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学科主题: 临床医学
题名:
Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis
作者: Fan, Shangrong1,3; Liu, Xiaopingliu2; Liang, Yiheng1
关键词: Vulvovaginal candidiasis ; Miconazole ; Fluconazole
刊名: GYNECOLOGIC AND OBSTETRIC INVESTIGATION
发表日期: 2015
DOI: 10.1159/000371759
卷: 80, 期:2, 页:113-118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: CANDIDOSIS ; SINGLE ; OVULE ; VAGINITIS ; SUSCEPTIBILITY ; MANAGEMENT ; BLIND
英文摘要:

Aims: Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). Methods: In this prospective, randomized case control study, 577 cases of consecutive patients with SVVC were studied at the Gynecological Clinic of Peking University Shenzhen Hospital from January 1, 2009 through December 31, 2010. Patients with SVVC were treated with two doses of miconazole nitrate vaginal suppository 1,200 mg or two doses of fluconazole 150 mg. The patients were followed up for 7-14 and 30-35 days following the second dose of therapy. Results: The mycological cure rates of the patients on days 7-14 of follow-up were 75.9% (220/290) and 84.0% (241/287) in the miconazole and fluconazole groups, respectively (p < 0.05). The mycological cure rates of the patients at the second follow-up were 64.8% (188/290) and 69.7% (200/287), respectively, in the two groups (p > 0.05). Conclusion: The study demonstrated that two doses of miconazole nitrate vaginal suppository 1,200 mg were as effective as two doses of an oral fluconazole 150 mg regimen in the treatment of patients with SVVC. (C) 2015 S. Karger AG, Basel

语种: 英语
所属项目编号: 200702108 ; 200703031 ; 20120320020 ; JCYJ 20140415162338813
项目资助者: Shenzhen Science and Technology Grant
WOS记录号: WOS:000360450100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62684
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shenzhen Key Lab Gynecol Diagnost Technol Res, Shenzhen, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China

Recommended Citation:
Fan, Shangrong,Liu, Xiaopingliu,Liang, Yiheng. Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis[J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION,2015,80(2):113-118.
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