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学科主题: 药学
题名:
Regioselective modification of amino groups in aminoglycosides based on cyclic carbamate formation
作者: Chen, Guihui; Pan Pan; Yao, Yun; Chen, Ying; Meng, Xiangbao; Li, Zhongjun
关键词: cyclic carbamate ; regioselectivity ; amino group modification
刊名: TETRAHEDRON
发表日期: 2008-09-15
DOI: 10.1016/j.tet.2008.07.022
卷: 64, 期:38, 页:9078-9087
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: STAUDINGER REACTION ; N-1 MODIFICATION ; ANTIBIOTICS ; RNA ; RESISTANCE ; RIBOSTAMYCIN ; KANAMYCIN ; AMIKACIN ; ENZYMES ; DESIGN
英文摘要:

Conditions for regioselective introduction of cyclic carbamate into per-N-Cbz neamine and per-N-Cbz kanamycin A have been found. The position and number of cyclic Carbamate formed in these two aminoglycosides was controllable. On the base of selective cyclic carbamate formation, regioselective modification on N-1, N-6′ or both amino groups in neat-nine, and on N-6′, N-3 ′′ or both amino groups in kanamycin A was achieved by ring-opening reaction with amines. A new neamine dimer linked at the N-1 was also synthesized with this method. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2004CB518904
项目资助者: National Basic Research Program
WOS记录号: WOS:000259045100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62691
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Chen, Guihui,Pan Pan,Yao, Yun,et al. Regioselective modification of amino groups in aminoglycosides based on cyclic carbamate formation[J]. TETRAHEDRON,2008,64(38):9078-9087.
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