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学科主题药学
Development of interventional whole body hyperthermia system: Part II: In vivo animal experimental evaluation
Xiang, Shi-Hai1; Chen, Bo-Wei1; He, Xi-Hui2; Sun, Hong3; Zhou, Yi-Xin1; Deng, Zhong-Shan1; Yang, Yang1; Rao, Wei1; Yan, Jing-Fu1; Yan, Xiao-Ming1; Liu, Jing1
关键词Interventional whole body hyperthermia IWBH device Animal experiment Heating efficiency Toxicity
刊名FORSCHUNG IM INGENIEURWESEN-ENGINEERING RESEARCH
2009-09-01
DOI10.1007/s10010-008-0087-7
73期:3页:139-146
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Multidisciplinary ; Engineering, Mechanical
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Engineering
关键词[WOS]CARCINOMA ; THERAPY ; DEVICE ; BLOOD
英文摘要

Our previous works have confirmed the feasibility of interventionl whole body hyperthermia (IWBH) via a series of physical simulation and theoretical analysis. In this paper, experiments were performed on large mammal (canine) in order to further verify in vivo the interventional whole body hyperthermia with the first generation IWBH device developed by our research team. Whole body fever (rectum temperature from 38.6-40.8 A degrees C) was induced and no significant toxicity correlated with IWBH was found. The changes in cardiovascular, respiratory, haemodynamic indices as well as temperature response of the experimental canine were monitored with a physiological monitoring system. The first hand experimental information about IWBH with animal model was obtained. The experimental result demonstrated that IWBH method is relatively safe for animal and is effective in raising body core temperature. Finally, the issues emerging in the experiment and the way to solve them were discussed.

语种英语
所属项目编号50776097
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000269309100003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62675
Collection北京大学药学院
作者单位1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Ctr Hlth, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China
Recommended Citation
GB/T 7714
Xiang, Shi-Hai,Chen, Bo-Wei,He, Xi-Hui,et al. Development of interventional whole body hyperthermia system: Part II: In vivo animal experimental evaluation[J]. FORSCHUNG IM INGENIEURWESEN-ENGINEERING RESEARCH,2009,73(3):139-146.
APA Xiang, Shi-Hai.,Chen, Bo-Wei.,He, Xi-Hui.,Sun, Hong.,Zhou, Yi-Xin.,...&Liu, Jing.(2009).Development of interventional whole body hyperthermia system: Part II: In vivo animal experimental evaluation.FORSCHUNG IM INGENIEURWESEN-ENGINEERING RESEARCH,73(3),139-146.
MLA Xiang, Shi-Hai,et al."Development of interventional whole body hyperthermia system: Part II: In vivo animal experimental evaluation".FORSCHUNG IM INGENIEURWESEN-ENGINEERING RESEARCH 73.3(2009):139-146.
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