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学科主题: 药学
题名:
Development of interventional whole body hyperthermia system: Part II: In vivo animal experimental evaluation
作者: Xiang, Shi-Hai1; Chen, Bo-Wei1; He, Xi-Hui2; Sun, Hong3; Zhou, Yi-Xin1; Deng, Zhong-Shan1; Yang, Yang1; Rao, Wei1; Yan, Jing-Fu1; Yan, Xiao-Ming1; Liu, Jing1
关键词: Interventional whole body hyperthermia ; IWBH device ; Animal experiment ; Heating efficiency ; Toxicity
刊名: FORSCHUNG IM INGENIEURWESEN-ENGINEERING RESEARCH
发表日期: 2009-09-01
DOI: 10.1007/s10010-008-0087-7
卷: 73, 期:3, 页:139-146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Multidisciplinary ; Engineering, Mechanical
研究领域[WOS]: Engineering
关键词[WOS]: CARCINOMA ; THERAPY ; DEVICE ; BLOOD
英文摘要:

Our previous works have confirmed the feasibility of interventionl whole body hyperthermia (IWBH) via a series of physical simulation and theoretical analysis. In this paper, experiments were performed on large mammal (canine) in order to further verify in vivo the interventional whole body hyperthermia with the first generation IWBH device developed by our research team. Whole body fever (rectum temperature from 38.6-40.8 A degrees C) was induced and no significant toxicity correlated with IWBH was found. The changes in cardiovascular, respiratory, haemodynamic indices as well as temperature response of the experimental canine were monitored with a physiological monitoring system. The first hand experimental information about IWBH with animal model was obtained. The experimental result demonstrated that IWBH method is relatively safe for animal and is effective in raising body core temperature. Finally, the issues emerging in the experiment and the way to solve them were discussed.

语种: 英语
所属项目编号: 50776097
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000269309100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62675
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Ctr Hlth, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China

Recommended Citation:
Xiang, Shi-Hai,Chen, Bo-Wei,He, Xi-Hui,et al. Development of interventional whole body hyperthermia system: Part II: In vivo animal experimental evaluation[J]. FORSCHUNG IM INGENIEURWESEN-ENGINEERING RESEARCH,2009,73(3):139-146.
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