science Foundation of the People&prime ; s Republic of China ; National Science and Technology Major Specific Project
研究领域[WOS]Food Science & Technology ; Toxicology
关键词[WOS]BREAST-CANCER RISK ; PHYTOESTROGEN GENISTEIN ; POSTMENOPAUSAL WOMEN ; PHYTO-ESTROGENS ; GENE-EXPRESSION ; BINARY-MIXTURES ; SOY ISOFLAVONE ; TEST EST ; EXPOSURE ; DIFFERENTIATION
英文摘要

The potential developmental toxicity of environmental estrogenic endocrine disruptors have become a great concern in recent years. In this study, two typical environmental oestrogen, namely, bisphenol A (BPA) and genistein (GEN) were investigated for potential embryotoxicity using the embryonic stem cell test model. Afterwards, a 4 x 4 full factorial design and the estimated marginal means plot were performed to assess the combined effects of these two compounds.

According to the linear discriminant functions and classification criteria, bisphenol A and genistein were classified as weakly embryotoxic and strongly embryotoxic respectively. As for combined effects, the overall interaction between BPA and GEN on embryonic stem cells (ESCs) differentiation was synergistic at low dosages, however, on ESCs and 3T3 cell proliferation, the predominate action was additive. Considering the actual daily intake of these chemicals, it is concluded that BPA alone might not have adverse reproductive or developmental effects on human being. However, given that BPA and GEN do have synergistic effect at low concentration, they may disturb normal embryo development together, which could result in birth defect and behavioral alterations later in life. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号30972501 ; 30771821 ; 2009 ZX 09301-010
资助者National Science Foundation of the People&prime ; s Republic of China ; National Science and Technology Major Specific Project ; National Science Foundation of the People&prime ; s Republic of China ; National Science and Technology Major Specific Project
WOS记录号WOS:000325231700061
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62667
专题北京大学公共卫生学院_毒理学系
作者单位Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Dept Toxicol, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Kong, Dan,Xing, Lina,Liu, Ran,et al. Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,60:497-505.
APA Kong, Dan.,Xing, Lina.,Liu, Ran.,Jiang, Jianjun.,Wang, Wanyi.,...&Hao, Weidong.(2013).Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro.FOOD AND CHEMICAL TOXICOLOGY,60,497-505.
MLA Kong, Dan,et al."Individual and combined developmental toxicity assessment of bisphenol A and genistein using the embryonic stem cell test in vitro".FOOD AND CHEMICAL TOXICOLOGY 60(2013):497-505.
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