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T-type calcium channel gene alpha (1G) is not associated with childhood absence epilepsy in the Chinese Han population
Chen, YC; Lu, JJ; Zhang, YH; Pan, H; Wu, HS; Xu, KM; Liu, XY; Jiang, YW; Bao, XH; Zhou, J; Liu, W; Shi, GB; Shen, Y; Wu, XR
关键词childhood absence epilepsy mutation single nucleotide polymorphisms susceptibility gene Chinese T-type Ca2+ channel alpha (1G)
刊名NEUROSCIENCE LETTERS
2003-04-24
DOI10.1016/S0304-3940(02)00124-1
341期:1页:29-32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]THALAMIC NEURONS ; WAVE DISCHARGES ; LOW-THRESHOLD ; RAT ; ETHOSUXIMIDE ; CELLS ; SPIKE ; MODEL ; DRUG
英文摘要

We investigated whether the T-type calcium channel gene alpha (IG) is associated with childhood absence epilepsy (CAE), a form of idiopathic generalized epilepsy. We carried out direct sequencing of exons 1-37 and the exon-intron boundaries of the alpha (1G) gene in 48 Han Chinese patients with CAE and 48 normal controls. We found no mutation in the exons of alpha (I G). However, we did identify six single nucleotide polymorphisms (SNPs). Using two of these as markers, we carried out a case-control study in 192 patients with CAE and 192 normal controls. The allele and genotype distributions of all the SNPs studied were not significantly different between cases and control groups, thus the alpha (1G) gene is not an important susceptibility gene for CAE, at least in the Chinese population. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000182202100008
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62668
专题北京大学第一临床医学院_儿科
作者单位1.Natl Ctr Human Genome Res, Beijing 100176, Peoples R China
2.Beijing Childrens Hosp, Beijing 100045, Peoples R China
3.Capital Inst Pediat, Beijing 100020, Peoples R China
4.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
5.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
推荐引用方式
GB/T 7714
Chen, YC,Lu, JJ,Zhang, YH,et al. T-type calcium channel gene alpha (1G) is not associated with childhood absence epilepsy in the Chinese Han population[J]. NEUROSCIENCE LETTERS,2003,341(1):29-32.
APA Chen, YC.,Lu, JJ.,Zhang, YH.,Pan, H.,Wu, HS.,...&Wu, XR.(2003).T-type calcium channel gene alpha (1G) is not associated with childhood absence epilepsy in the Chinese Han population.NEUROSCIENCE LETTERS,341(1),29-32.
MLA Chen, YC,et al."T-type calcium channel gene alpha (1G) is not associated with childhood absence epilepsy in the Chinese Han population".NEUROSCIENCE LETTERS 341.1(2003):29-32.
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