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Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis
Fan, Shangrong1,3; Liu, Xiaopingliu2; Liang, Yiheng1
关键词Vulvovaginal candidiasis Miconazole Fluconazole
刊名GYNECOLOGIC AND OBSTETRIC INVESTIGATION
2015
DOI10.1159/000371759
80期:2页:113-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]CANDIDOSIS ; SINGLE ; OVULE ; VAGINITIS ; SUSCEPTIBILITY ; MANAGEMENT ; BLIND
英文摘要

Aims: Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). Methods: In this prospective, randomized case control study, 577 cases of consecutive patients with SVVC were studied at the Gynecological Clinic of Peking University Shenzhen Hospital from January 1, 2009 through December 31, 2010. Patients with SVVC were treated with two doses of miconazole nitrate vaginal suppository 1,200 mg or two doses of fluconazole 150 mg. The patients were followed up for 7-14 and 30-35 days following the second dose of therapy. Results: The mycological cure rates of the patients on days 7-14 of follow-up were 75.9% (220/290) and 84.0% (241/287) in the miconazole and fluconazole groups, respectively (p < 0.05). The mycological cure rates of the patients at the second follow-up were 64.8% (188/290) and 69.7% (200/287), respectively, in the two groups (p > 0.05). Conclusion: The study demonstrated that two doses of miconazole nitrate vaginal suppository 1,200 mg were as effective as two doses of an oral fluconazole 150 mg regimen in the treatment of patients with SVVC. (C) 2015 S. Karger AG, Basel

语种英语
WOS记录号WOS:000360450100008
项目编号200702108 ; 200703031 ; 20120320020 ; JCYJ 20140415162338813
资助机构Shenzhen Science and Technology Grant
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62684
专题北京大学深圳医院
作者单位1.Shenzhen Key Lab Gynecol Diagnost Technol Res, Shenzhen, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
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GB/T 7714
Fan, Shangrong,Liu, Xiaopingliu,Liang, Yiheng. Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis[J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION,2015,80(2):113-118.
APA Fan, Shangrong,Liu, Xiaopingliu,&Liang, Yiheng.(2015).Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis.GYNECOLOGIC AND OBSTETRIC INVESTIGATION,80(2),113-118.
MLA Fan, Shangrong,et al."Miconazole Nitrate Vaginal Suppository 1,200 mg versus Oral Fluconazole 150 mg in Treating Severe Vulvovaginal Candidiasis".GYNECOLOGIC AND OBSTETRIC INVESTIGATION 80.2(2015):113-118.
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