IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice
Wang, Jinyu; Xian, Xunde; Huang, Wei; Chen, Li; Wu, Liling; Zhu, Yi; Fan, Jianglin; Ross, Colin; Hayden, Michael R.; Liu, George
关键词lipoprotein lipase atherosclerosis vascular cell adhesion molecule-1 mice gene transfer
刊名ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
2007
DOI10.1161/01.ATV.0000249683.80414.d9
27期:1页:197-203
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]SMOOTH-MUSCLE-CELLS ; DENSITY-LIPOPROTEIN RECEPTOR ; LPLS447X BENEFICIAL MUTATION ; GENE-TRANSFER ; ATHEROSCLEROTIC LESIONS ; LIPASE ; LIPOLYSIS ; PATIENT ; MOUSE ; WALL
英文摘要

Objective-Overexpression of lipoprotein lipase (LPL) in deendothelialized artery led to profound localized lipid deposition. In this study the role of LPL in atherogenesis in endothelial-intact carotid arteries was assessed in genetically hyperlipidemic LPL- and ApoE-deficient mice.

Methods and Results-Human wild-type LPL (hLPLwt), catalytically inactive LPL (hLPL194), or control alkaline phosphatase (hAP) were expressed in endothelial-intact carotid arteries via adenoviral vectors. Compared with Ad-hAP, lipid deposition in the arterial wall increased 10.0- and 5.1-fold for Ad-hLPLwt and Ad-hLPL194 in LPL- deficient mice, and 10.6- and 6.2-fold in ApoE-deficient mice, respectively. Vascular cell adhesion molecule-1 (VCAM-1) was upregulated in Ad-hLPLwt and Ad-hLPL194 transferred arteries.

Conclusions-Endothelial cell associated LPL, either active or inactive, in the arterial wall is a strong proatherosclerotic factor in both LPL- and ApoE-deficient mice.

语种英语
WOS记录号WOS:000243572000031
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62682
Collection北京大学基础医学院_心血管所
作者单位1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
4.Univ Tsukuba, Cardiovasc Dis Lab, Dept Pathol, Inst Basic Med Sci, Tsukuba, Ibaraki 305, Japan
5.Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada
6.Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 1M9, Canada
Recommended Citation
GB/T 7714
Wang, Jinyu,Xian, Xunde,Huang, Wei,et al. Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2007,27(1):197-203.
APA Wang, Jinyu.,Xian, Xunde.,Huang, Wei.,Chen, Li.,Wu, Liling.,...&Liu, George.(2007).Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,27(1),197-203.
MLA Wang, Jinyu,et al."Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 27.1(2007):197-203.
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