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学科主题: 精神卫生
题名:
Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment
作者: Gupta, Saurabh1; Iudicello, Jennifer E.1; Shi, Chuan3; Letendre, Scott1; Knight, Adam1; Li, Jianhua5; Riggs, Patricia K.1; Franklin, Donald R., Jr.1; Duarte, Nichole1; Jin, Hua1,2; Atkinson, J. Hampton1,2; Yu, Xin3; Wu, Zunyou4; Grant, Igor1; Heaton, Robert K.1; HNRC China Collaboration Grp1
关键词: HCV ; Neurocognitive impairment ; China ; Injection drugs
刊名: DRUG AND ALCOHOL DEPENDENCE
发表日期: 2014-04-01
DOI: 10.1016/j.drugalcdep.2013.12.021
卷: 137, 页:29-35
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Substance Abuse ; Psychiatry
研究领域[WOS]: Substance Abuse ; Psychiatry
关键词[WOS]: HEPATITIS-C VIRUS ; SIMPLE NONINVASIVE INDEX ; FORMER PLASMA DONORS ; SUB-SAHARAN AFRICA ; NEUROPSYCHOLOGICAL IMPAIRMENT ; MAINTENANCE PATIENTS ; COGNITIVE IMPAIRMENT ; SIGNIFICANT FIBROSIS ; HIV-INFECTION ; MENTAL-HEALTH
英文摘要:

Background: Prior research has demonstrated neuropsychological (NP) impairment in persons with histories of injection drug use (IDU), hepatitis C virus (HCV) infection, and methadone maintenance treatment (MMT), individually, but little is known about the NP effects of these three risk factors in combination. This issue is particularly important in China, which is addressing its highly HCV-comorbid IOU epidemic with widespread government sponsored MMT, especially in light of recent evidence suggesting that methadone may be neuroprotective in some circumstances.

Methods: We administered a comprehensive NP test battery to 195 Chinese heroin IDU individuals taking MMT (IDU+ group), the majority of whom were also HCV+ (87%; n = 169), and compared their NP performance to that of 198 demographically comparable, non-IDU Chinese controls (IOU group). All participants in both groups tested negative for HIV infection, which is also a common comorbidity in the Chinese IDU population.

Results: The IDU+ group did not have an increased rate of global NP impairment, or perform significantly worse on any individual NP test measure. Within the IDU+ group, liver disease characteristics and reported details of heroin use were not significantly associated with NP performance.

Conclusion: Failure to detect NP impairment in IDU+ subjects with or without HCV infection was surprising, particularly considering the previously demonstrated sensitivity of our NP battery to neurocognitive disorders associated with HIV infection in China. One possible explanation, which should be explored in future research, is the potential neuroprotective effect of methadone in the context of HCV infection and/or heroin withdrawal. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: R01MH073433 ; P30MH062512 ; T32DA031098 ; L30DA034362
项目资助者: National Institutes of Health, Bethesda, MD
WOS记录号: WOS:000334134200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62690
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Calif San Diego, HIV Neurobehav Res Program, San Diego, CA 92103 USA
2.VA San Diego Healthcare Syst, San Diego, CA USA
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.China Ctr Dis Control China CDC, Beijing, Peoples R China
5.China Yunnan Inst Drug Abuse, Kunming, Peoples R China

Recommended Citation:
Gupta, Saurabh,Iudicello, Jennifer E.,Shi, Chuan,et al. Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment[J]. DRUG AND ALCOHOL DEPENDENCE,2014,137:29-35.
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