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Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment
Gupta, Saurabh1; Iudicello, Jennifer E.1; Shi, Chuan3; Letendre, Scott1; Knight, Adam1; Li, Jianhua5; Riggs, Patricia K.1; Franklin, Donald R., Jr.1; Duarte, Nichole1; Jin, Hua1,2; Atkinson, J. Hampton1,2; Yu, Xin3; Wu, Zunyou4; Grant, Igor1; Heaton, Robert K.1; HNRC China Collaboration Grp1
关键词HCV Neurocognitive impairment China Injection drugs
刊名DRUG AND ALCOHOL DEPENDENCE
2014-04-01
DOI10.1016/j.drugalcdep.2013.12.021
137页:29-35
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Substance Abuse ; Psychiatry
研究领域[WOS]Substance Abuse ; Psychiatry
关键词[WOS]HEPATITIS-C VIRUS ; SIMPLE NONINVASIVE INDEX ; FORMER PLASMA DONORS ; SUB-SAHARAN AFRICA ; NEUROPSYCHOLOGICAL IMPAIRMENT ; MAINTENANCE PATIENTS ; COGNITIVE IMPAIRMENT ; SIGNIFICANT FIBROSIS ; HIV-INFECTION ; MENTAL-HEALTH
英文摘要

Background: Prior research has demonstrated neuropsychological (NP) impairment in persons with histories of injection drug use (IDU), hepatitis C virus (HCV) infection, and methadone maintenance treatment (MMT), individually, but little is known about the NP effects of these three risk factors in combination. This issue is particularly important in China, which is addressing its highly HCV-comorbid IOU epidemic with widespread government sponsored MMT, especially in light of recent evidence suggesting that methadone may be neuroprotective in some circumstances.

Methods: We administered a comprehensive NP test battery to 195 Chinese heroin IDU individuals taking MMT (IDU+ group), the majority of whom were also HCV+ (87%; n = 169), and compared their NP performance to that of 198 demographically comparable, non-IDU Chinese controls (IOU group). All participants in both groups tested negative for HIV infection, which is also a common comorbidity in the Chinese IDU population.

Results: The IDU+ group did not have an increased rate of global NP impairment, or perform significantly worse on any individual NP test measure. Within the IDU+ group, liver disease characteristics and reported details of heroin use were not significantly associated with NP performance.

Conclusion: Failure to detect NP impairment in IDU+ subjects with or without HCV infection was surprising, particularly considering the previously demonstrated sensitivity of our NP battery to neurocognitive disorders associated with HIV infection in China. One possible explanation, which should be explored in future research, is the potential neuroprotective effect of methadone in the context of HCV infection and/or heroin withdrawal. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000334134200004
项目编号R01MH073433 ; P30MH062512 ; T32DA031098 ; L30DA034362
资助机构National Institutes of Health, Bethesda, MD
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62690
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Univ Calif San Diego, HIV Neurobehav Res Program, San Diego, CA 92103 USA
2.VA San Diego Healthcare Syst, San Diego, CA USA
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.China Ctr Dis Control China CDC, Beijing, Peoples R China
5.China Yunnan Inst Drug Abuse, Kunming, Peoples R China
推荐引用方式
GB/T 7714
Gupta, Saurabh,Iudicello, Jennifer E.,Shi, Chuan,et al. Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment[J]. DRUG AND ALCOHOL DEPENDENCE,2014,137:29-35.
APA Gupta, Saurabh.,Iudicello, Jennifer E..,Shi, Chuan.,Letendre, Scott.,Knight, Adam.,...&HNRC China Collaboration Grp.(2014).Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment.DRUG AND ALCOHOL DEPENDENCE,137,29-35.
MLA Gupta, Saurabh,et al."Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment".DRUG AND ALCOHOL DEPENDENCE 137(2014):29-35.
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