IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice
Wang, Jinyu; Xian, Xunde; Huang, Wei; Chen, Li; Wu, Liling; Zhu, Yi; Fan, Jianglin; Ross, Colin; Hayden, Michael R.; Liu, George
关键词lipoprotein lipase atherosclerosis vascular cell adhesion molecule-1 mice gene transfer
刊名ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
2007
DOI10.1161/01.ATV.0000249683.80414.d9
27期:1页:197-203
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]SMOOTH-MUSCLE-CELLS ; DENSITY-LIPOPROTEIN RECEPTOR ; LPLS447X BENEFICIAL MUTATION ; GENE-TRANSFER ; ATHEROSCLEROTIC LESIONS ; LIPASE ; LIPOLYSIS ; PATIENT ; MOUSE ; WALL
英文摘要

Objective-Overexpression of lipoprotein lipase (LPL) in deendothelialized artery led to profound localized lipid deposition. In this study the role of LPL in atherogenesis in endothelial-intact carotid arteries was assessed in genetically hyperlipidemic LPL- and ApoE-deficient mice.

Methods and Results-Human wild-type LPL (hLPLwt), catalytically inactive LPL (hLPL194), or control alkaline phosphatase (hAP) were expressed in endothelial-intact carotid arteries via adenoviral vectors. Compared with Ad-hAP, lipid deposition in the arterial wall increased 10.0- and 5.1-fold for Ad-hLPLwt and Ad-hLPL194 in LPL- deficient mice, and 10.6- and 6.2-fold in ApoE-deficient mice, respectively. Vascular cell adhesion molecule-1 (VCAM-1) was upregulated in Ad-hLPLwt and Ad-hLPL194 transferred arteries.

Conclusions-Endothelial cell associated LPL, either active or inactive, in the arterial wall is a strong proatherosclerotic factor in both LPL- and ApoE-deficient mice.

语种英语
WOS记录号WOS:000243572000031
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62682
专题北京大学基础医学院_心血管所
作者单位1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
4.Univ Tsukuba, Cardiovasc Dis Lab, Dept Pathol, Inst Basic Med Sci, Tsukuba, Ibaraki 305, Japan
5.Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada
6.Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 1M9, Canada
推荐引用方式
GB/T 7714
Wang, Jinyu,Xian, Xunde,Huang, Wei,et al. Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2007,27(1):197-203.
APA Wang, Jinyu.,Xian, Xunde.,Huang, Wei.,Chen, Li.,Wu, Liling.,...&Liu, George.(2007).Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,27(1),197-203.
MLA Wang, Jinyu,et al."Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 27.1(2007):197-203.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
197.full.pdf(1226KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Jinyu]的文章
[Xian, Xunde]的文章
[Huang, Wei]的文章
百度学术
百度学术中相似的文章
[Wang, Jinyu]的文章
[Xian, Xunde]的文章
[Huang, Wei]的文章
必应学术
必应学术中相似的文章
[Wang, Jinyu]的文章
[Xian, Xunde]的文章
[Huang, Wei]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 197.full.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。