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学科主题: 基础医学
题名:
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice
作者: Wang, Jinyu; Xian, Xunde; Huang, Wei; Chen, Li; Wu, Liling; Zhu, Yi; Fan, Jianglin; Ross, Colin; Hayden, Michael R.; Liu, George
关键词: lipoprotein lipase ; atherosclerosis ; vascular cell adhesion molecule-1 ; mice ; gene transfer
刊名: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
发表日期: 2007
DOI: 10.1161/01.ATV.0000249683.80414.d9
卷: 27, 期:1, 页:197-203
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; DENSITY-LIPOPROTEIN RECEPTOR ; LPLS447X BENEFICIAL MUTATION ; GENE-TRANSFER ; ATHEROSCLEROTIC LESIONS ; LIPASE ; LIPOLYSIS ; PATIENT ; MOUSE ; WALL
英文摘要:

Objective-Overexpression of lipoprotein lipase (LPL) in deendothelialized artery led to profound localized lipid deposition. In this study the role of LPL in atherogenesis in endothelial-intact carotid arteries was assessed in genetically hyperlipidemic LPL- and ApoE-deficient mice.

Methods and Results-Human wild-type LPL (hLPLwt), catalytically inactive LPL (hLPL194), or control alkaline phosphatase (hAP) were expressed in endothelial-intact carotid arteries via adenoviral vectors. Compared with Ad-hAP, lipid deposition in the arterial wall increased 10.0- and 5.1-fold for Ad-hLPLwt and Ad-hLPL194 in LPL- deficient mice, and 10.6- and 6.2-fold in ApoE-deficient mice, respectively. Vascular cell adhesion molecule-1 (VCAM-1) was upregulated in Ad-hLPLwt and Ad-hLPL194 transferred arteries.

Conclusions-Endothelial cell associated LPL, either active or inactive, in the arterial wall is a strong proatherosclerotic factor in both LPL- and ApoE-deficient mice.

语种: 英语
WOS记录号: WOS:000243572000031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62682
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
4.Univ Tsukuba, Cardiovasc Dis Lab, Dept Pathol, Inst Basic Med Sci, Tsukuba, Ibaraki 305, Japan
5.Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada
6.Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 1M9, Canada

Recommended Citation:
Wang, Jinyu,Xian, Xunde,Huang, Wei,et al. Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2007,27(1):197-203.
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