|A retrospective monocenter review of simultaneous pancreas-kidney transplantation with bladder drainage in China|
|Bi Hai; Hou Xiao-fei; Ma Lu-lin; Luo Kang-ping; Wang Guo-liang; Zhao Lei; Liu Ya-li|
|关键词||pancreas transplantation kidney transplantation survival rate postoperative complications|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||SINGLE-CENTER ; ENTERIC DRAINAGE ; FOLLOW-UP ; OUTCOMES ; COMPLICATIONS|
Background Simultaneous pancreas-kidney transplantation (SPKT) frees the diabetic patient with end-stage nephropathy from dialysis and daily insulin injections. Herein, we review consecutive cases of SPKT with bladder drainage performed at our institution over an 8-year period.
Methods The study population included 21 patients (16 males and 5 females) who underwent SPKT between September 2001 and September 2009. Seven patients had type-1 diabetes and 14 had type-2 diabetes. Nineteen patients were on dialysis at the time of transplantation. Donation after cardiac death donors were selected for SPKT. The mean human leukocyte antigen match was 2 (range 0-4). SPKT was always performed using bladder drainage and vascular anastomoses to the systemic circulation. Immunosuppressive treatment consisted of anti-lymphocyte globulin induction followed by tacrolimus, mycophenolate mofetil, and prednisone.
Results The mean hospital stay was 45.43 days. After a mean follow-up of 39.4 months, survival rates for patient, kidney, and pancreas were 76.2%, 76.2%, and 66.7% at 1 year; 76.2%, 59.3%, and 55.6% at 5 years; and 57.1%, 39.5%, and 41.7% at 8 years, respectively. Major complications included anastomotic leaks, reflux pancreatitis, and rejection. Six patients died from septic shock (n=3), duodenal stump leak (1), cardiac arrest (1), or renal failure (1). Eight kidney grafts were lost due to acute rejection (n=2), chronic rejection (3), and death with a functioning graft (3). Pancreatic graft failure (9) was caused by thrombosis (n=1), rejection (2), duodenal stump leak (1), and death with a functioning graft (5).
Conclusions SPKT is a valid therapeutic option for uremic diabetics although few hospitals in China can undertake SPKT. Chin Med J 2011;124(2):205-209
|作者单位||Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China|
|Bi Hai,Hou Xiao-fei,Ma Lu-lin,et al. A retrospective monocenter review of simultaneous pancreas-kidney transplantation with bladder drainage in China[J]. CHINESE MEDICAL JOURNAL,2011,124(2):205-209.|
|APA||Bi Hai.,Hou Xiao-fei.,Ma Lu-lin.,Luo Kang-ping.,Wang Guo-liang.,...&Liu Ya-li.(2011).A retrospective monocenter review of simultaneous pancreas-kidney transplantation with bladder drainage in China.CHINESE MEDICAL JOURNAL,124(2),205-209.|
|MLA||Bi Hai,et al."A retrospective monocenter review of simultaneous pancreas-kidney transplantation with bladder drainage in China".CHINESE MEDICAL JOURNAL 124.2(2011):205-209.|